Vol 8, No 3 (2011)

In this review there are modern data concerning the prevalence of allergic diseases among athletes of the highest achievements, their influence on health and level of athletic achievements.

Background. To investigate the influence of mometasone furoate 0,1% cream on cytokine gene expression in the skin and peripheral blood of atopic dermatitis (AD) patients comparing with control. Material and methods. 40 AD patients were included in the study and divided into 2 groups. group 1 patients were given continuous course of mometasone furoate 0,1% cream treatment for 14 days. group 2 patients were given indifferent emollient elobase cream for 14 days. Clinical efficacy of the treatment was assessed on the following features: SCORAD index, Investigators global Assessment (IgA) score and subjective assessment of itch and dryness of the skin according to skin area to be studied. Skin samples and peripheral blood of atopic dermatitis were used as material for immunological study. Interleukin (IL)1B, IL2, IL2r, IL4, IL5, IL6, IL7, IL8, IL10, IL 12A, IL12B, IL15 (total), IL15 , IL17A, IL18, IL23, IL28, IL29, Interferon (IFN)-ƒ, Tumor necrosis factor (TNF), Transforming growth factor beta 1 (TGFB1), forkhead box P3 (FOXP3) gene expression were defined in the skin and peripheral blood of AD patients by realtime reverse transcription polymerase chain reaction (RT-pCR). Results. positive clinical effect was found with all AD patients on the mometasone furoate 0,1% cream therapy background for 14 days and also dryness, rushes and skin itch decreased. Stаtistical significant decrease of proinflammatory cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN-ƒ gene expression was marked. They are the markers of chronic inflammation and Th1 immune response. Studying peripheral blood after mometasone furoate 0,1% cream treatment increase of TGFB1, FOXP3 gene expression level was found. no significant changes of cytokine gene expression in AD patients, who got elobase cream were found. Conclusion. Antiinflammatory activity of mometasone furoate 0,1% cream was shown by its influence on proinflammatory cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN-ƒ gene expression in the skin and mechanisms of immune response in moderate and severe AD patients.

Background. Staphylococus aureus (S. aureus) colonization is revealed in 87-90% patients with atopic dermatitis (aD). S. aureus antibiotic susceptibility differs within time. the study is aimed to investigate the dynamics of S.aureus susceptibility to antibiotics and time limitation of this process in children with aD. Methods. S. aureus susceptibility to 19 antibiotics was analyzed with 72 resistance patterns (31 initial and 41 repeated in 0,5-30 months) of 203 performed in 647 children with aD tested in 2007-2009 years. results. in a three year period (2007-2009) a negative correlation of S. aureus antibiotic susceptible strains prevalence versus months since initial pattern was revealed (R=−0,29 p<0,01; г=−0,29, p<0,003; ф=−0,23 p<0,003). prevalence of antibiotic susceptible strains prevailed initially more than two times over resistant one has become not reliable in 12 months. conclusion. a child with aD is needed to be set and clear up with anti-inflammatory and antibacterial therapy in a 12 months period past hospital check-up. the decrease of S. aureus antibiotic susceptible strains within this period could probably reduce the effect of the following antibacterial therapy.

Background. Study of the аssociations of susceptibility genes to the development of atopic diseases in children. Materials and methods. All 325 examined children reside on the territory of the European part of Russia who by according to surveys, Russian by nationality. Analysis of polymorphism in genes of receptors ADRB2, GRL, ALOX5, genes of biotransformation - CYP1A1, CYP2C9, CYP2C19, GSTT1, GSTM1, NAT2 as well as the variants of the genes MTHFR and TNFA was performed in patients suffering from atopic disease and in healthy individuals. Using Multifactor Dimentionality Reduction method (MDR) it was defined the most significant model of genegene interaction for the development of atopic disease Results. Association of the development of atopic diseases with polymorphic variants of the genes: ALOX5 (VNTR) GRL (1220A > G) TNFA (-308G > A) CYP1A1 (6235T > C) and GSTM1 was identified in surveyed children. The highrisk alleles and genotypes of developing atopic diseases in pediatric patients were determined. Using Multifactor Dimentionality Reduction method (MDR) it was defined the most significant model of gene-gene interaction for the development of atopic disease, including ADRB2 (79 C >G), (46A > G), CYP2C19 (G681A) was defined. Conclusion. There were identified polymorphic variants of genes and important gene-gene interactions associated with development of atopic diseases in children.

traditionally, bronchial asthma (Ba) was considered as a disease of large and medium bronchi, but recently obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract. several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal place of airflow obstruction in patients with asthma. there are currently actively being developed devices for improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.

data and tables after classification, a spectrum of food allergens, food additives and their role in development of a food allergy and food intolerance are presented. recommendations for the practical doctor on features of a diet are presented