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REMOTE RESULTS OF SUBLINGUAL ALLERGENSPECIFICIMMUNOTHERAPY AT POLLINOSIS PATIENTS - FIVE YEARS'RESEARCH
- Authors: Manzhos M.V.1, Fedenko ES1, Myagkova MA1, Keropyan GA1, Shkadov SA1, Peretrukhin AI1, Manzhos MV2, Fedenko ES3, Myagkova MA4, Keropyan GA3, Shkadov SA2, Peretruhin AI2
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Affiliations:
- City clinical hospital № 4
- Institute of immunology
- Institute physiologically active substances of the Russian Academy of Science
- Issue: Vol 8, No 3 (2011)
- Pages: 31-36
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.09.2011
- URL: https://rusalljournal.ru/raj/article/view/788
- DOI: https://doi.org/10.36691/RJA788
- ID: 788
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Abstract
immunotherapy (SLiT) at pollinosis patients.
Methods. 25 patients at the age from 19 till 50 years old with an allergic rhinitis and asthma (35%) sensitized to
artemisia were under the supervision. SLiT was administered in the period since September 2003 till May 2006
with pollen allergen («Sevapharma», Czech Republik). The average total dose of the allergen per one patient
at the end of the third year was 189999 PNU. Clinical efficiency was estimated annually and in 30 months after
discontinuation of SLiT. Frequency and intensity of symptoms during the pollen season, requirement for medicines,
FEV1 parameters and results of prick tests were considered.
Results. good and excellent results after three courses of immunotherapy demonstrated 23 patients (92%), satisfactory
- 2 patients (8%). The results were remained at 22 patients (88%) within the next 30 months. at 3 patients
(12%) increase of rhinoconjunctivitis symptoms was noted, and 3 (12%) showed expansion of a sensibilisation
spectrum. Further increase of intensity and frequency of asthma symptoms, decrease in indicators FEV1 was not
registered.
Conclusion. SLiT is a highly effective method of treatment for patients with seasonal rhinitis and leads to the
clinical results remaining more than 2 years at the majority of patients.
About the authors
Marina Valentinovna Manzhos
Email: mmv_kinel@mail.ru
E S Fedenko
M A Myagkova
G A Keropyan
S A Shkadov
A I Peretrukhin
M V Manzhos
City clinical hospital № 4City clinical hospital № 4
E S Fedenko
Institute of immunologyInstitute of immunology
M A Myagkova
Institute physiologically active substances of the Russian Academy of ScienceInstitute physiologically active substances of the Russian Academy of Science
G A Keropyan
Institute of immunologyInstitute of immunology
S A Shkadov
City clinical hospital № 4City clinical hospital № 4
A I Peretruhin
City clinical hospital № 4City clinical hospital № 4
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