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Vol 8, No 3 (2011)

Articles
ALLERGY AND SPORTS
Uyba V.V., Khaitov R.M., Il'ina N.I., Luss L.V., Martynov A.I., Ujba V.V., Khaitov R.M., Ilina N.I., luss l.V., Martynov A.I.
Abstract
In this review there are modern data concerning the prevalence of allergic diseases among athletes of the highest achievements, their influence on health and level of athletic achievements.
Russian Journal of Allergy. 2011;8(3):3-13
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THE GENETIC AND CLINICAL ASPECTS OF HAE, NEWPOSSIBILITIES OF THE DISEASE EXACERBATIONS TREATMENT
Latysheva T.V., Polyakov A.V., Dmitrieva A.V., Medunitsyna E.N., Latysheva T.V., Polyakov A.V., Dmitrieva A.V., Medunitsyna E.N.
Abstract
Continued study of genetic and clinical aspects of hereditary angioedema (HAE) types I and II, which belongs to the group of primary (genetically determined) immunodeficiencies and is connected with the qualitative or quantitative genetically determined defect of C1 Inhibitor. HAE is an «orphan» disease and requires the establishment of a Government strategy for patients with this rare diagnosis. To improve the quality of HAE diagnostics, the Institute of Immunology jointly with Medical Genetics Centre started the work in order to develop and introduce the methods of genetic screening of patients with recurrent angioedema into the national practice. In the world as well as in Russian medical practice a new generation of medicines for the treatment of HAE attacks has been appeared. Integrated assessment of the problems of diagnostics and treatment of HAE and their consistent solution will significantly improve the quality of life of HAE patients.
Russian Journal of Allergy. 2011;8(3):14-18
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THE INFLUENCE OF TOPICAL GLUCOCORTICOSTEROIDS ONCYTOKINE GENE EXPRESSION IN THE SKIN AND PERIPHERALBLOOD OF ATOPIC DERMATITIS PATIENTS
Filimonova T.M., Elisyutina O.G., Fedenko E.S., Burmenskaya O.V., Boldyreva M.N., Filimonova T.M., Elisyutina O.G., Fedenko E.S., Burmenskaya O.V., Boldyreva M.N.
Abstract
Background. To investigate the influence of mometasone furoate 0,1% cream on cytokine gene expression in the skin and peripheral blood of atopic dermatitis (AD) patients comparing with control. Material and methods. 40 AD patients were included in the study and divided into 2 groups. group 1 patients were given continuous course of mometasone furoate 0,1% cream treatment for 14 days. group 2 patients were given indifferent emollient elobase cream for 14 days. Clinical efficacy of the treatment was assessed on the following features: SCORAD index, Investigators global Assessment (IgA) score and subjective assessment of itch and dryness of the skin according to skin area to be studied. Skin samples and peripheral blood of atopic dermatitis were used as material for immunological study. Interleukin (IL)1B, IL2, IL2r, IL4, IL5, IL6, IL7, IL8, IL10, IL 12A, IL12B, IL15 (total), IL15 , IL17A, IL18, IL23, IL28, IL29, Interferon (IFN)-ƒ, Tumor necrosis factor (TNF), Transforming growth factor beta 1 (TGFB1), forkhead box P3 (FOXP3) gene expression were defined in the skin and peripheral blood of AD patients by realtime reverse transcription polymerase chain reaction (RT-pCR). Results. positive clinical effect was found with all AD patients on the mometasone furoate 0,1% cream therapy background for 14 days and also dryness, rushes and skin itch decreased. Stаtistical significant decrease of proinflammatory cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN-ƒ gene expression was marked. They are the markers of chronic inflammation and Th1 immune response. Studying peripheral blood after mometasone furoate 0,1% cream treatment increase of TGFB1, FOXP3 gene expression level was found. no significant changes of cytokine gene expression in AD patients, who got elobase cream were found. Conclusion. Antiinflammatory activity of mometasone furoate 0,1% cream was shown by its influence on proinflammatory cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN-ƒ gene expression in the skin and mechanisms of immune response in moderate and severe AD patients.
Russian Journal of Allergy. 2011;8(3):19-30
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REMOTE RESULTS OF SUBLINGUAL ALLERGENSPECIFICIMMUNOTHERAPY AT POLLINOSIS PATIENTS - FIVE YEARS'RESEARCH
Manzhos M.V., Fedenko E.S., Myagkova M.A., Keropyan G.A., Shkadov S.A., Peretrukhin A.I., Manzhos M.V., Fedenko E.S., Myagkova M.A., Keropyan G.A., Shkadov S.A., Peretruhin A.I.
Abstract
Background. The purpose of the work was to investigate remote and preventive results of sublingual allergenspecific immunotherapy (SLiT) at pollinosis patients. Methods. 25 patients at the age from 19 till 50 years old with an allergic rhinitis and asthma (35%) sensitized to artemisia were under the supervision. SLiT was administered in the period since September 2003 till May 2006 with pollen allergen («Sevapharma», Czech Republik). The average total dose of the allergen per one patient at the end of the third year was 189999 PNU. Clinical efficiency was estimated annually and in 30 months after discontinuation of SLiT. Frequency and intensity of symptoms during the pollen season, requirement for medicines, FEV1 parameters and results of prick tests were considered. Results. good and excellent results after three courses of immunotherapy demonstrated 23 patients (92%), satisfactory - 2 patients (8%). The results were remained at 22 patients (88%) within the next 30 months. at 3 patients (12%) increase of rhinoconjunctivitis symptoms was noted, and 3 (12%) showed expansion of a sensibilisation spectrum. Further increase of intensity and frequency of asthma symptoms, decrease in indicators FEV1 was not registered. Conclusion. SLiT is a highly effective method of treatment for patients with seasonal rhinitis and leads to the clinical results remaining more than 2 years at the majority of patients.
Russian Journal of Allergy. 2011;8(3):31-36
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DECLINE DYNAMICS OF STAHPYLOCOCCUS AUREUS SUSCEPTIBILITY TO ANTIBIOTICS IN CHILDREN WITH ATOPICDERMATITIS
Treneva M.S., Pampura A.N., Zaporozhtseva Z.V., Treneva M.S., Pampura A.N., Zaporozhtseva Z.V.
Abstract
Background. Staphylococus aureus (S. aureus) colonization is revealed in 87-90% patients with atopic dermatitis (aD). S. aureus antibiotic susceptibility differs within time. the study is aimed to investigate the dynamics of S.aureus susceptibility to antibiotics and time limitation of this process in children with aD. Methods. S. aureus susceptibility to 19 antibiotics was analyzed with 72 resistance patterns (31 initial and 41 repeated in 0,5-30 months) of 203 performed in 647 children with aD tested in 2007-2009 years. results. in a three year period (2007-2009) a negative correlation of S. aureus antibiotic susceptible strains prevalence versus months since initial pattern was revealed (R=−0,29 p<0,01; г=−0,29, p<0,003; ф=−0,23 p<0,003). prevalence of antibiotic susceptible strains prevailed initially more than two times over resistant one has become not reliable in 12 months. conclusion. a child with aD is needed to be set and clear up with anti-inflammatory and antibacterial therapy in a 12 months period past hospital check-up. the decrease of S. aureus antibiotic susceptible strains within this period could probably reduce the effect of the following antibacterial therapy.
Russian Journal of Allergy. 2011;8(3):37-40
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CHARACTERISTICS OF ANTENATAL AND POSTNATAL RISKFACTORS OF FOOD ALLERGY IN INFANTS
Denisova S.N., Belitskaya M.Y., Sentsova T.B., Kon' I.Y., Kirillova O.O., Denisova S.N., Belitskaya M.Y., Sentsova T.B., Kon` I.Y., Kirillova О.О.
Abstract
Aim. to analyze a family history of the allergic diseases, course of pregnancy and delivery in mothers, effect of concomitant diseases on the development and course of food allergy in infants. methods. We examined 471 infants with food allergy and different severity index of the atopic dermatitis (AD). Moderate and severe AD were more common at the age of 0-12 months old than at the age of 12-36 months old (80,9 and 55,6%, respectively). in boys of the 12-36 months severe course of the disease was more common then in girls at the same age (14,6 and 7,3%, respectively). We used SCORAD index for estimation of severity of AD. Results. positive family histories of the allergic diseases were revealed in 67,9 and 67,3% of the infants with moderate and severe course of AD, respectively. in the half of these infants allergic diseases were found in the maternal line. Disturbances of the pregnancy and delivery in mothers of the infants with and without AD were equal; however these disturbances were more common in mothers of the infants with severe AD. the postnatal risk factors of allergy were revealed in 11,7% of infants: prematurity (3,2%), prenatal hypotrophy (4,7%), intranatal asphyxia (2,3%), cephalohaematoma (1,5%). Conclusion. the positive family history of allergy was high in all infants with AD independently on the age of the appearance of first signs of food allergy. Mothers with pathological course of pregnancy and delivery more often had an infants with severe course of AD. prevalence of the postnatal risk factors in healthy and ill infants was equal.
Russian Journal of Allergy. 2011;8(3):41-47
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USE OF MOLECULAR GENETIC METHODS IN THE STUDY OF HEREDITARY PREDISPOSITION TO ATOPIC DISEASES INCHILDREN
Tyumentseva E.S., Petrova N.V., Balabolkin I.I., Pinelis V.G., Tumentseva E.S., Petrova N.V., Balabolkin I.I., Pinelis V.G.
Abstract
Background. Study of the аssociations of susceptibility genes to the development of atopic diseases in children. Materials and methods. All 325 examined children reside on the territory of the European part of Russia who by according to surveys, Russian by nationality. Analysis of polymorphism in genes of receptors ADRB2, GRL, ALOX5, genes of biotransformation - CYP1A1, CYP2C9, CYP2C19, GSTT1, GSTM1, NAT2 as well as the variants of the genes MTHFR and TNFA was performed in patients suffering from atopic disease and in healthy individuals. Using Multifactor Dimentionality Reduction method (MDR) it was defined the most significant model of genegene interaction for the development of atopic disease Results. Association of the development of atopic diseases with polymorphic variants of the genes: ALOX5 (VNTR) GRL (1220A > G) TNFA (-308G > A) CYP1A1 (6235T > C) and GSTM1 was identified in surveyed children. The highrisk alleles and genotypes of developing atopic diseases in pediatric patients were determined. Using Multifactor Dimentionality Reduction method (MDR) it was defined the most significant model of gene-gene interaction for the development of atopic disease, including ADRB2 (79 C >G), (46A > G), CYP2C19 (G681A) was defined. Conclusion. There were identified polymorphic variants of genes and important gene-gene interactions associated with development of atopic diseases in children.
Russian Journal of Allergy. 2011;8(3):48-55
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ALLERGIC RHINITIS AND IT'S IMPACT ON ASTHMA (ARIA 2008)(PART 10)
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Russian Journal of Allergy. 2011;8(3):56-64
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PHARMACOLOGICAL SUPERVISION: THE EUROPEAN EXPERIENCE
Gratsianskaya A.N., Gratsianskaya A.N.
Russian Journal of Allergy. 2011;8(3):65-67
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THE ROLE OF HIDDEN ALLERGENS IN CLINICAL ALLERGOLOGY. SCIENTIFIC DISCUSSIONS WITHIN PERMITTEDLIMITS
Luss L.V., Il'ina N.I., Latysheva T.V., Gratsianskaya A.N., Smiyan I.A., Luss L.V., Ilina N.I., Latysheva T.V., Gratsyanskaya A.N., Smyan I.A.
Abstract
There is a significant increase of allergic reactions to «hidden allergens». a large amount of allergens and different substances which can play a role of hidden allergens were found. however their role in side (including allergic) reactions is not clear yet. in this report there are data concerning medical and legal problems of «hidden allergens» we face in clinical practice.
Russian Journal of Allergy. 2011;8(3):68-72
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NEW FEATURES OF THE PHARMACOLOGICAL CONTROL OF ASTHMA
Nazarova E.V., Il'ina N.I., Nazarova E.V., Ilina N.I.
Abstract
traditionally, bronchial asthma (Ba) was considered as a disease of large and medium bronchi, but recently obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract. several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal place of airflow obstruction in patients with asthma. there are currently actively being developed devices for improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.
Russian Journal of Allergy. 2011;8(3):73-78
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CURRENT APPROACHES TO TREATMENT OF ALLERGIC RHINITIS
Astaf'eva N.G., Astafieva N.G.
Russian Journal of Allergy. 2011;8(3):79-92
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FOOD ALLERGY AND FOOD INTOLERANCE. REFERENCE TABLES AND RECOMMENDATIONS
Luss L.V., Luss L.V.
Abstract
data and tables after classification, a spectrum of food allergens, food additives and their role in development of a food allergy and food intolerance are presented. recommendations for the practical doctor on features of a diet are presented
Russian Journal of Allergy. 2011;8(3):93-100
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THE EFFICIENCY OF CELLULOSE POWDER EXTRACT IN COMPLEX THERAPY OF PATIENTS WITH POLLEN ALLERGICRHINITIS
Penechko E.M., Sizyakina L.P., Penechko E.M., Sizyakina L.P.
Abstract
Background. The aim of the study was evaluating of cellulose powder extract efficiency in complex therapy of patients with pollen allergic rhinitis. Methods. 30 patients with pollen allergic rhinitis in acute stage were investigated. all patients were divided into two groups. The patients of the 1st group received standard therapy. The patients of the 2nd group additionally received cellulose powder extract. Results. Taking the cellulose powder extract in complex therapy of pollen allergic rhinitis helps to decrease intensity of symptoms and to normalize the immune status. Conclusion. The results obtained in this investigation helps to make a conclusion about practicability of cellulose powder extract efficiency in complex therapy of pollen allergic rhinitis.
Russian Journal of Allergy. 2011;8(3):101-104
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CONGRESSES, CONFERENCES
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Russian Journal of Allergy. 2011;8(3):105-105
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INSTRUCTIONS FOR AUTHORS
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Russian Journal of Allergy. 2011;8(3):106-109
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