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NEW FEATURES OF THE PHARMACOLOGICAL CONTROL OF ASTHMA
- Authors: Nazarova EV1, Il'ina N.I.1, Nazarova EV2, Ilina NI2
-
Affiliations:
- Institute of Immunology
- Issue: Vol 8, No 3 (2011)
- Pages: 73-78
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.09.2011
- URL: https://rusalljournal.ru/raj/article/view/813
- DOI: https://doi.org/10.36691/RJA813
- ID: 813
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Abstract
traditionally, bronchial asthma (Ba) was considered as a disease of large and medium bronchi, but recently
obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract.
several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal
place of airflow obstruction in patients with asthma. there are currently actively being developed devices for
improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.
obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract.
several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal
place of airflow obstruction in patients with asthma. there are currently actively being developed devices for
improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.
Keywords
About the authors
E V Nazarova
Nataliya Ivanovna Il'ina
Email: instimmun@yandex.ru
E V Nazarova
Institute of ImmunologyInstitute of Immunology
N I Ilina
Institute of ImmunologyInstitute of Immunology
References
- Asthma. Quick asthma facts and The Faces of asthma. Geneva: World Health Organization; 2010. Available from: http://www. who.int/respiratory/asthma/en/.
- Green R.H., Brightling C.E., McKenna S., Hargadon B., Parker D., Bradding P. et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002, v. 360, р. 1715-1721.
- Saetta M., Di Stefano A., Rosina C. et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am. Rev. Respir. Dis. 1991, v. 143, p. 138-143.
- Саrrоll N., Cooke C., James А. The distribution of eosinophils аnd lymphocytes in the large аnd small alrways of asthmatics. Еur. Respir. J. 1997, v. 10, p. 292-300.
- Carroll N., Carello S., Cooke C. et al. Airway structure and inflammatory cells in fatal attacks of asthma. Eur. Respir. J. 1996, v. 9, p. 709-715.
- Chiesi Pharmaceutici SpA. Modulite®: the value of Chiesi_s technolgy in the treatment of asthma and COPD (online). Available from URL: hppt://www.chiesigroup.com. Accessed 2006, May 25.
- Hamid Q., Song Y., Kotsimbos T.C. et al. Inflammation of small airways in asthma. J. Allergy Clin. Immunol. 1997, v. 100, р. 44-51.
- Wagner E.M., Lui M.C., Wainmann G.G. et al. Peripheral lung resistance in normal and asthmatic subjects. Am. Rev. Respir. Dis. 1990, v. 141, р. 584-588.
- Mauad T., Silva LFF, Santos M.A. et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am. J. Respir. Crit. Care Med. 2004, v. 170, p. 857-862.
- Sorkness R.L. et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation J. Appl. Physiol, 2008, v. 104, p. 394-403.
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