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Vol 16, No 4 (2019)

Articles

Editorial

Khaitov R.M., Il'ina N.I., Latysheva E.A.
Russian Journal of Allergy. 2019;16(4):5-6
pages 5-6 views

Direct action of allergen on smooth muscle cells

Gushchin I.S.

Abstract

Own and published data substantiate the direct effect of the allergen on smooth muscle cells due to its interaction with fixed IgE antibodies on type I Fcε receptors (FcεRI) expressed on these cells. The effects of Fcε RI-mediated stimulation of smooth muscle cells in the form of activation of the contractile mechanism, as well as the production and secretion of pro-inflammatory cytokines, are considered. Establishing the value of FcεRI-mediated activation of smooth muscle cells in the allergic response remains the task of subsequent studies.
Russian Journal of Allergy. 2019;16(4):7-16
pages 7-16 views

Treatment of ragweed pollionosis using sublingual allergens

Ukhanova O.P., Ebzeeva I.I.

Abstract

Seasonal allergic rhinitis and conjunctivitis, caused by ragweed pollen in the south of Russia, are the most common reasons to take medical advice for sensitized patients from August to September. Sublingual immunotherapy (slASIT) using ragweed sublingual tablet «Ragvizax®», which was registered in Russia in 2019 provides qualified medical care for patients with ragweed pollen allergy. It is known that ASIT is the basic therapy, that modifies pollen allergy progression. Easy to use, high safety and efficacy profile of slASIT with «Ragvizax®» will help to improve allergists and patients compliance.
Russian Journal of Allergy. 2019;16(4):17-23
pages 17-23 views

Modern ways to improve effectiveness of food allergy treatment in children

Mukhortykh V.A., Revyakina V.A., Larkova I.A., Kuvshinova E.D.

Abstract

Aim. To evaluate the effectiveness and safety of a multi-strain probiotic in children with various clinical manifestations of food allergy. Materials and methods. Under the supervision there were 192 children aged from 3 months to 3 years with skin, gastrointestinal and combined (skingastrointestinal) manifestations of food allergies. Patients of the main group received complex therapy and a multistrain probiotic. Patients in the control group did not receive probiotic. Clinical assessment of symptoms during the treatment was conducted (initially and after 30 days). Results. The use of a multistrain probiotic in children with various clinical manifestations of food allergy during 30 days showed improvement of skin and gastrointestinal symptoms of food allergy. The overall effectiveness of therapy in children of the main group was 80.3% versus 68.6% in the control group. Probiotic tolerance was good; no adverse reactions were noted. Conclusion. The inclusion of a new generation probiotic in the complex therapy of food allergies helps to improve the course of the disease and increase the effectiveness of treatment.
Russian Journal of Allergy. 2019;16(4):24-29
pages 24-29 views

Clinical features of various phenotypes of atopic dermatitis

Elisyutina O.G., Litovkina A.O., Smolnikov E.V., Shtyrbul O.V., Fedenko E.S., Dvornikov A.S.

Abstract

Genetic predisposition, twophase immune response, T1 and T2 lymphocytes dysbalance, epidermal barrier dysfunction, trigger factors, antigens play an important role in the atopic dermatitis pathogenesis. Recently, genotypes, phenotypes of the disease, as well as the relationship of genetic factors, pathogenesis and clinical features of AD, which determine the phenotype of the disease, are actively studied. The purpose of this research was to evaluate the clinical features of different AD phenotypes. Materials and methods. The research was conducted as an open prospective study. 86 patients suffered from moderate and severe AD, including 25 children aged 2 to 18 years and 61 adults aged 19 to 54 years were involved. Patients in the skin allergy and immunopathology department of «The Institute of Immunology of the FMBA of Russia» in the period from 2012 to 2016 were observed. The followup period was at least 1 year. The inclusion criteria of this group were the ability to collect a full anamnesis, the allergological examination, assessment of the severity of the disease and the response to the therapy, the adequacy of the fulfilment of the doctor’s recommendations by the patients, including compliance with elimination measures, diet, rational skin care, as well as the use of topical treatment. All patients received standard therapy according to Russian and international clinical guidelines. The severity of the disease was assessed on the basis of SCORAD and IGA scales, effectiveness of topical treatment and adverse events frequency. Results. The main criteria for determining of AD clinical phenotypes were established: severity of the disease (based on SCORAD, IGA); frequency and duration of exacerbations; age of onset of the disease; secondary skin infection; concomitant respiratory allergic diseases and sensitization to different groups of allergens; resistance to therapy. Recurrent course of AD and resistance to standard topical corticosteroids therapy were observed in 8 (32%) children and in 20 (32.7%) adults. The results of examination of representative sample of patients allowed to identify and characterize several AD phenotypes: isolated uncomplicated AD - in 15% of patients; AD complicated by secondary infection and the presence of sensitization to bacterial or fungal allergens - in 7% of patients; AD accompanied by the concomitant respiratory allergic diseases and the presence of sensitization to food and respiratory allergens - in 29% of patients; extremely severe AD, accompanied by secondary infection, respiratory allergic diseases and polyvalent sensitization, resistance to therapy - in 36% of patients. Conclusion. Identification of the clinical phenotype allows to determine the patients on the grounds of the clinical characteristics and AD features, which can be useful for understanding the etiopathogenesis of the disease in a particular patient and can be the basis for development of personalized approaches to the diagnosis and treatment of AD.
Russian Journal of Allergy. 2019;16(4):30-41
pages 30-41 views

Surprises of food anaphylaxis: a clinical case

Lepeshkova T.S., Beltyukov E.K.

Abstract

Anaphylaxis is a severe systemic hypersensitivity reaction that is characterized by rapid onset and life-threatening respiratory and blood circulation problems. We present to your attention a clinical case of the polyvalent allergy development in a three-year-old child with repeated episodes of food anaphylaxis. The child was born and he constantly lives in central Russia, but has a profile of sensitization unusual for a Ural resident. The clinical case is described in detail in order to demonstrate the stages of a child’s life, on which sensitization was likely to be first formed, and later the manifestation of clinical symptoms arose. Determination of the sensitization profile by means of the component allergy diagnostics methods (ISAC, ImmunoCAP) showed that the boy is sensitized to a large number of food allergens, including milk and egg proteins; storage proteins for peanuts, soy, hazelnuts and sesame; proteins related to the nsLTP-proteins. The obtained results made it possible to recognize and differentiate true IgE-mediated sensitization, to propose the optimal therapeutic tactics and to select an elimination diet. Application of molecular allergy diagnostic methods is useful in clinical practice in case of patients with multivalent sensitization and a history of severe allergic reactions.
Russian Journal of Allergy. 2019;16(4):42-47
pages 42-47 views

Evaluation of the efficacy and safety of 10% intravenous immunoglobulin Privigen in real clinical practice

Khludova L.G., Manto I.A., Latysheva E.A., Latysheva T.V., Khaitov M.R.

Abstract

Relevance. Replacement therapy with human immunoglobulins is the leading pathogenetic method of treatment of primary immunodeficiency with impaired antibody synthesis. Currently, several preparations of human immunoglobulins for intravenous administration are available in Russia. Purposes. Evaluation of the efficacy and safety of Privigen immunoglobulin intravenous 10% liquid in real clinical practice within 12 clinical months. Methods. Twenty adults diagnosed with common variable immunodeficiency or X-linked agammaglobulinemia received intravenous Privigen® infusions (0.2-0.4 mg/kg) at 24±3 intervals over a 12-month period. The primary endpoint was the annual rate of infections and adverse events. Results. Sufficient level of IgG was achieved in most patients during the study. Severe adverse reactions during the treatment were not registered. Conclusions. High efficacy and safety of monthly replacement therapy in patients with primary immunodeficiency with impaired antibody synthesis has been demonstrated.
Russian Journal of Allergy. 2019;16(4):48-56
pages 48-56 views

Postnasal drip syndrome as a cause of cough in allergic rhinitis

Maximova A.V., Smolkin Y.S.

Abstract

The article deals with the problem of postnasal drip syndrome in allergic rhinitis and associated cough syndrome. Global statistics of the occurrence of this disease was analyzed. The basic mechanisms of postnasal drip and cough formation in allergic rhinitis are presented. The emphasis in diagnostics and therapeutic approaches is indicated. The modern possibilities of topical intranasal antihistamines using in the treatment of this condition are proposed.
Russian Journal of Allergy. 2019;16(4):57-65
pages 57-65 views

Х-linked lymphoproliferative syndrome. FEDERAL CLINICAL RECOMMENDATIONS, 2020

Balashov D.N., Roppelt A.A., Rumjantsev A.G., Shcherbina A.U.
Russian Journal of Allergy. 2019;16(4):66-77
pages 66-77 views

Andrei Dmitrievich Ado: a person, a scientist, a healthcare organizer

Skorokhodkina O.V., Ivanov A.Y.
Russian Journal of Allergy. 2019;16(4):78-82
pages 78-82 views
pages 83-87 views

Congresses, conferences

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Russian Journal of Allergy. 2019;16(4):88-88
pages 88-88 views

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