Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press130810.36691/RAJ.2020.16.4.001ArticlesСтатьиResearch ArticleDirect action of allergen on smooth muscle cellsПрямое действие аллергена на гладкомышечные клеткиGushchinIgor SГущинИгорь Сергеевич

доктор медицинских наук, профессор, член-корр. РАН, зав. отделом.

igushchin@yandex.ruNRC Institute of Immunology FMBA of RussiaФГБУ «ГНЦ Институт иммунологии» ФМБА России15082019164VOL 16, NO4 (2019)ТОМ 16, №4 (2019)71602042020Copyright ©; 2019, Pharmarus Print MediaCopyright ©; 2019, Фармарус Принт Медиа2019Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/1308

Own and published data substantiate the direct effect of the allergen on smooth muscle cells due to its interaction with fixed IgE antibodies on type I Fcε receptors (FcεRI) expressed on these cells. The effects of Fcε RI-mediated stimulation of smooth muscle cells in the form of activation of the contractile mechanism, as well as the production and secretion of pro-inflammatory cytokines, are considered. Establishing the value of FcεRI-mediated activation of smooth muscle cells in the allergic response remains the task of subsequent studies.

Собственными и литературными данными обоснована возможность прямого действия аллергена на гладкомышечные клетки за счет взаимодействия его с фиксированными IgE антителами на Fcε -рецепторах I типа (FcεRI), экспрессированных на этих клетках. Рассмотрены последствия FcεRI-опосредованной стимуляции гладкомышечных клеток в виде активации сократительного механизма, а также продукции и секреции провоспалительных цитокинов. Установление значения FcεRI-опосредованной активации гладкомышечных клеток в аллергическом ответе остается задачей последующих исследований.

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