Direct action of allergen on smooth muscle cells

Cover Page

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Own and published data substantiate the direct effect of the allergen on smooth muscle cells due to its interaction with fixed IgE antibodies on type I Fcε receptors (FcεRI) expressed on these cells. The effects of Fcε RI-mediated stimulation of smooth muscle cells in the form of activation of the contractile mechanism, as well as the production and secretion of pro-inflammatory cytokines, are considered. Establishing the value of FcεRI-mediated activation of smooth muscle cells in the allergic response remains the task of subsequent studies.

Full Text

Restricted Access

About the authors

Igor S Gushchin

NRC Institute of Immunology FMBA of Russia

Moscow, 115522, Russian Federation.


  1. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM et al. Eur Respir J. 2018;51(2). pii: 0751387. doi: 10.1183/13993003.51387-2007.
  2. Haahtela T. A biodiversity hypothesis. Allergy. 2019;74:1445-1456. doi: 10.1111/all.13763.
  3. Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, Chuang S. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2002;282(3):L520-L528. doi: 10.1152/ajplung.00343.2001.
  4. Гущин ИС. Изменение мембранного потенциала и напряжения гладкой мышцы при аллергических реакциях в отсутствие тучных клеток. Бюллетень экспериментальной биологии и медицины. 1966;(12):25-28
  5. Гущин ИС. Анафилактическая реакция деполяризованной гладкой мышцы. Патологическая физиология и экспериментальная терапия. 1967;(2):45-49
  6. Гущин ИС. Электрофизиологическое исследование анафилактической реакции изолированного предсердия в отсутствие ионов кальция. Патологическая физиология и экспериментальная терапия. 1969;(1):27-31
  7. Гущин ИС. Анафилаксия гладкой и сердечной мускулатуры. М.: Медицина; 1973
  8. Souhrada M, Souhrada JF. Mast Cells and Antigen Response of Airway Smooth Muscle. Respiration. 1983;44:215-224.
  9. Souhrada M, Souhrada JF. Immunologically induced alterations of airway smooth muscle cell membrane. Science. 1984;225:723-725.
  10. Metzger H. The high affinity receptor for IgE on mast cells. Clin Exp Allergy. 1991;21:269-279.
  11. Kinet JP. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu Rev Immunol. 1999;17:931-972.
  12. Sibilano R, Frossi B, Pucillo CE. Mast cell activation: a complex interplay of positive and negate signaling pathways. Eur J Immunol. 2014;44:2558-2566. DOI: 10.1002/ eji.201444546.
  13. Fc Receptors. M. Daeron, F. Nimmerjahn (eds.). Series: Current Topics in Microbiology and Immunology 382. Springer International Publishing; 2014. doi: 10.1007/9783-319-07911-0.
  14. Sutton BJ, Davies AM. Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII. Immunol Rev. 2015;268:222-235. doi: 10.1111/imr.12340.
  15. Bruhns P, Jonsson F. Mouse and human FcR effector functions. Immunol Rev. 2015;268:25-51. doi: 10.1111/imr. 12350.
  16. Kraft S, Kinet JP. New developments in FcεRI regulation, function and inhibition. Nat Rev Immunol. 2007;7:365-378. doi: 10.1038/nri2072.
  17. Dombrowiez D, Quatannens B, Papin JP, Capron A, Capron M. Expression of a functional FcεRI on rat eosinophils and macrophages. J Immunol. 2000;165:1266-1271. PMID: 10903725.
  18. Siraganian RP. Mast cell signal transduction from the high-affinity IgE receptor. Curr Opin Immunol. 2003;15:639-646.
  19. Siraganian RP, de Castro RO, Barbu EA, Zhang J. Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants. FEBS Lett. 2010;584:4933-4940. doi: 10.1016/j.febslet.2010.08.006.
  20. Siraganian RP, Zhang J, Suzuki K, Sada K. Protein tyrosine kinase Syk in mast cell signaling. Mol Immunol. 2002;38:1229-1233. doi: 10.1016/s0161-5890(02)00068-8.
  21. Redhu NS, Gounni AS. The high affinity IgE receptor (FcεRI) expression and function in airway smooth muscle. Pulm Pharmacol Ther. 2013;26:86-94. doi: 10.1016/j.pupt.2012.04.004.
  22. Gounni AS, Wellemans V, Yang J, Bellesort F, Kassiri K, Gangloff S, Guenounou M, Halayko AJ, Hamid Q, Lamkhioued B. Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function. J Immunol. 2005;175:2613-2621. doi: 10.4049/jimmunol.175.4.2613.
  23. Roth M, Tamm M. The effects of omalizumab on IgE-induced cytokine synthesis by asthmatic airway smooth muscle cells. Ann Allergy, Asthma Immunol. 2010;104:152-160. doi: 10.1016/j.anai.2009.11.022.
  24. Yamaguchi M, Lantz CS, Oettgen HC, Katona IM, Fleming T, Miyajima I, Kinet JP, Galli SJ. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med. 1997;185:663-672.
  25. MacGlashan D Jr, McKenzie-White J, Chichester K, Bochner BS, Davis FM, Schroeder JT, Lichtenstein LM. In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood. 1998;91:1633-1643.
  26. Gounni AS. The high-affinity IgE receptor (FcepsilonRI): a critical regulator of airway smooth muscle cells? Am J Physiol Lung Cell Mol Physiol. 2006;291:L312-L321.
  27. Kraft S, Kinet JP. New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol. 2007;7:365-378. doi: 10.1038/nri2072.
  28. Alphonse MP, Saffar AS, Shan L, HayGlass KT, Simons FE, Gounni AS. Regulation of the high affinity IgE receptor (Fc epsilonRI) in human neutrophils: role of seasonal allergen exposure and Th-2 cytokines. PLoS One. 2008;3:e1921. doi: 10.1371/journal.pone.0001921.
  29. Redhu NS, Saleh A, Shan L, Gerthoffer WT, Kung SK, Halayko AJ, Lamkhioued B, Gounni AS. Proinflammatory and Th2 cytokines regulate the high affinity IgE receptor (FcepsilonRI) and IgE-dependant activation of human airway smooth muscle cells. PLoS One. 2009;4:e6153. DOI: 10.1371/ journal.pone.0006153.
  30. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001;25:474-485. doi: 10.1165/ajrcmb.25.4.4522.
  31. Xia YC, Schuliga M, Shepherd M, Powell M, Harris T, Langenbach SY, Tan PS, Gerthoffer WT, Hogarth PM, Stewart AG, Mackay GA. Functional expression of IgG-Fc receptors in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2011;44:665-672. doi: 10.1165/rcmb.2009-037WC.
  32. Redhu NS, Shan LS, Gounni AS. Fcε receptor expression in human smooth muscle cells. Am J Respir Cell Mol Biol. 2012;46:559-560. doi: 10.1165/ajrcmb.46.4.559.
  33. Xia YC, Redhu NS, Moir lM, Koziol-White C, Ammit AJ, Al-Alwan L, Camoretti-Mercado B, Clifford RL. Proinflammatory and immunomodulatory functions of airway smooth muscle: emerging concepts. Pulm Pharmacol Ther. 2013;26:64-74. doi: 10.1016/j.pupt.2012.05.006.
  34. Kuo IY, Ehrlich BE. Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015;7(2):a006023. DOI: 10.1101/ cshperispect.a006023.
  35. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med. 2003;167(10):1360-1368. PMID: 12531777.
  36. Balhara J, Redhu NS, Shan L, Gounni AS. IgE regulates the expression of smMLCK in human airway smooth muscle cells. PLoS One. 2014;9(4):e93946. doi: 10.1371/journal. pone.0093946.
  37. Koziol-White OJ, Jia Y Baltus GA, Cooper PR, Zaller DM, Crackower MA, Sirkowski EE, Smock S, Northrup AB, Himes BE, Alves SE, Panettieri RA. Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. Br J Pharmacol. 2016;173:3080-3087. doi: 10.1111/bph.13550.
  38. Schrader JW, Moyer C, Ziltener HJ, Reinisch CL. Release of the cytokines colony-stimulating factor-1, granulocyte-macrophage colony-stimulating factor, and IL-6 by cloned murine vascular smooth muscle cells. J Immunol. 1991;146:3799-808. PMID: 2033251.
  39. Peebles RS Jr, Aronica MA. Proinflammatory Pathways in the Pathogenesis of Asthma. Clin Chest Med. 2019;40:29-50. doi: 10.1016/j.ccm.2018.10.014.
  40. Ярилин АА. TSLP (лимфопоэтин из стромы тимуса) - новый патогенетический фактор аллергии. Российский Аллергологический Журнал. 2008;(5):9-13
  41. Гущин ИС, Курбачева ОМ. Аллергия и аллергенспецифическая иммунотерапия. М.: «Фармарус Принт Медиа»; 2010
  42. Halayko AJ, Amrani Y. Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma. Respir Physiol Neurobiol. 2003;137:209-222. PMID: 14516727.
  43. Panettieri RA Jr. Airway smooth muscle: immunomodulatory cells that modulate airway remodeling? Respir Physiol Neurobiol. 2003;137:277-293. PMID: 14516732.
  44. Tliba O, Panettieri RA Jr. Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol. 2009;71:509-535. doi: 10.1146/annurev.physiol.010908.163227.
  45. Redhu NS, Saleh A, Lee HC, Halayko AJ, Ziegler SF, Gounni AS. IgE induces transcriptional regulation of thymic stromal lymphopoietin in human airway smooth muscle cells. J Allergy Clin Immunol. 2011;128:892-896.e2. DOI: 10.1016/j. jaci.2011.06.045.
  46. Redhu NS, Gounni AS. Function and mechanisms of TSLP/ TSLPR complex in asthma and COPD. Clin Exp Allergy. 2012;42:994-1005. doi: 10.1111/j.1365-2222.2011.03919.x.
  47. Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L375-L382. D0I:10.1152/ajplung.00045.2007.
  48. Kaur D, Doe C, Woodman L, Heidi Wan WY, Sutcliffe A, Hollins F, Brightling C. Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin. Chest. 2012;142:76-85. doi: 10.1378/chest.11-1782.
  49. Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity. 2001;14:801-811. DOI: 10.1016/ s1074-7613(01)00159-5.
  50. Lam M, Lamanna E, Bourke JE. Regulation of airway smooth muscle contraction in health and disease. Adv Exp Med Biol. 2019;1124:381-422. doi: 10.1007/978-981-13-5895-1_16.
  51. Roth M, Zhong J, Zumkeller C, S’ng CT, Goulet S, Tamm M. The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. PLoS ONE. 2013;8(2):e56015. doi: 10.1371/journal.pone.0056015.
  52. Елисеева ТИ, Туш ЕВ, Красильникова СВ, Кузнецова СВ, Ларин РА, Кубышева НИ и соавт. Метаболизм экстрацеллюлярного матрикса при бронхиальной астме (Обзор). Современные технологии в медицине. 2018;10(4):220-234. doi: 10.17691/stm2018.10.4.25



Abstract: 46

Article Metrics

Metrics Loading ...



Copyright (c) 2019 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies