Direct action of allergen on smooth muscle cells

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Abstract

Own and published data substantiate the direct effect of the allergen on smooth muscle cells due to its interaction with fixed IgE antibodies on type I Fcε receptors (FcεRI) expressed on these cells. The effects of Fcε RI-mediated stimulation of smooth muscle cells in the form of activation of the contractile mechanism, as well as the production and secretion of pro-inflammatory cytokines, are considered. Establishing the value of FcεRI-mediated activation of smooth muscle cells in the allergic response remains the task of subsequent studies.

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About the authors

Igor S Gushchin

NRC Institute of Immunology FMBA of Russia

Email: igushchin@yandex.ru
Moscow, 115522, Russian Federation.

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