Vol 8, No 6 (2011)

Background. To study features of cereal grasses pollen collected in region were the enterprise that is in charge of destruction of the chemical weapons is placed - Gorniy, Saratov region. Materials and methods. Object of the research was pollen of cereal grasses collected in regions, differed by the ecological characteristics: object for destruction of chemical weapon of Gorniy of the Saratov region (investigated region), Privolzhsky area of the Ivanovo area (ecologically favorable region) and near to а motorway, Istrinsky area of Moscow Region (ecologically unfavorable region). Definition of the maintenance of heavy metals in pollen of grasses was carried out by the method of invertion voltamperometry, by percentage of sprouted pollen grains and the morphological characteristics of pollen grains by microscopy. Results. In samples of pollen collected within object for destruction of the chemical weapon of Gorniy, the maintenance of lead, mercury, zinc and cadmium, in comparison with non-polluting area, and with average values across the Russian Federation, thus lead almost ten times above, in comparison with average values of the maintenance in plants across the Russian Federation is authentically increased. The morphological changes of pollen more expressed in ecologically adverse region are revealed: the quantity of abortive pollen grains near to а motorway was above more than ten times, and, within the enterprise for the object for destruction of the chemical weapon of Gorniy, almost in 3 times, in comparison with non-polluting region. It is established that along with heavy metals (lead and zinc) which are а part of the list of the harmful substances containing in emissions in atmosphere of the enterprise for the object for destruction of the chemical weapon of Gorniy, the increasing of mercury and cadmium levels which are absent in а production cycle is revealed and can t be connected with enterprise functioning. Possibly other sources of pollution render.on the mercury and cadmium maintenance . Conclusion. Thus, in experiments it has been shown that pollen of plants possesses considerable sorbtion capacity for the heavy render metals which are а part of harmful production factors which change bioindicator properties of plant pollen and could form hypersensitivity.

Background. The purpose of the work is to investigate the effectiveness and safety of the subcutaneous allergenspecific immunotherapy (scIT ) using F ostal at pollinosis children. Methods. 31 patient (19 boys and 12 girls) at the age from 5 to 16 with pollinosis with sensibilization to tree pollen (birch, alder, hazel) allergens were observed. A ll patients were divided into 2 groups. T he first group consisted of 11 children, which were treated with F ostal. T he second group was a control group, consisted of 20 children, no treatment was assigned to them. A ll patients from both groups got the basis pollinosis therapy. Efficiency of the scIT using F ostal was estimated in terms of its influence on the childrens quality of life, clinical symptoms and drug load. Results. Good results demonstrated in terms of increased quality of life indexes were achieved after the initial stage of the scIT using F ostal. C ompared to the control group, the amount of needed drugs was significantly decreased, and the decrease in the severity of clinical symptoms of rhinitis (p=0,001) and conjunctivitis (p=0,002) was observed. During the scIT with the F ostal trees pollen some negligible local reactions were observed in all cases, in 7 of 11 patients marked local reactions appeared. O n the initial stage of the therapy no systemic allergic reaction was observed. Conclusion. On the basis of the results of the study, F ostal could be considered as a highly effective and safe for treatment of pollinosis children. S cIT with the F ostal leads to the improvement of childrens quality of life, decreasing of clinical symptoms severity as well as drug load.

In the article possible immunological mechanisms of feeding influence on the health status are discussed. Importance of breast feeding for preventive maintenance of allergic diseases, as well as effectiveness of modern mixes enriched by prebiotics is underlined.

Background. To investigate the efficiency, safety of inert cellulose powder in allergic rhinitis, and influence on mucous tunic of nasal cavity. Materials and methods. Two groups of patients were examined in this research (30 healthy volunteers and 30 patients suffering from allergic rhinitis). The following factors of patients' life and health condition were evaluated during the investigation: quality of life, the condition of mucous tunic, mucociliary clearance rate, the ciliabeat frequency of ciliated cylindrical epithelium, the signs of inflammation in the smears of mucous tunic before and after the treatment with Nazaval and Nazaval Plus. The results. Nazaval and Nazaval Plus improved the quality of life index and reduced the inflammation signs of mucous tunic of nasal cavity examined by rhinoscopy and endoscopy. No ciliotoxic effects of preparations on mucous tunic were established. Conclusion. The inert cellulose powder is a highly effective and safe product for the treatment of allergic rhinitis.

Background. The clinical efficiency and safety of tacrolimus ointment 0,1%, accessible in the Russian market since 2011, in moderate and severe atopic dermatitis (AD) were investigated. The assessment was based on the data of tacrolimus using in routine clinical practice under the registered indication. Methods. There were 19 moderate and 11 severe AD patients under supervision. Treatment with tacrolimus ointment 0,1% was started with twice a day application. Duration of this treatment was from 1 to 4 weeks (18±4,2 days) up to skin clearance. When symptoms were reduced, the frequency of tacrolimus application was reduced as well to once a day daily, and than to twice a week. Generally, improvement was observed within one week of treatment. Clinical efficiency was assessed by SCORAD index and Investigators' Global Assessment (IGA). Results. Positive clinical effect of tacrolimus 0,1% ointment therapy was found in 90% of AD patients resulted in significant reduction of dryness, rushes, skin itch, SCORAD and IGA indexes. Conclusion. Tacrolimus 0,1% ointment is effective and safe for treatment of severe and moderate AD. It should be applied both as exacerbations treatment and as maintenance therapy in AD patients.