Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press76710.36691/RJA767ArticlesСтатьиAtopic dermatitis: experimentalmodels for study of pathogenesis and development of new methods of treatmentАтопический дерматит: экспериментальные модели для изучения патогенеза и разработки новых методов леченияShershakovaN NШершаковаН Н

ФГБУ «ГН Ц Институт иммунологии» ФМБ А России

nsh18.81@mail.ruBabakhinA AБабахинА А

ФГБУ «ГН Ц Институт иммунологии» ФМБ А России

ElisyutinaO GЕлисютинаО Г

ФГБУ «ГН Ц Институт иммунологии» ФМБ А России

KhaitovM RХаитовМ Р

ФГБУ «ГН Ц Институт иммунологии» ФМБ А России

ShershakovaN N

Institute of Immunology

BabakhinA A

Institute of Immunology

ElisyutinaO G

Institute of Immunology

KhaitovM R

Institute of Immunology

ФГБУ «ГН Ц Институт иммунологии» ФМБ А РоссииInstitute of Immunology1512201186NO6 (2011)№6 (2011)31110032020Copyright ©; 1970, Pharmarus Print MediaCopyright ©; 1970, Фармарус Принт Медиа1970Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/767

Atopic dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is dry itchy skin due, at least in part, to defects in skin genes that are important for maintaining barrier function. The pathogenesis of AD remains incompletely understood. A number of mouse models of AD have been developed. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation. Also, we describe various approaches to the treatment of atopic dermatitis, the latest of which is the introduction of siRN A. Development of drugs based on siRN A using functional peptides is a promising area of research in allergology.

Атопический дерматит (АтД) является широко распространенным аллергическим воспалительным заболеванием кожи. Возникновение АтД отчасти может быть следствием генетически обусловленных нарушений барьерной функции кожи. Патогенез АтД не полностью изучен. Разработан ряд «мышиных» моделей АтД. В данном обзоре обсуждаются основные экспериментальные модели АтД и подчеркивается роль механического повреждения кожи и дисфункции кожного барьера, способствующие аллергическому кожному воспалению. Кроме того, описаны различные подходы к лечению АтД, новейшим из которых является введение малых интерферирующих РНК (миРНК ). Разработка лекарственных средств на основе миРНК с использованием функциональных пептидов является перспективным направлением в создании препаратов нового поколения в терапии АтД.

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