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Tacrolimus in moderate and severeatopic dermatitis treatment. The first clinical experience in Russia
- Authors: Elisyutina O.G.1, Fedenko ES1, Shtyrbul OV1, Niyazov DD1, Elisyutina OG2, Fedenko ES2, Shtyrbul OV2, Niyazov DD2
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Affiliations:
- Institute of Immunology
- Issue: Vol 8, No 6 (2011)
- Pages: 68-76
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/822
- DOI: https://doi.org/10.36691/RJA822
- ID: 822
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Abstract
Methods. There were 19 moderate and 11 severe AD patients under supervision. Treatment with tacrolimus ointment 0,1% was started with twice a day application. Duration of this treatment was from 1 to 4 weeks (18±4,2 days) up to skin clearance. When symptoms were reduced, the frequency of tacrolimus application was reduced as well to once a day daily, and than to twice a week. Generally, improvement was observed within one week of treatment. Clinical efficiency was assessed by SCORAD index and Investigators' Global Assessment (IGA). Results. Positive clinical effect of tacrolimus 0,1% ointment therapy was found in 90% of AD patients resulted in significant reduction of dryness, rushes, skin itch, SCORAD and IGA indexes.
Conclusion. Tacrolimus 0,1% ointment is effective and safe for treatment of severe and moderate AD. It should be applied both as exacerbations treatment and as maintenance therapy in AD patients.
About the authors
Ol'ga Gur'evna Elisyutina
Email: el-olga@yandex.ru
E S Fedenko
O V Shtyrbul
D D Niyazov
O G Elisyutina
Institute of ImmunologyInstitute of Immunology
E S Fedenko
Institute of ImmunologyInstitute of Immunology
O V Shtyrbul
Institute of ImmunologyInstitute of Immunology
D D Niyazov
Institute of ImmunologyInstitute of Immunology
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