Experienceof subcutaneous allergen-specific immunotherapy with «Phostal» in children.

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Abstract


Background. The purpose of the work is to investigate the effectiveness and safety of the subcutaneous allergenspecific
immunotherapy (scIT ) using F ostal at pollinosis children.
Methods. 31 patient (19 boys and 12 girls) at the age from 5 to 16 with pollinosis with sensibilization to tree pollen
(birch, alder, hazel) allergens were observed. A ll patients were divided into 2 groups. T he first group consisted
of 11 children, which were treated with F ostal. T he second group was a control group, consisted of 20 children,
no treatment was assigned to them. A ll patients from both groups got the basis pollinosis therapy. Efficiency of
the scIT using F ostal was estimated in terms of its influence on the childrens quality of life, clinical symptoms
and drug load.
Results. Good results demonstrated in terms of increased quality of life indexes were achieved after the initial
stage of the scIT using F ostal. C ompared to the control group, the amount of needed drugs was significantly
decreased, and the decrease in the severity of clinical symptoms of rhinitis (p=0,001) and conjunctivitis (p=0,002)
was observed.
During the scIT with the F ostal trees pollen some negligible local reactions were observed in all cases, in 7 of 11
patients marked local reactions appeared. O n the initial stage of the therapy no systemic allergic reaction was
observed.
Conclusion. On the basis of the results of the study, F ostal could be considered as a highly effective and safe
for treatment of pollinosis children. S cIT with the F ostal leads to the improvement of childrens quality of life,
decreasing of clinical symptoms severity as well as drug load.

About the authors

Natal'ya Viktorovna Shakhova

Email: Natalia.shakhova@mail.ru

V V Gordeev

V P Tokarev

T Yu Borisenko

S S Kharchenko

E N Kurenkova

N V Shakhova

Altai State Medical University

Altai State Medical University

V V Gordeev

Altai State Medical University

Altai State Medical University

V P Tokarev

Сity clinical children's hospital № 7

Сity clinical children's hospital № 7

T Y Borisenko

Сity clinical children's hospital № 7

Сity clinical children's hospital № 7

S S Kharchenko

Сity clinical children's hospital № 7

Сity clinical children's hospital № 7

E N Kurenkova

Сity clinical children's hospital № 7

Сity clinical children's hospital № 7

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