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Vol 9, No 1 (2012)

Articles
Editorial
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Russian Journal of Allergy. 2012;9(1):3-4
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Allergy to latex - current state of problem
Evdokimova T.A., Fedorova O.S., Fedotova M.M.
Abstract
During the last 20 years the incidence of sensitization to latex proteins is growing. Allergy to latex is found predominantly in persons, professionally contacting with latex products: medical workers, workers employed in the manufacture of rubber products and food workers. This review describes the main clinical symptoms of latex allergy, characteristics of structural proteins and their basic biological functions. Modern methods of diagnostics and approaches to the application of specific immunotherapy for allergy to latex are presented.
Russian Journal of Allergy. 2012;9(1):5-11
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Sublingual immunotherapy - questions of efficiency and safety
Manzhos M.V., Fedenko E.S., Myagkova M.A.
Abstract
The basic results of clinical researches on efficacy and safety studying sublingual allergenspecific immunotherapy (slASIT) are presented in the review. The results of SUBLINGUAL application of allergens in Russian Federation are presented.
Russian Journal of Allergy. 2012;9(1):12-20
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The basic markers of neutrophilic inflammation in severe bronchial asthma (the literature review)
Goryachkina L.A., Biteeva D.V., Fomina D.S.
Abstract
In spite of the marked insights of modern medicine into the pathogenesis of bronchial asthma, there is unresolved issue regarding achievement of therapeutic control. Understanding of the immunopathogenesis of the disease resulted in a subdivision into different biological phenotypes due to dominating inflammatory component, characterized by list of biological markers. A role of neutrophilic inflammation in bronchial asthma has been widely discussed in recent studies but is still uncertain. In general, asthma associated with neutrophils tends to be a more aggressive disease with more tissue destruction and airway remodeling; tightly associated with lower response to corticosteroids treatment, moreover, it could be induced by it.
Russian Journal of Allergy. 2012;9(1):21-28
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Group of Investigators for ERAs Program, Russia. Allergic rhinitis and asthma in real clinical practice in Russia: multicenter clinical study
Emelyanov A.V., Goryachkina L.A., Astafeva N.G., Fassakhov R.S., Chernyak B.A., Abelevich M.M., Ignatova G.L., Kudelia L.M., Zhestkov A.V., Leschenko I.V., Sobko E.A., Alexeenko V.A., Burlachuk V.T., Lobanov K.I., Frolova S.A., Galimova E.S., Khassanova R.B., Koroleva M.G.
Abstract
The aim of the study which included 2311 patients (aged 18—80 yrs), examined by 100 physicians (57% allergists, 37% pulmonologists and 7% general practitioner) in 18 Russian cities, was to assess the prevalence of allergic rhinitis in patients with asthma, as well as to evaluate the specifics of the course of these diseases, when concomitant or not. The study design included one outpatient visit, followed by the completion of studyspecific case report forms and Asthma Control Questionnaire (ACQ) validated for use in Russia. The vast majority (88%)of asthma patients had concomitant allergic rhinitis (Group 1). Patients with asthma only (Group 2) were older (50,6±0,78 vs 41,9±0,35 yr, p<0,05, had more severe asthma course (FEV t 70,6±1,1 vs 78,3±0,46% of predicted, p<0,05), lower prevalence of atopy (45% vs 98%, p<0,05) , higher body mass index (BMI) (28,2±0,27 vs 27,3±0,12, p<0,05), and smoked more often compared to Group 1 (30% vs 23%, p<0,05). The treatment of concomitant allergic rhinitis recommended in current clinical guidelines may improve asthma control. Significant proportions of patient with asthma (27%) and allergic rhinitis (41%) were treated not in line with evidence-based International and National Guidelines. The conclusion of this study is that allergic rhinitis is a common comorbidity in patients with asthma. The implementation of the evidence based approach to diagnosis and treatment of both diseases, in accordance with current clinical guidelines, in real clinical practice in Russia is extremely important.
Russian Journal of Allergy. 2012;9(1):29-36
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Clinical and pathogenetic aspects of bronchial asthma with mycotic sensitization among residents of Siberia, Yakutia and the Russian Far East
Lazutkina E.L., Muzychenko L.M., Landyshev Y.S., Tsyrendorzhiev D.D., Chaplenko T.N.
Abstract
Background. Is to investigate clinical and pathogenetic features of bronchial asthma (BA) in residents of Siberia, Yakutia, and Russian Far East with mycotic sensitization. Materials and Methods. 45 BA patients in the age group of 24—58 year-olds have been checked. Among them 245 patients were residents of Amur region, 112 patients — residents of Novosibirsk region, and 86 — of the Republic of Yakutia (SAHA), the City of Mirniy. All the patients went through a complex clinical and allergological checkup. The results were processed with «STATISTICA 6» set of programs. Results of the research. Variation in mycotic sensitization in BA patients has proved to be region-bound. Conclusion. Mycotic sensitization in BA patients is marked by predominantly severe clinical course of bronchial asthma and high levels of IgE in the patients’ serum. In the Republic of Yakutia (SAHA) the number of such patients is higher than in Amur and Novosibirsk regions. In BA patients — residents of Amur and Novosibirsk regions — mycotic allergy is accompanied by the domestic one, while in Yakutia it is observed along with epidermal sensitization.
Russian Journal of Allergy. 2012;9(1):37-41
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Arterial dysfunction and systemic inflammation in patients with bronchial asthma
Sobko E.A., Kraposhina A.Y., Ischenko O.P., Demko I.V., Salmina A.B., Burakov A.Y., Prugova V.L.
Abstract
Background. The objective of this study was to estimate a vascular wall status of large arteries and function of endothelium in patients with different clinical forms of bronchial asthma throughout the disease progression. 220 patients with bronchial asthma have been examined, including 106 persons with moderate asthma ( 1 st group), 61 persons with severe asthma (2 nd group), and 53 persons with steroid-dependent asthma. Control group was formed from 40 healthy donors. Methods. We have assessed parameters of external respiration, arterial rigidity, and the levels of TNFα, IL-6, sCD31 (sPECAM-1), CRP in the peripheral blood at the time of exacerbation and 48 weeks later. Results. We found elevation of IL-6 and TNFα levels in all the tested groups in the period of exacerbation comparing to the control group (p<0,05), thus confirming development of SIRS. We have registered increased levels of sCD31 (sPECAM-1) in all the tested groups suggesting development of endothelial dysfunction. Increase in aorta rigidity in patients with asthma has been manifested by elevation of pulse wave velocity and augmentation index. Conclusion. We have demonstrated that the degree of arterial rigidity and endothelial dysfunction could be used as indicators of systemic inflammation being corresponded to the alterations in external respiration in asthma patients.
Russian Journal of Allergy. 2012;9(1):42-49
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Multiple faces of bronchial asthma - phenotypes and clinical pathogenetic variants
Fedoseev G.B., Trofimov V.I., Shailieva L.O., Eliseeva M.V., Kriakunov K.N.
Abstract
The article discusses heterogeneity of bronchial asthma from points of view of etiology, pathogenesis, clinical peculiarities and treatment approaches. The multiple faces of the disease are represented by different cellular phenotypes and clinical pathogenetic variants. The article gives arguments for use of clinical pathogenetic variants in evaluation of the inflammation type and choice of personalized treatment. To evaluate cellular phenotypes and clinical pathogenetic variants complex investigations are to be performed in bronchial asthma patients.
Russian Journal of Allergy. 2012;9(1):50-57
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Pneumococcal infection in children of early age from risk groups: preventive maintenance possibilities
Salkina O.A., Snegova N.F., Ilina N.I., Tchernousov A.D., Kostinov M.P.
Abstract
The Article is devoted to an actual problem of modern public Healthcare — Pneumococcal infections and possibilities of their prophylaxis. Background. To develope the effective and safe specific prevention method of pneumococcal disease in children of risk groups with the use of conjugated and polysaccharide-based vaccines. Materials and methods. 285 children of both genders aged from 6 months to 5 years old with various deviations in health status and risk factors of development of invasive pneumococcal disease were included in the study. Children from the main group (n=218) were immunized by the seven-valent pneumococcal conjugate vaccine (PCV7), part of children (n=31) were primary vaccinated by PCV7 later and received a boost dose of polysaccharide vaccine (PPV-23), children in the control group (n=36) were once immunized by PPV-23. Safety, clinical and immunological effectiveness of various schemes of vaccination were evaluated. Results. Frequency of adverse events to the introduction of PCV7 such as fever were up to 6.4%, local reactions — 4,6%. The majority of children (87—89%), immunized with PCV7 had elevated level of specific antibodies in more than 3 times compairing to the control group. In children vaccinated with PCV7, the number of pneumonia cases decreased to 6.8 times, acute average otitis — to 3,5 times, ARD — to 1,3 times.
Russian Journal of Allergy. 2012;9(1):58-65
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Assessment of Rosaceae sensitisation diagnostics in allergic children
Pampura A.N., Konjukova N.G., Fedenko E.S., Havkin A.I., Okuneva T.S.
Abstract
Background. Sensitization to the fruits of the family Rosaceae is widespread in children population, but its diagnostics is often difficult. Methods. The study included 190 children with suspected allergy to the fruit family of Rosaceae. Results. The presence of sensitization was found in 148 patients. Qualitatively, the results of in vitro and in vivo tests with allergens differed approximately one third of cases. Among children with sensitization to the fruits of a family Rosaceae specific IgE to rBet v 1 was identified approximately in 3/4, rPru p 3 — in 2/3, rBet v 2 — in 1/5 of patients. Conclusion. The results indicate a high informative determination of specific IgE (ImmunoCap, Phadia AB) to the fruits of Rosaceae (apple, pear, peach) and a recombinant allergens (rBet v 1, rBet v 2, rPru p 3).
Russian Journal of Allergy. 2012;9(1):66-72
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Allergic conjunctivitis in children: from pathogenesis to therapy
Leppenen N.E., Pampura A.N.
Abstract
In the article data about classification, pathogenesis, clinical manifestations and treatment of different forms of allergic conjunctivitis in children are presented.
Russian Journal of Allergy. 2012;9(1):73-78
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Experience of lordestin (desloratadine) use in patients with seasonal allergic rhinitis
Ilyina N.I., Pavlova K.S.
Abstract
The article presents the results of the study of the Lordestin's (desloratadine) efficacy and safety in patients with seasonal allergic rhinitis. The results showed that Lordestin is highly effective in reducing of the severity of nasal and ocular symptoms in patients with hay fever, has a good safety profile and may be recommended as a monotherapy or as a component of combination therapy in patients with allergic rhinitis.
Russian Journal of Allergy. 2012;9(1):79-83
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Clinical and immunological characteristics ofpatients with polyvalent food allergy in reasoning of clinical prescribing of amino acid formula
Varlamov E.E., Okuneva T.S., Pampura A.N.
Abstract
Methods: 117 infants with atopic dermatitis and food allergy were enrolled. The analysis of clinical and immunological characteristics of the infants with multiple food intolerance was performed. Results: asthma, high levels of specific IgE to cow milk, egg, beef, pork, sensitization to allergens of cereals, fruits and vegetables were characterized for infants with multiple food intolerance. Conclusion: infants with multiple food intolerance possess defined clinical and immunological characteristics which can form the basis for prescribing of amino acid formula.
Russian Journal of Allergy. 2012;9(1):84-87
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Congresses, Conferences
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Russian Journal of Allergy. 2012;9(1):88-90
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Instructions for Authors
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Russian Journal of Allergy. 2012;9(1):91-93
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