The basic markers of neutrophilic inflammation in severe bronchial asthma (the literature review)



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Abstract

In spite of the marked insights of modern medicine into the pathogenesis of bronchial asthma, there is unresolved issue regarding achievement of therapeutic control. Understanding of the immunopathogenesis of the disease resulted in a subdivision into different biological phenotypes due to dominating inflammatory component, characterized by list of biological markers. A role of neutrophilic inflammation in bronchial asthma has been widely discussed in recent studies but is still uncertain. In general, asthma associated with neutrophils tends to be a more aggressive disease with more tissue destruction and airway remodeling; tightly associated with lower response to corticosteroids treatment, moreover, it could be induced by it.

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About the authors

L A Goryachkina

Russian Medical Academy of Post-graduate education

Clinical Allergology Department

D V Biteeva

Russian Medical Academy of Post-graduate education

Clinical Allergology Department

D S Fomina

Russian Medical Academy of Post-graduate education

Email: dinadok@mail.ru
Clinical Allergology Department

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