Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press69310.36691/RJA693ArticlesСтатьиResearch ArticleThe basic markers of neutrophilic inflammation in severe bronchial asthma (the literature review)Основные маркеры нейтрофильного воспаления при бронхиальной астме тяжелого теченияGoryachkinaL AГорячкинаЛ АBiteevaD VБитееваД ВFominaD SФоминаД Сdinadok@mail.ruRussian Medical Academy of Post-graduate educationГосударственное бюджетное образовательное учреждение дополнительного профессионального образования российская медицинская академия последипломного образования (ГБОУ ДПО РМАПО Минздравсоцразвития россии)1502201291NO1 (2012)№1 (2012)212810032020Copyright ©; 2012, Pharmarus Print MediaCopyright ©; 2012, Фармарус Принт Медиа2012Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/693

In spite of the marked insights of modern medicine into the pathogenesis of bronchial asthma, there is unresolved issue regarding achievement of therapeutic control. Understanding of the immunopathogenesis of the disease resulted in a subdivision into different biological phenotypes due to dominating inflammatory component, characterized by list of biological markers. A role of neutrophilic inflammation in bronchial asthma has been widely discussed in recent studies but is still uncertain. In general, asthma associated with neutrophils tends to be a more aggressive disease with more tissue destruction and airway remodeling; tightly associated with lower response to corticosteroids treatment, moreover, it could be induced by it.

Несмотря на достигнутые успехи в изучении патогенетических механизмов бронхиальной астмы (БА), нерешенным остается вопрос о достижении полного контроля заболевания. Понимание иммунологических и патогенетических особенностей заболевания привело к выделению различных биологических фенотипов астмы, основанных на доминирующем паттерне воспаления, характеризующемся рядом биологических маркеров. Роль нейтрофильного компонента в развитии БА широко обсуждается, но по-прежнему оставляет больше вопросов, чем ответов. нейтрофильный фенотип БА ассоциируется с агрессивным течением заболевания, выраженной деструкцией тканей, характеризуется низким ответом на кортикостероиды и, в свою очередь, может быть обусловлен их действием.

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