Arterial dysfunction and systemic inflammation in patients with bronchial asthma



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. The objective of this study was to estimate a vascular wall status of large arteries and function of endothelium in patients with different clinical forms of bronchial asthma throughout the disease progression. 220 patients with bronchial asthma have been examined, including 106 persons with moderate asthma ( 1 st group), 61 persons with severe asthma (2 nd group), and 53 persons with steroid-dependent asthma. Control group was formed from 40 healthy donors. Methods. We have assessed parameters of external respiration, arterial rigidity, and the levels of TNFα, IL-6, sCD31 (sPECAM-1), CRP in the peripheral blood at the time of exacerbation and 48 weeks later. Results. We found elevation of IL-6 and TNFα levels in all the tested groups in the period of exacerbation comparing to the control group (p<0,05), thus confirming development of SIRS. We have registered increased levels of sCD31 (sPECAM-1) in all the tested groups suggesting development of endothelial dysfunction. Increase in aorta rigidity in patients with asthma has been manifested by elevation of pulse wave velocity and augmentation index. Conclusion. We have demonstrated that the degree of arterial rigidity and endothelial dysfunction could be used as indicators of systemic inflammation being corresponded to the alterations in external respiration in asthma patients.

Full Text

Restricted Access

About the authors

E A Sobko

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Email: sobko29@mail.ru
Krasnoyarsk

A Y Kraposhina

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

O P Ischenko

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

I V Demko

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

A B Salmina

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

A Y Burakov

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

V L Prugova

Krasnoyrsk state medical university named arter prof. V.F. Voino-Yasenersky, ministry of public health service and social development of the Russian Federation Regional Clinical Hospital

Krasnoyarsk

References

  1. Овсянников Н.В. и соавт. Фармакоэкономические аспекты терапии болезней органов дыхания. Фармакоэкономические исследования как основа повышения эффективности здравоохранения: монография. Омск. 2004, с. 175-193.
  2. Лев Н.С. Патогенетическая роль оксида азота при бронхиальной астме. Рос. вестн. перинатологии и педиатрии. 2000, № 4, с. 48-51.
  3. Рывкин А.И. и соавт. Состояние микроциркуляции при бронхиальной астме у детей. Педиатрия. 2005, № 6, с. 7-12.
  4. Artlich A. et al. Childhood asthma: exhaled nitric oxide in relation to clinical symptoms. Eur. Res. J. 1999, v. 13, No. 6, р. 1396-1401.
  5. Cohn J.N., Quyyumi A.A., Hollenberg N.K. et al. Markers of malign across the cardiovascular continuum: interpretation and application. Surrogate Markers for Cardiovascular Disease. Functional Markers. Circulation. 2004, v. 109, р. 31-46.
  6. Kass D.A. Ventricular arterial stiffening. Integrating the Pathophysiology. Fifth International Workshop on Structure and Function of Large Arteries. Hypertension. 2005, v. 46, р. 185-191.
  7. Laurent S., Katsahian S., Fassot C. et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003, v. 34, No. 5, р. 1203-1206.
  8. Zieman S. J., Melenovsky V., Kass D. A. Mechanisms, pathophysiology, and therapy of arterial stiffness. Atheroscler. Thromb. Vasc. Biol. 2005, v. 25, No. 5, p. 932-943.
  9. Гельцер Б.И., Бродская Т.А., Невзорова В.А. Оценка артериальной ригидности у больных хронической об-структивной болезнью легких. Пульмонология. 2008, № 1, с. 45-50.
  10. Бродская Т.А., Гельцер Б.И., Невзорова В.А. и соавт. Клинико-функциональная оценка артериальной ригидности при бронхиальной астме. Клин. мед. 2007, № 6, с. 17-23.
  11. Sabit R., Bolton C.E., Edwards P.H. et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2007, v. 175, p. 1259-1265.
  12. Weber T, Auer J., O’Rourke M.F. et al. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation. 2004, v. 109, p. 184-189.
  13. Kampus P, Muda P., Kals J. et al. The relationship between inflammation and arterial stiffness in patients with essential hypertension. Int. J. Cardiol. 2006, v. 112, № 1, р. 46-51.
  14. Debra K., Newton-Nash and Newman P. J. A New Role for Platelet Endothelial Cell Adhesion Molecule-1 (CD31): Inhibition of TCR-ediated Signal Transduction1. The Journal of Immunology. 1999, v. 163, р. 682-688.
  15. Takemura M., Matsumoto H., Niimi A. et al. High sensitivity C-reactive protein in asthma. Eur. Respir. J. 2006, v. 27, No. 5, р. 908-912.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright © Pharmarus Print Media, 2012



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies