Clinical and pathogenetic aspects of bronchial asthma with mycotic sensitization among residents of Siberia, Yakutia and the Russian Far East



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Abstract

Background. Is to investigate clinical and pathogenetic features of bronchial asthma (BA) in residents of Siberia, Yakutia, and Russian Far East with mycotic sensitization. Materials and Methods. 45 BA patients in the age group of 24—58 year-olds have been checked. Among them 245 patients were residents of Amur region, 112 patients — residents of Novosibirsk region, and 86 — of the Republic of Yakutia (SAHA), the City of Mirniy. All the patients went through a complex clinical and allergological checkup. The results were processed with «STATISTICA 6» set of programs. Results of the research. Variation in mycotic sensitization in BA patients has proved to be region-bound. Conclusion. Mycotic sensitization in BA patients is marked by predominantly severe clinical course of bronchial asthma and high levels of IgE in the patients’ serum. In the Republic of Yakutia (SAHA) the number of such patients is higher than in Amur and Novosibirsk regions. In BA patients — residents of Amur and Novosibirsk regions — mycotic allergy is accompanied by the domestic one, while in Yakutia it is observed along with epidermal sensitization.

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About the authors

E L Lazutkina

Amur State Medical Academy

Email: amurlaz@mail.ru
Russia

L M Muzychenko

SRI Molecular Biology and Biophysics RAMS

Yu S Landyshev

Amur State Medical Academy

Russia

D D Tsyrendorzhiev

SRI Clinical Immunology RAMS

T N Chaplenko

Amur State Medical Academy

Russia

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