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Vol 9, No 2 (2012)

Articles
THE PREVALENCE AND STRUCTURE OF ALLERGIC DISEASES IN ATHLETES OF THE HIGHEST ACHIEVEMENTS
Shartanova N.V.
Abstract
Background. To identify the prevalence of allergic diseases, characteristics of the spectrum of allergens in athletes of the highest achievements. Materials and Methods. 417 athletes of the highest achievements were examined (members of the Russian Federation national teams of different sports). To assess the allergic status of the athletes allergological, pharmacological, nutritional histories were collected. Also we used skin prick tests with various groups of allergens, identification of allergen-specific IgE in serum (indicated) to confirm allergy. Results. Among the athletes of highest achievements a high prevalence of AD (24,5%) was revealed. In 20,3% latent sensitization was determined. The sensitization to the domestic and epidermal allergens was predominant (90,2%). In the spectrum of pollen allergens in 62,5% of athletes sensitization to Compositae and Chenopodiaceae pollen was dominated. In structure of AD AR occurred in 50%, hay fever — in 20,5%, urticaria — in 13,7%, drug allergy — in 10,8%, asthma — in 7,8%. Conclusion. Early detection and adequate therapy of AD in athletes will significantly improve the health level and athletic performance.
Russian Journal of Allergy. 2012;9(2):3-8
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MUTATION C3435T IN MULTI-DRUG RESISTANCE GENE MDR1 AS PHARMACOGENETIC MARKER OF SEVERE COURSE OF BRONCHIAL ASTHMA
Mironova Z.A., Trofimov V.I., Iantchina Е.D., Ulitina A.S., Dubina М.V.
Abstract
Background. Early detection and treatment of severe forms of bronchial asthma (BA) is one of serious problems in clinical practice. BA is a multifactorial disease, so its progression is a result of both environmental factors and genetic predisposition. Aim of the study. To determine frequencies of genetic variants resulted from the mutation C3435T (rs1045642) in MDR1 gene among patients with different BA severity and in healthy controls. Methods. The trial included 122 patients with different severity of BA course and 103 healthy controls. Genomic DNA was extracted from peripheral blood leucocytes by routine phenol-chloroform protocol. Allelic variants were determined by polymerase chain reaction with subsequent restriction analysis with MboI restriction endonuclease. Results. For the first time association of allelic variant 3435C of MDR1 gene with BA was revealed. Differences between MDR1 genotypes distributions persisted in case of stratification BA patients according their severity courses. Severity of BA course was found to be strongly associated with 3435C allele. Conclusion. Allele 3435C and genotype 3435CC of gene MDR1 are markers of increased risk of BA progression. In patients with BA these alleles are associated with unfavorable severe course of the disease. Genotype 3435TT of gene MDR1 is a protective marker associated with favorable and well-controlled BA course.
Russian Journal of Allergy. 2012;9(2):9-12
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ANTIHISTAMINE THERAPY EFFICACY IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA
Golubchikova R.N., Danilycheva I.V.
Abstract
Background. Estimation of efficacy of antihistamines in patients with various severity levels and various clinical and laboratory variants of chronic idiopathic urticaria (CIU) . Methods. The retrospective study of the anamnestic clinical laboratory findings in 196 patients with CIU was performed. Results. The frequency of patients with full effect of antihistamines was 69%, partial efficacy — 11%, lack of efficacy — 20%. Lack of efficacy was dominated in patients with severe course of the disease and the presence of clinical manifestations of autoimmune disorders, non-specific inflammation and / or signs of cutaneous vasculitis. The full effect of antihistamines was dominated in patients with mild to medium CIU, with a normal clinical blood count and with a negative skin test with autologous serum. Conclusion. Lack of efficacy of of antihistamines in patients with severe course of disease, signs of autoimmune disorders specify on others nonhistamine mediators in CIU pathogenesis and application of the second and third line therapy of CIU.
Russian Journal of Allergy. 2012;9(2):13-18
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ATOPIC DERMATITIS IN CHILDREN: PREAND PERINATAL RISK FACTORS
Belan E.B., Gavrikov L.K., Kasyanova A.S., Khlynova N.A., Sadchikova T.L., Gutov M.V.
Abstract
Background. To study the influence of some pre- and perinatal factors on risk of atopic dermatitis development in children up to 3 years old. Materials and methods. 460 newborns and children histories up to 3 years old as well as pregnancy and delivery medical reports of their mothers have been analyzed. The data were estimated differentially depending on presence or absence of atopic dermatitis in 3 years old children. Results. The most significant perinatal risk factors for development of atopic dermatitis were: family history of atopy in mother (OR 3,99 [95% CI 2,38; 6,72]), gestosis, fetoplacentary insufficiency (OR 1,65 [95% CI 1,08; 2,54]), threat of interruption of pregnancy failure (OR 1,82 [95% CI 1,21; 2,74]), fed by a milk formulas (OR 1,70 [95% CI 1,13; 2,56]), cytomegalovirus (OR 1,56 [95% CI 1,02; 2,41])and ureaplasma infection in anamnesis (OR 1,77 [95% CI 1,10; 2,78]), and antibiotics (macrolids) intake during pregnancy. Conclusions. The influence of some pre- and perinatal risk factors of atopic dermatitis in children of early age has been demonstrated.
Russian Journal of Allergy. 2012;9(2):19-22
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CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF RECURRENT OBSTRUCTIVE BRONCHITIS IN CHILDREN
Lukashevich М.G., Siziakina L.P., Savisko A.A.
Abstract
Background. The aim of the study is to evaluate immunopathogenic mechanisms of lower respiratory tract reobstructions and to develop diagnostic, treatment and prophylaxis mechanisms of this syndrome and transformation to BA. Methods. 78 children with repeated episodes of obstructive bronchitis (OB) and 30 conditionally healthy children, formed a control group, were examined. Both groups of children were divided into two age groups — under 3 years old and older than 3 years old. All the patients underwent immunological examination. Results. The longer and heavier course of OB episodes, accompanied by the disturbance of ripening and, in less degree, differentiation of T-lymphocyte subpopulation, decreasing of readiness for apoptosis were revealed in 3 years old patients. In the age group older than 3 years old the OB episodes were taking their course easier, started at the earlier age, repeated more often, were accompanied by decreasing of CD4 +-lymphocytes, decreasing of early activation processes, intensification of late activation processes. Conclusion. The revealed peculiarities testify to heterogeneity of children groups with repeated OB episodes and make working out individual rehabilitation programs necessary.
Russian Journal of Allergy. 2012;9(2):23-27
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BRONCHIAL ASTHMA. WHAT IS IT POSSIBLE TO DO FOR ACHIEVEMENT OF CONTROL OF THIS DISEASE?
Kurbacheva O.M.
Abstract
Bronchial asthma is the disease extended around the world, having optimized medical approaches to which maintaining, it is possible to reduce it’s influence on the patient and society. Approaches applied now to a cumulative assessment of asthma burden are unreliable: doctors underestimate real weight of a disease at the patients receiving antiasthmatic therapy, and patients overestimate extent of control of the disease. However, control of bronchial asthma can be reached with treatment according to the modern recommendations. Article is devoted to some aspects of the combined anti-inflammatory therapy of bronchial asthma by various pharmacological means and their combinations.
Russian Journal of Allergy. 2012;9(2):28-34
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ATOPIC DERMATITIS: DIAGNOSTICS FEATURES
Macharadze D.S.
Abstract
Atopic dermatitis (AD) — a chronic inflammatory skin disease with a broad spectrum of clinical symptoms. It is diagnosed mainly clinically. Sensitization to inhalled and food allergens may play a role in the development of AD. Thus, it is important to determine the presence of sensitization for environmental control and allergen avoidance, pharmacotherapy, and immunotherapy.
Russian Journal of Allergy. 2012;9(2):35-44
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A EUROPEAN DECLARATION ON IMMUNOTHERAPY. COMBATING ALLERGY BEYOND SYMPTOMS. PART 1
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Abstract
На последнем ежегодном конгрессе в Стамбуле Европейская академия аллергологии и клинической иммунологии (EAACI) представила «Европейскую декларацию по аллерген-специфической иммунотерапии» (European Declaration on Allergen Immunotherapy). Этот документ (выпущенный совместно с Европейской федерацией ассоциаций пациентов, страдающих аллергией и болезнями дыхательных путей (EFA) и Европейской глобальной сетью по аллергии и астме (GA 2LEN)) адресован лицам, ответственным за принятие решений в области здравоохранения во всех европейских государствах, и является сильным аргументом в пользу преимуществ более широкого использования аллерген-специфической иммунотерапии (АСИТ) в здравоохранении. Эта декларация представляет собой интерес также и для российских специалистов, ассоциаций пациентов и лиц, отвечающих за разработку политики и планирование в сфере медицины и здравоохранения. В России, где традиции аллерген-специфической иммунотерапии насчитывают многие десятилетия, уровень общественной осведомленности о данном методе не так высок. Лучшая информированность как пациентов, так и врачей будет служить более широкому признанию данного метода и предотвращению дальнейшего развития аллергических заболеваний. Появление нового поколения препаратов, более безопасных и удобных в использовании, будет, безусловно, этому способствовать.
Russian Journal of Allergy. 2012;9(2):45-50
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DIET EFFICACY IN BREAST FEEDING CHILD WITH FOOD ALLERGY
Malanicheva T.G., Denisova S.N.
Abstract
Цель. Изучить эффективность современной адаптированной формы на основе новозеландского козьего молока «Нэнни 1 с пребиотиками», «Нэнни 2 с пребиотиками» у детей грудного возраста, находящихся на искусственном вскармливании, с кожными и гастроинтестинальными формами пищевой аллергии. Материалы и методы. Обследованы 50 детей в возрасте от 1 мес до 1 года с пищевой аллергией, находящихся на искусственном вскармливании. Пациентам проводились сбор аллергологического анамнеза, углубленное клиническое, параклиническое обследования, определение в сыворотке крови уровня общего IgE и аллерген-специфических IgE (acIgE) к белкам коровьего молока и казеину. Диетотерапия пищевой аллергии у детей грудного возраста заключалась в замене употреблявшейся ранее смеси на современные адаптированные формулы на основе новозеландского козьего молока «Нэнни 1 с пребиотиками» детям до 6 мес и «Нэнни 2 с пребиотиками» — детям от 6 до 12 мес. Эффективность проводимой терапии оценивали на основе динамики клинических симптомов заболевания, а также снижения уровня общего IgE и acIgE к белкам коровьего молока и казеину. Клиническую эффективность диетотерапии в комплексном лечении кожных и гастроинтестинальных форм пищевой аллергии оценивали на основе общего терапевтического эффекта (ОТЭ) и индивидуального терапевтического эффекта (ИТЭ). Результаты. Применение адаптированной смеси «Нэнни 1 с пребиотиками» или «Нэнни 2 с пребиотика-ми» в составе комплексной противоаллергической терапии приводит к положительному клиническому эффекту в 74% случаев, достижениию ремиссии атопического дерматита и гастроинтестинальной аллергии на 10—20-й день от начала лечения на фоне снижения уровня общего IgE и асIgE к белкам коровьего молока и казеину. При этом обеспечиваются адекватный рост и физическое развитие детей на первом году жизни.
Russian Journal of Allergy. 2012;9(2):51-54
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APPLICATION OF DECONGESTANTS IN THE TREATMENT OF ALLERGIC RHINITIS
Sobolev A.V., Fedoskova T.G.
Abstract
Efficiency of application of a preparation xylometazoline is shown in the treatment of allergic rhinitis (AR). Expediency of xylometazoline inclusion in symptomatic therapy of patients having clinical manifestations of AR is noted.
Russian Journal of Allergy. 2012;9(2):55-60
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THERAPEUTIC APPROACHES TO THE URTICARIA TREATMENT
Shvets S.M.
Abstract
Urticaria is a heterogenic disorder, requires elimination of triggers and symptomatic treatment. The basic medications are antihistaminics of the second generation.
Russian Journal of Allergy. 2012;9(2):61-64
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THE IMPORTANCE OF EARLY ALLERGIC RHINITIS DIAGNOSIS IN THE PREVENTION OF IT’S COMPLICATIONS
Sobolev A.V., Aak O.V.
Abstract
Background. Determination of prevalence of allergic rhinitis in patients with an allergy in the practice of an allergist, identification of the range of sensitization to common allergens in patients of different age groups, demonstration of the early diagnosis importance. Materials and methods. Determination of specific IgE in serum by MAST-HLA panels (36 allergens, Russian Panel IV, Hitachi Diagnostics, USA) was performed for 610 patients with rhinitis. For 269 of them a comprehensive clinical examination including cytological, bacteriological and mycological study of nasal swab was carried out. Results. Allergic rhinitis was diagnosed in 55,9% of the patients, infectious rhinitis was found in 28,7%, non-allergic rhinitis with eosinophilia syndrome is set in 6,1% of individuals. IgE to pollen was present in 53,9% of cases, to house dust— in 45,0% to house dust mites — in 29,0%, to mold allergens — in 14,5%. The frequency of children sensitization com -pared with adults to dog’s epithelium was higher by 1,4 times, the cat’s epithelium — by 1,3 times, to cockroaches — by 1,8 times, to house dust mites — by more than 2-fold, to food — by 2—3-fold. The clinical case demonstrates the importance of early diagnosis of disease. The choice of medicines for treatment was discussed. Conclusion. Given that the debut of allergic rhinitis in most of the examined patients occurred in childhood, the early examination of allergy in children is reasonable for the purpose of adequate therapy.
Russian Journal of Allergy. 2012;9(2):65-68
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PROPHYLACTIC BARRIER IN ALLERGIC RHINITIS
Tarasova G.D., Zayceva O.V., Torgovanova E.A.
Abstract
Цель. Определить лечебную эффективность и безопасность препарата «Назаваль» у больных, страдающих круглогодичным аллергическим ринитом (АР). Материалы и методы. В исследовании приняли участие 43 больных круглогодичным АР, в возрасте от 2,5 до 57 лет — 17 мужчин и 26 женщин. Обследование включало сбор анамнеза, общий и оториноларин-гологический осмотр. Пациентам рекомендовали использовать средство «Назаваль» за 15—20 мин до предполагаемого контакта с причинно-значимым аллергеном. Результаты. Установлена клиническая эффективность и безопасность применения средства «Назаваль», направленного на снижение симптоматики заболевания. Установленная клиническая эффективность исследуемого средства составила 81,4%.
Russian Journal of Allergy. 2012;9(2):69-72
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EXPRESSION OF CYTOKINES GENES PARAMETERS IN SKIN AND BLOOD OF SEVERE ATOPIC DERMATITIS AND T-CELL SKIN LYMPHOMA PATIENTS
Niyazov D.D., Fedenko E.S., Boldyreva M.N.
Russian Journal of Allergy. 2012;9(2):73-76
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CD56 +-CELLS IN BLOOD IN PATIENTS WITH ALLERGY: AGE AND GENDER FEATURES
Souzdaltseva T.V., Souzdaltseva N.A., Vechkanova N.N.
Russian Journal of Allergy. 2012;9(2):77-78
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ROLE OF MOLECULES OF ADHESION IN TERM INFANTS WITH THE RESPIRATORY DISTRESS SYNDROME
Dudareva M.V., Sizjakina L.P., Dudarev I.V.
Russian Journal of Allergy. 2012;9(2):79-81
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MODERN PRINCIPLES OF DIAGNOSTICS OF AN ALLERGY TO SINANTROPNY ARTHROPODS
Fedoskova T.G., Luss L.V., Fedoseeva V.N., Berzhets V.M., Ksenophontova V.A.
Russian Journal of Allergy. 2012;9(2):82-83
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ALLERGEN-SPECIFIC IMMUNOTHERAPY: RENEWED RESPONSE TO THE WELL-KNOWN stimulus
Gushchin I.S.
Russian Journal of Allergy. 2012;9(2):86-89
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CONGRESSES, CONFERENCES
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Russian Journal of Allergy. 2012;9(2):90-91
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INSTRUCTIONS FOR AUTHORS
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Russian Journal of Allergy. 2012;9(2):92-95
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