ATOPIC DERMATITIS IN CHILDREN: PREAND PERINATAL RISK FACTORS



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Abstract

Background. To study the influence of some pre- and perinatal factors on risk of atopic dermatitis development in children up to 3 years old. Materials and methods. 460 newborns and children histories up to 3 years old as well as pregnancy and delivery medical reports of their mothers have been analyzed. The data were estimated differentially depending on presence or absence of atopic dermatitis in 3 years old children. Results. The most significant perinatal risk factors for development of atopic dermatitis were: family history of atopy in mother (OR 3,99 [95% CI 2,38; 6,72]), gestosis, fetoplacentary insufficiency (OR 1,65 [95% CI 1,08; 2,54]), threat of interruption of pregnancy failure (OR 1,82 [95% CI 1,21; 2,74]), fed by a milk formulas (OR 1,70 [95% CI 1,13; 2,56]), cytomegalovirus (OR 1,56 [95% CI 1,02; 2,41])and ureaplasma infection in anamnesis (OR 1,77 [95% CI 1,10; 2,78]), and antibiotics (macrolids) intake during pregnancy. Conclusions. The influence of some pre- and perinatal risk factors of atopic dermatitis in children of early age has been demonstrated.

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About the authors

E B Belan

Volgograd State Medical University

Email: belan05@mail.ru
Pediatrics and Neonatology dept. Russia

L K Gavrikov

Volgograd State Medical University

Pediatrics and Neonatology dept. Russia

A S Kasyanova

Volgograd State Medical University

Pediatrics and Neonatology dept. Russia

N A Khlynova

Volgograd State Medical University

Pediatrics and Neonatology dept. Russia

T L Sadchikova

Volgograd State Medical University

Pediatrics and Neonatology dept. Russia

M V Gutov

Volgograd State Medical University

Pediatrics and Neonatology dept. Russia

References

  1. Andrew C., Krakowski M.D., Lawrence F., Magdalene A. et al. Management of Atopic Dermatitis in the Pediatric Population. Pediatrics. 2008, v. 122, p. 812-824.
  2. Тренева М.С., Пампура А.Н. Влияние малозначимых факторов на развитие атопических заболеваний у детей. Тез. II Всерос. конгр. по детской аллергологии. М., «Мед-практика». 2003, с. 197-198.
  3. Флетчер Р, Флетчер С., Вагнер Э. Клиническая эпидемиология. Основы доказательной медицины. Пер. с англ. М., «Медиа Сфера». 1998, 352 с.
  4. Полетаев А.Б. Гинекология: экстрагенитальная патология и беременность. Практическая медицина. 2003, № 3, с. 21-26.
  5. Jchows W, Perera F., Rachel L. et al. Intrauterine exposure to lead may enhance sensitization to common inhalant allergens in early childhood: A prospective prebirth cohort study. Environmental Research. 2011, v. 111, p. 119-124.
  6. Kirk E., Bora H., Condous G., Timmerman D. et al. Chlamydia trachomatis infection in patients attending an Early Pregnancy Unit: Prevalence, symptoms, pregnancy location and viability. Acta Obstetricia et Gynecologica Scandinavica. 2008, v. 87, p. 601-607.
  7. Duff P. Diagnosis and Management of CMV Infection in Pregnancy. J. Perinatology. 2010, v. 1, p. 1-6.
  8. Silveira M.F., Ghanem K.G., Erbelding E.J. et al. Chlamydia trachomatis infection during pregnancy and the risk of preterm birth: a case-control study. Int. J. STD AIDS. 2009, v. 20, p. 465-469.
  9. Dom S., Droste J.H., Sariachvili M.A., Hagendorens M.M. et al. Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years. Clin. Exp. Allergy. 2010, v. 40, p. 1378-1387.
  10. Pesola G.R., Iqbal J., Damian. The Hygiene Hypothesis and the Primary Prevention of Allergic Diseases. The Internet Journal of Asthma, Allergy and Immunology. 2005, v. 3, p. 31.
  11. Koplin J., Allen K., Gurrin L. et al. Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. Pediatr. Allergy Immunol. 2008, v. 19 (8), p. 682-687.
  12. Hagendorens M.M., Bridts C.H., Lauwers K., Ebo D.G. et al. Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study). J. Clin. Exp. Allergy. 2005, v. 35 (6), p. 733-740.
  13. Moore, M.D., Megan M., Sheryl L., Ken P at al. Prenatal Predictors of Atopic Dermatitis Occurring in the first six months of life. J. Pediatrics. 2004, v. 113, p. 468-474.
  14. Raimondi F., Indrio F., Crivaro V., Araimo G. et al. Neonatal hyperbilirubinemia increases intestinal protein permeability and the prevalence of cow’s milk protein intolerance. Acta Pediatrica. 2008, v. 97, p. 751-753.
  15. Arshad S.H. Primary prevention of asthma and allergy. J. Allergy Clin. Immunol. 2005, v. 116, p. 3-143-144.

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