Vol 7, No 3 (2010)

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics. Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.

Background. To study the efficiency of irrigation and topical corticosteroids in the treatment of patients with PNDS in allergic and non-allergic (vasomotor) rhinitis. Methods. Two groups, twelve patients each, at the age of 16 till 65, with allergic and non-allergic rhinitis participated in the investigation. All patients have firstly undergone the irrigation therapy with isotonic marine solution, after that the course of intranasal corticosteroid therapy (ICST) with fluticason propionate was provided during 14 days. Results. The levels of subjective sensations and objective symptoms were the same during and after the irrigation therapy in both groups (p>0,05). The reduction of subjective and objective symptoms was registered in both groups during ICST on the 14th day of treatment (p<0,01). Two weeks after, the reduction of symptoms was registered only in group of patients with allergic rhinitis (p<0,05). Conclusion. The irrigation therapy doesn't lead to a considerable decreasing of PNDS symptoms level, while ICST are briefly effective and can be coursed used in periods of severe symptoms of PNDS.

In the article the modern approaches to diagnostics of food allergy with the focus on other thenlgE-related forms of gastrointestinal hypersensitivity in infants are described. The results of the own study on efficacy assessment of new diagnostic system - immune-enzyme assay «Lactest» for specific IgE and IgG levels against food allergens as well as proteins from baby food estimation in sera of infants are presented. Dietotherapy for infants with food allergy based on immune-enzyme assay «Lactest» is described.

The purposes of the study. The primary purpose was to show antihistaminic efficiency of Histafen in a daily doze of 150 mg per os within 14 days at patients with chronic urticaria (ChU) on an example of suppression of the skin reaction caused by histamin. The secondary purposes: To estimate a condition of microcirculation in the skin of patients with ChU during Histafen treatment and to confirm safety and absence of sedative effect of Histafen. Materials and methods of study. There were 20 adult patients (men and women) in the age from 18 to 55, with exacerbation of ChU included in the study; 20 healthy persons - as a control group. We made clinic and laboratory examination to all patients, including skin pricktitration with histamin, research of local microcirculation in a skin. Sedative effect estimated on the change of stability of attention by means of B. Burdon's proof test and volume of attention by Shulte tables. Results. Histafen suppression of the skin urticaria and hyperemia which was caused by histamine in ChU patients was established: for 50% and 40% respectively. However these results are statistically doubtful - p=0,27 and p=0,18 respectively. The revealed changes of local microcirculation in the skin can testify to normalization of basal blood-groove parameters in skin of patients with ChU. Absence of sedative effect during of Histafen treatment was established: absence of statistically approved changes in parameters of volume of attention (p=0,6) and authentic improvement of stability of attention after the treatment (p=0,01) was noted. The conclusion. The study demonstrated high antihistaminic activity of Histafen, its safety and absence of sedative effect in patients with ChU.