Antimicrobial peptides is antimicrobial protection factors in atopic dermatitis and pyodermiapatients

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Abstract


It is well known that atopic dermatitis patientsґ skin is highly contaminated with S. aureus. On the one hand
S. aureus can cause pyodermia, and on the other hand it is a classical allergen and can initiate IgE production.
Also patientsґ skin is contaminated with some other bacteria, fungi and viruses. This predisposition to a skin
infection arises, at least, partly, because of a defect in protection against the microbes, named innate immunity.
One component of innate immune system are antimicrobial peptides: defensins and cathelicidin LL- 37. Human
defensins are peptides with cysteine structure, they are found out in circularly neutrophiles. Defensins are effective
against a wide spectrum of microorganisms, including gram-negative, gram-positive bacteria, fungi and some
viruses. Except their direct antimicrobial function, defensins have multiple roles as mediators of inflammation,
have chemotactic, immunomodulating and cytotoxic activity and others as well. It is proved that the b-defensins
and cathelicidin LL- 37 level is decreased in atopic dermatitis patients and can predispose to microorganisms
colonization on a skin of this patients. The level of antimicrobial peptides is increased in infected skin.

About the authors

E A Tsyvkina

Institute of Immunology

Institute of Immunology

E S Fedenko

Institute of Immunology

Institute of Immunology

B V Pinegin

Institute of Immunology

Institute of Immunology

References

  1. Хаитов P.M., Игнатьева Г.А., Сидорович И.Г. Иммунология. М., «Медицина». 2002. с. 536.
  2. Хаитов P.M. Физиология иммунной системы. М., «ВИНИТИ РАН». 2001. с. 7-8.
  3. Richard L. Gallo, MD, PhD, Masamoto Murakami, MD, PhD, Takaaki Ohtake, MD, PhD et al. Biology and clinical relevance of naturally occurring antimicrobial peptides. J. allergy and clinical immunology. 2002, v. 110, No. 6, p. 823-831.
  4. Siegbert Rieg, Heiko Steffen, Silke Seeber et al. Deficiency of dermi-cidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. The journal of immunology. 2005, No. 174, p. 8003-8010.
  5. БудихинаАС. Оценка бактерицидной активности биологических жидкостей в норме и при патологии с помощью лазерной проточной цитометрии. Диссертация канд. мед. наук. М., 2007.
  6. Philpott M. Defensins and acne. Mol. Immunol. 2003, v. 40 (7), p. 457-462.
  7. Wehkamp J. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proceedings of the National Academy of Sciences of the United States of America. 2005,v. 102 (50), p. 18129-18134.
  8. БудихинаАС, ПинегинБ.В. р-дефензины: свойстваифункции. Рос. Аллергол. Журн. 2008, № 3, с. 15-21.
  9. Starner T.D., Agerberth В., Gudmundsson G.H. et al. Expression and activity of {betaj-defensins and LL-37 in the developing human lung. J. Immunol. 2005, v. 174 (3), p. 1608-1615.
  10. Selsted M.E., Brown D.M., DeLange R.I., Lehrer R.I. Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J. Cell Biol. Chem.1983, v. 258, p. 14485-14489.
  11. Yamaguchi Y, Nagase Т., Makita R. et al. Identification of multiple novel epididymis-specific b-defensin isoforms in humans and mice. J. Immunol. 2002, v. 169, p. 2516-2523.
  12. Howell M.D. The role of human beta defensins and cathelicidins in atopic dermatitis. Current Opinion in Allergy & Clinical Immunology. 2007, v. 7 (5), p. 413-417.
  13. Kao C.Y, ChenY, ZhaoYH. etal. ORFeome-based search of airway epithelial cell-specific novel human p-defensin genes. Am. J. Respir. Cell Mol. Biol. 2003, v. 29, p. 71-80.
  14. Хаитов P.M., Игнатьева Г.А., Сидорович И.Г. Иммунология. М., «Медицина». 2000, с. 67-68.
  15. Lehrer R, Ganz T. Antimicrobial polypeptides of human neutrophils. J. ofAmerican Society of Hematology. 1990, v. 76, No. 11, p. 2169-2181.
  16. Дьяконова B.A., Пак B.Г., Будихина АС. и соавт. Оценка функциональной активности фагоцитарной системы человека в норме и при патологии. Пособие для врачей клинической лабораторной диагностики. М., 2008. с. 29.
  17. Befus A.D., Mowat С, Gilchrist M. et al. Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. J. Immunol. 1999, v. 163, p. 947-953.
  18. Jenssen H., Hamill P., Hancock R.E.W. Peptide antimicrobial agents. Clinica microbiology reviews, 2006, v. 19, No. 3, p. 491-511.
  19. Dunsche A, Acil Y, Siebert R. et al. Expression profile of human defensins and antimicrobial proteins in oral tissues. J. Oral Patol. Med. 2001, v. 30, p. 154-158.
  20. Jones D.E., Bevins C.L. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 1992, v. 267, p. 23216-23225.
  21. O'Neil D.A., Porter E.M., Elewaut D.etal. Expression and regulation of the human betadefensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 1999, v. 163, p. 6718-6724.
  22. Edgerton M., Koshlukova S.E., Lo Т.Е. et al. Candidacidal activity of salivary histatine. Identification of a histatin 5-binding protein on Candida albicans. J. Biol Chem. 1998, v. 273, p. 20438-20447.
  23. Wehkamp J., Harder J., Wehkamp K. et al. NF-kB and AP-1-mediated induction of human beta-defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917a novel effect of a probiotic bacterium. Infect. Immun., 2004, v. 72, No. 10, p. 5750-5758.
  24. Moser C, Weiner D.J., Lysenko E. et al. Betadefensin 1 contributes to pulmonary innate immunity in mice. Infect. Immun., 2002, v. 70, p.3068-3072.
  25. Ishimoto H., Mukae H., Date Y et al. Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia Eur. Respir J. 2006, v. 27, p. 253-260.
  26. Hiratsuka Т., Nakazato M., Date Y et al. Identification of human beta-defensine-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun. 1998, v. 249, p. 943-947.
  27. Stenger S., Hanson DA, Teitelbaum R et al. An antimicrobial activity of cytolyticT cells mediated by granulysin. Science. 1998,v.282,p. 121-125
  28. Ong P.Y., Ohtake T., Brandt C. et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Eng J. Med. 2002, okt 10; v. 347 (15), p. 1151-1160.
  29. Howell M.D. Boguniewicz M., Pastore S. etal. Mechanizm of hBD-3 deficiency in atopic dermatitis. J. Clinical Immunology. 2006, v. 121, p. 332-338.
  30. Елисютина О.Г. Обоснование специфической иммунотерапии больных атопическим дерматитом, осложненным рецидивирующей пиодермией. Диссертация канд. мед. наук. М., 2006.
  31. Bodo Mefnik. Disturbances of antimicrobial lipids in atopic dermatitis. JDDG. 2006, No. 4, p. 114-123
  32. Хамаганова И.В. Гнойничковые заболевания кожи. Леч. врач. 2006, №9, стр. 5-12.
  33. Сетдикова Н.Х., Латышева T.B. Комплексные механизмы развития хронического рецидивирующего фурункулеза и пути их коррекции. Иммунология. 2000, № 3, с. 48-50.
  34. Catherine M.T. Chronnell, Lucy R. Ghali, Rozina S. Ali et al. Human p Defensin-1 and -2 Expression in Human Pilosebaceous Units: Upregulation in Acne Vulgaris Lesions. Journal of Investigative Dermatology. 2001, v. 117, p. 1120-1125.
  35. Yamasaki K., Gallo R. L. Antimicrobial peptides in human skin disease. Eur J. Dermatol. 2008, v. 18 (1), p. 11-21.

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