Histafen antihistaminic and sedative effects in patients with chronic recurrent urticaria

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


The purposes of the study. The primary purpose was to show antihistaminic efficiency of Histafen in a daily doze of 150 mg per os within 14 days at patients with chronic urticaria (ChU) on an example of suppression of the skin reaction caused by histamin. The secondary purposes: To estimate a condition of microcirculation in the skin of patients with ChU during Histafen treatment and to confirm safety and absence of sedative effect of Histafen. Materials and methods of study. There were 20 adult patients (men and women) in the age from 18 to 55, with exacerbation of ChU included in the study; 20 healthy persons - as a control group. We made clinic and laboratory examination to all patients, including skin pricktitration with histamin, research of local microcirculation in a skin. Sedative effect estimated on the change of stability of attention by means of B. Burdon's proof test and volume of attention by Shulte tables.
Results. Histafen suppression of the skin urticaria and hyperemia which was caused by histamine in ChU patients was established: for 50% and 40% respectively. However these results are statistically doubtful - p=0,27 and p=0,18 respectively. The revealed changes of local microcirculation in the skin can testify to normalization of basal blood-groove parameters in skin of patients with ChU. Absence of sedative effect during of Histafen treatment was established: absence of statistically approved changes in parameters of volume of attention (p=0,6) and authentic improvement of stability of attention after the treatment (p=0,01) was noted. The conclusion. The study demonstrated high antihistaminic activity of Histafen, its safety and absence of sedative effect in patients with ChU.

About the authors

L V Luss

Institute of Immunology

Email: lusslv@yandex.ru
Institute of Immunology

E B Tuzlukova

Institute of Immunology

Institute of Immunology

E I Grebenchenko

Institute of Immunology

Institute of Immunology

References

  1. Клинические рекомендации. Аллергология. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2006, 240 с.
  2. Аллергология и иммунология: национальное руководство. Под ред. P.M. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, 656 с.
  3. Руководство для практикующих врачей «Рациональная фармакотерапия аллергических заболеваний». Под ред. P.M. Хаитова, Н.И. Ильиной, Т.В. Латышевой, Л.В. Лусс, М., «Литтерра». 2007, 504 с.
  4. Тузлукова Е.Б. Средства для лечения и профилактики аллергии. Рос. Аллергол. Журн. 2007, приложение, 28 с.
  5. Елисютина О.Т., Феденко Е.С., Федоскова Т.Е и соавт. Опыт применения сехифенадина (гистафена) в комплексной терапии атопического дерматита и хронической рецидивирующей крапивницы. Рос. Аллергол. Журн. М., 2004, №3, с. 87-91.
  6. Горбов Ф.Д. О «помехоустойчивости» оператора, в кн. Инженерная психология. М., «Изд-во МГУ». 1964, с. 340-357.
  7. Горбов Ф.Д., Мясников В.М. Психологические исследования. В кн. Первые космические полеты человека. М., «Наука». 1962, с. 73-81.

Statistics

Views

Abstract - 15

PDF (Russian) - 0

PlumX

Article Metrics

Metrics Loading ...

Dimensions


Copyright (c) 2009 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies