Vol 8, No 4 (2011)

in the review modern data on drug-induced pulmonary eosinophilia - heterogeneous group of the diseases proceeding separately (syndrome lÖffler, acute and chronic eosinophilic pneumonias), or as the component part of a DRESS-syndrome (drug reaction with eosinophilia and systemic symptoms) is introduced. The list of the medical products most often causing development of pulmonary eosinophilia is presented. clinical features of simple pulmonary eosinophilia, acute and chronic eosinophilia pneumonias, a DRESS-syndrome are described. Diagnostic criteria and principles of therapy of pulmonary eosinophilia depending on a clinical variant are reviewed.

Background. Clinical effectiveness estimation of efferent methods in complex treatment of Atopic Dermatitis. Method. the clinical effectiveness of intravenous laser blood radiation treatment (ivlBR), intravenous ultraviolet blood radiation treatment (ivUvBR) and extracorporal immunopharmacotherapy (eipt) was estimated in 198 patients with different clinical types of Atopic Dermatitis. Group of control included patients with standard basic therapy. Results. in patients with Atopic Dermatitis who had complex treatment ivlBR, ivUvBR, eipt was more rapid regression of inflammatory skin process and dynamic of index SCORAD were more rapid. this leaded to saving therapy time and reduction of relapses. Conclusion. the best effectiveness in treatment of Atopic Dermatitis complicated by secondary infection has ivUvBR or eipt with diuciphonum; in treatment of non-complicated of Atopic Dermatitis has ivlBR or eipt with dexametason.

Background. Allergic diagnosis is based on accurate clinical history and conducting of skin prick tests (sPt) and specific IgE determination. the past decade recombinant allergen components from pollen of birch are available for allergen-specific IgE antibody testing. the major allergen of birch tree pollen is Bet v 1; Bet v 2 is a well described minor allergen. Methods. 83 patients with birch pollinosis (55 male/28 female, age 4-35 years, mean 15,5) were observed. specific IgE levels were determined by using the ImmunoCap (Phadia, sweden); skin prick tests with standard aeroallergens panel was used. Results. All 83 patients had positive skin tests to birch pollen. the levels of specific IgE to rBet v1 had 87,9% of patients, sIgE to rBet v 2 (profilin) 14,5% of patients, sIgE to rBet v 1 and rBet v 2 13,3% of patients. Conclusion. the prevalence of the patients with presence of IgE - antibodies to profiling Bet v2 among citizens of moscow region, sensitized to birch, accounts 14,5%.

Background. To establish the clinical and immunological features of the manifestations of allergic diseases in children with IgE-mediated sensitization to potato. Methods. allergy tests (skin prick tests and / or the determination of specific IgE in serum by ImmunoCap, Phadia was performed in 171 children with allergic diseases, who had sensitization to food plant proteins. Results. sensitization to the potato found in 134 children. significant discrepancies (36%) in the results of in vitro and in vivo tests to the potatoes were shown. sensitization to the potatoes is more common in patients with atopic dermatitis (ad), especially in severe disease. among children with the level of specific IgE antibodies to potato ≥2 kUa / l there were more common patients with severe ad. the correlation between the level of specific IgE antibodies to the potatoes and some of food plant proteins was found. the relationship between the concentration of specific IgE to the potatoes and Bet v 2 was not detected. Conclusion. the presence and concentration of specific IgE to the potatoes to a certain extent associated with clinical manifestations of ad. the data obtained substantiate the determination of specific IgE antibodies to potato in children with ad, especially in severe cases.

Цель. проведение клинико-иммунологической оценки эффективности диетотерапии матерей в составе комплексной терапии атопического дерматита (атд) у их детей, находящихся на естественном вскармливании. Материалы и методы. наблюдали 100 детей раннего возраста с атд, находящихся на естественном вскармливании. 43 пациента с атд, матери которых получали элиминационную диету с заменой коровьего молока на козье молоко «амалтея», составили первую группу. во вторую группу вошли 57 детей с атопическим дерматитом, чьи матери получали элиминационную диету с заменой коровьего молока на козье «амалтея», составили первую группу. во вторую группу вошли 57 детей с атд, матери которых получали элиминационную диету с исключением всех видов молока. Результаты. на фоне проведенного лечения, которое включало диетотерапию кормящих матерей и противоаллергическое лечение их детей, у 94% пациентов была получена ремиссия атд. диетотерапия, проводимая у кормящих матерей, оказывала положительное влияние на снижение в их грудном молоке общего IgE и аллергенспецифических IgE и IgG к белкам коровьего и козьего молока. положительная динамика в сторону снижения концентрации в крови общего IgE, аллергенспецифических IgE и IgG к белку коровьего молока и его фракциям, а также к белку сои и козьего молока отмечалась у всех детей, независимо от вида диетотерапии кормящих матерей. Комплексная терапия способствовала у больных обеих групп уменьшению концентрации провоспалительных цитокинов в крови. Заключение. полученные данные подтверждают целесообразность проведения диетологических мероприятий у кормящих матерей, имеющих детей с атд, особенно если атд вызван белками коровьего молока.