Detection of IgE-antibodies to recombinant birch allergens rBet v 1 and rBet v 2 in patients withsensitization to birch pollen



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Abstract

Background. Allergic diagnosis is based on accurate clinical history and conducting of skin prick tests (sPt)
and specific IgE determination. the past decade recombinant allergen components from pollen of birch are
available for allergen-specific IgE antibody testing. the major allergen of birch tree pollen is Bet v 1; Bet v 2 is a
well described minor allergen.
Methods. 83 patients with birch pollinosis (55 male/28 female, age 4-35 years, mean 15,5) were observed. specific
IgE levels were determined by using the ImmunoCap (Phadia, sweden); skin prick tests with standard aeroallergens
panel was used.
Results. All 83 patients had positive skin tests to birch pollen. the levels of specific IgE to rBet v1 had 87,9% of
patients, sIgE to rBet v 2 (profilin) 14,5% of patients, sIgE to rBet v 1 and rBet v 2 13,3% of patients.
Conclusion. the prevalence of the patients with presence of IgE - antibodies to profiling Bet v2 among citizens
of moscow region, sensitized to birch, accounts 14,5%.

About the authors

M A Mokronosova

Email: mmokronosova@mail.ru

A V Sergeev

E S Korovkina

N G Konyukova

M A Mokronosova

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

A V Sergeev

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

E S Korovkina

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

I. Mechnikov Research Institute for Vaccines and Sera, RAMS

N G Konjucova

Moscow Research Institute of Pediatric and Child Surgery

Moscow Research Institute of Pediatric and Child Surgery

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