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Vol 10, No 5 (2013)

Articles
MODERN VIEW ON THE PROBLEM OF HOUSE DUST MITES SENSITIZATION
Kurbacheva O.M., Pavlova K.S., Melnikova E.A.
Abstract
Dermatophagoides pteronissinus, Dermatophagoides farinea and their products of vital activity are the main allergenic components of house dust. The only pathogenetic and effective method of treatment of patients with house dust mites induced allergic rhinitis and atopic bronchial asthma according to positions of evidencebased medicine is allergenspecific immunotherapy (ASIT) with house dust mites (Dermatophagoides pteronissinus, Dermatophagoides farinea) allergens. Modern data on prevalence of a sensitization to house dust mites at patients with respiratory manifestations of allergy are presented in the review, questions of carrying out ASIT by various methods with application of the standardized allergens, its efficiency and safety are discussed.
Russian Journal of Allergy. 2013;10(5):3-12
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LOCAL AND SYSTEMIC IMMUNE PARAMETERS IN SEVERE ATOPIC DERMATITIS AND CUTANEOUS T-CELL LYMPHOMA PATIENTS
Niyazov D.D., Fedenko E.S., Boldyreva M.N., Trofimov D.Y.
Abstract
Background.. To investigate expression of cytokines genes parameters in skin and blood in severe atopic dermatitis (AD) and cutaneous T-cell lymphoma (CTCL) patients comparing with healthy donors. Materials and methods. 20 severe AD patients, 20 CTCL patients and 20 healthy donors were included in the study. Skin samples and peripheral blood were used as material for immunological study. Interleukins — (IL)1B, IL2, IL2r, IL4, IL5, IL6, IL7, IL8, IL10, IL12A, IL12B, IL15 (total), IL15 , IL17A, IL18, IL23, IL28, IL29, Interferon γ (IFNγ), tumor necrosis factor α (TNFα), transforming growth factor beta 1 (TGFB1), forkhead box P3 (FOXP3) gene expression was defined in the skin and peripheral blood of severe AD patients, CTCL patients and healthy donors by real-time reverse transcription polymerase chain reaction (RT-PCR). Results. Statistically significant increase of cytokines genes IL4,IL12B,IL17A, TNFα in peripheral blood of severe AD patients compared with CTCL patients was marked. Studying of skin samples from CTCL patients has shown statistically significant increase of cytokines IL8, IL10, IL15, IFNγ genes expression and decrease of IL18 gene expression in comparison with skin samples from severe AD patients. Conclusion. Obtained cytokines genes expression cytokines genes parameters in peripheral blood of severe AD and CTCL patients had a certain similarities consisting of increased IL8, IFNγ and decreased IL6, IL23 genes expression in comparison with healthy donors. Substantial differences in peripheral blood of patients in comparison with healthy donors: increased IL-5, IL-12B genes expression in AD patients and decreased IL-8, IL-12A genes expression in CTCL patients, at the same time increased expression of IL-6, IL-8, IL-10, IFNγ genes in severe AD and CTCL patients were shown.
Russian Journal of Allergy. 2013;10(5):13-21
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FOOD ANAPHYLAXIS IN CHILDREN: RETROSPECTIVE ANALYSIS OF 53 CASES
Esakova N.V., Pampura A.N.
Abstract
Introduction. There are no studies on anaphylaxis in children in Russian Federation therefore this problem is a topical issue. Background. To determine the etiology, natural course of food anaphylaxis in Russian Federation children, to analyse the therapeutic care of anaphylaxis. Methods. 53 patients with food anaphylaxis were included in the study. All patients completed a questionnaire included questions about the triggers, clinical manifestations and treatment of anaphylaxis. Results. In 94% episodes of anaphylactic reactions occurred at home, 2/3 (66%) of patients had two or more episodes of food anaphylaxis before, 5 (8%) infants didn’t have allergic diseases, 23 patients (43%) had anaphylactic reactions to more than one product. Cow’s milk (43%) was the most common cause of anaphylaxis. Cow’s milk caused anaphylaxis in 67% of children under 2 years (p<0,0001). In 98% of patients target organs of anaphylactic reacnions were skin / mucous and in 87% — respiratory system. In the group of children over 2 years old cardiovascular symptoms were more often (p<0,00l5). In the majority of patients delayed diagnosis of anaphylaxis more than 4 years was estimaited. Only 7% of children had the injection of adrenaline during anaphylactic reactions. Conclusion. The results of the study showed the lack of experience in investigation of anaphylaxis in the Russian Federation, which consequently leads to incorrect diagnosis and not effective treatment.
Russian Journal of Allergy. 2013;10(5):22-26
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DRUG ALLERGY. RECOMMENDATIONS FOR CLINICIANS (PART 1)
Ilina N.I., Latisheva T.V., Miasnikova T.N., Luss L.V., Kurbacheva O.M., Erokhina S.M.
Abstract
Recommendations contain modern data about incidence, etiology, patogenesis, diagnostics and treatment of drug allergy.
Russian Journal of Allergy. 2013;10(5):27-40
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NETHERTON SYNDROME
Revyakina V.A., Timofeeva A.M., Monosova O.Y., Kuvshinova E.D.
Abstract
The article presents the clinical case of the rare genetic disease Netherton syndrome occurring under the guise of various diseases, including allergies. the etiology of this disease is unknown diagnostics is complicated.
Russian Journal of Allergy. 2013;10(5):41-45
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TARGET THERAPY OF BRONCHIAL ASTHMA WITH LEUKOTRIENE RECEPTOR AGONISTS
Nenasheva N.M.
Abstract
This article describes the features of asthma phenotypes such as asthma in smokers and asthma and obesity. The role of cysteinyl leukotrienes is discussed in the formation of inflammation in these phenotypes of asthma. The leukotriene receptor antagonists, including montelukast are effective in therapy of this category of patients.
Russian Journal of Allergy. 2013;10(5):46-54
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ASSESSMENT OF CLINICAL-IMMUNOLOGICAL EFFECTIVENESS OF COMPLEX THERAPY OF INFANT ATOPIC DERMATITIS
Denisova S.N., Sentsova T.B., Belitskaya M.Y.
Abstract
The work is aimed at assessment of clinicalimmunological effectiveness of diet therapy based on hypoallergenic formula used for infants with atopic dermatitis. 167 infants with atopic dermatitis associated with cow’s milk protein allergy have been put included under outpatient observation. 52 infants of from the first group were being fed on whole goat milk’s formula, 56 infants of from the the second group — cows’ milk protein hydrolysate and 59 infants of the from the third groupsoy’s isolate formula. The age of infants was 2, 5—9 months. The duration of observation was 3—12 months. Complex therapy has been conducted over the infants and it contained antiallergenic treatment and diet therapy with hypoallergenic baby formula. The majority of patients showed improvement due to applied treatment. The first group’s infants with positive clinical dynamic showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH and soy’s protein. The infants of the second and third groups also showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH, soy’s protein and goat’s milk at clinical remission. All the infants with positive clinical effect showed trend to decrease of IL12, IL13, sICAM1 and sEselectin’s concentration in the blood stream, that can indicate on leukocyte adherence inhibition and cell migration to the area of inflammation. Based on the results of research, we can conclude that replacement of one product with another one by taking into account their clinicalimmunological effectiveness as the method of treatment the of atopic dermatitis patients let us optimize infant diet therapy.
Russian Journal of Allergy. 2013;10(5):55-60
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FAMCICLOVIR IN THERAPY OF ATOPIC DERMATITIS PATIENTS WITH HERPES SIMPLEX INFECTION
Zuikova I.N., Shulzhenko A.E., Fedenko E.S., Elisutina O.G.
Abstract
The prevalence of herpes simplex virus in different age groups, the high frequency of relapsing forms of infection, torpid course, postherpetic complications are relevant medical and social problems. Often, practitioners create significant difficulties in establishing the diagnosis, choice of strategy in patients with herpes simplex. The paper presents the methods of diagnosis of herpes simplex and their application in atopic dermatitis patients, issues of acyclic nucleoside therapy (acyclovir, famciclovir) in different clinical forms of herpes simplex with individual approach to the selection of an antiviral drug and patterns of use.
Russian Journal of Allergy. 2013;10(5):61-69
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DIET THERAPY IN CHILDREN WITH FOOD ALLERGY
Varlamov E.E., Pampura A.N.
Abstract
Introduction. Experience of amino acid formulas application in eldest children is limited. Background. To estimate efficiency of amino acid formula at children at the age from 1 till 10 years with atopic dermatitis (AD). Methods. 9 AD children with multiple food allergy were included in the study. All patients took amino acid formula «Neocate Advance». The efficiency of diet therapy was estimated with index SCORAD. Results. The average value of index SCORAD decreased AFTER 1 week therapy, Me — 48,5 [44,5; 52,5] to Me — 18,8 [18; 37,5] a point (p=0,008), after 2 weeks — Me — 12,6 [7,8; 13,5] a point (p=0,008). Conclusion. Medical amino acid formula «Neocate Advance» is an effective diet therapy of AD children with multiple food allergy.
Russian Journal of Allergy. 2013;10(5):70-75
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INFORMATIONAL LETTER
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Russian Journal of Allergy. 2013;10(5):76-78
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CONGRESSES, CONFERENCES
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Russian Journal of Allergy. 2013;10(5):79-79
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ASTAFIEVA N.G. ANNIVERSARY
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Russian Journal of Allergy. 2013;10(5):80-81
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GUSHIN I.S. 75 th ANNIVERSARY
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Russian Journal of Allergy. 2013;10(5):82-83
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