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Vol 16, No 1 (2019)

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Restricted Access Access granted
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Articles
Editorial
Il'ina N.I., Latysheva E.A.
Russian Journal of Allergy. 2019;16(1):5-6
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Academician Rakhim Musaevich Khaitov
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Russian Journal of Allergy. 2019;16(1):7-8
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An issue of selecting of immunobiological therapy of bronchial asthma
Ilina N.I.
Abstract
The results of indirect treatment comparison of the efficacy of anti-Il-5 pathway therapies in severe eosinophilic asthma on the basis of network meta-analysis and Cochrane review are presented in the article.
Russian Journal of Allergy. 2019;16(1):9-12
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The role of ß2-adrenergic receptor gene polymorphisms in the pharmacological response to bronchial asthma therapy
Pavlova K.S., Mdinaradze D.S., Kofiadi I.A., Kurbacheva O.M.
Abstract
This article represents an abstract and analytical review of studies devoted to the polymorphisms of β2-adrenergic receptor gene (ADRB2) and their associations with the degree of severity of bronchial asthma (BA) and response to standard pharmacotherapy. The results of the analysis showed a high heterogeneity of the data obtained, which is aggravated by different goals, objectives and study design. If the polymorphism of ADRB2 gene affects the expression of this receptor, it is possible that these asthma patients will show a low response to SABA / LABA; short- and long-acting anticholinergics will be preferred as bronchodilators. It is impossible to make a unique conclusion about the association between the polymorphisms of ADRB2 gene and the SABA / LABA responsiveness according to the results of analyzed publications. Data of the prevalence of homozygous alleles and studied associations among different populations are contradictory. Achievement of the asthma symptoms control is the main goal of asthma therapy. At the same time it’s impossible for a limited number of asthma patients in spite of the provision of current effective pharmacological resources. These aspects necessitate the research of the molecular-genetic mechanisms of pathogenesis in order to improve diagnostics and individual approach to the pharmacotherapy choice for patients with poor asthma control.
Russian Journal of Allergy. 2019;16(1):13-22
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Some features of the prevalence of respiratory allergy in southern Russia
Macharadze D.S.
Abstract
The review article presents data on the prevalence of respiratory allergy - allergic rhinitis and bronchial asthma in southern Russia, published over the past decades. The dominant role of pollen allergy is shown in almost the entire southern region of Russia. In the Chechen Republic, sensitization to house dust mites and grass pollen was found in patients with respiratory allergy equally (51.1 and 52.5%, respectively), whereas ragweed and mugwort sensitization was 3 times less (26.6 and 20.7%, respectively) compared with the neighboring regions of southern Russia. These data demonstrate climate-geographical, environmental and other regional features in the prevalence of respiratory allergies.
Russian Journal of Allergy. 2019;16(1):23-28
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The clinical significance of food animal allergens
Pampura A.N., Varlamov E.E.
Abstract
Animal foods products contain the most balanced complex of essential nutrients. The clinical manifestations of allergy to these products are varied. Key aspect of this problem is diagnostics and assessment of cross-reactivity. The food animal products that more often induce symptoms include cow’s milk, hen’s egg, fish, mollusks, crustaceans, mammalian meat. Data on the main classes of food animal allergens inducing the development of cross-allergic reactions as well as syndromes associated with cross-reactivity like «bird-egg», «cat-pork», «fish-chicken» and a-Gal-syndrome/«red meat syndrome» are described in this article.
Russian Journal of Allergy. 2019;16(1):29-35
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The five year monitoring of the air environment in Samara
Manzhos M.V., Khabibulina L.R., Vlasova N.V., Kavelenova L.M., Mazokha K.S., Zhukova N.N., Aseeva E.V., Kozlova O.S., Moiseeva T.V.
Abstract
Aim. To determine the regional characteristics of the pollen spectrum of the air environment by the end of the five-year monitoring; to create the pollen calendar of allergenic plants in Samara, Russia. Materials and methods. Pollen was sampled using the volumetric method with a self-engineered pollen impactor into glass slides, covered with a mixture of petrolatum and wax. The pollen grains were counted and classified according to the systematic groups. Results. IIn 2013 the Samara urban air basin contained pollen of 21 taxa (12 woody taxa and 9 herbaceous taxa); in 2014 - 20 taxa (13 woody and 7 herbaceous); in 2015 - 20 taxa (12 woody and 8 herbaceous); in 2016 - 21 taxa (13 woody and 8 herbaceous); in 2017 - 18 taxa (10 woody and 8 herbaceous). During the five-year survey the dominant taxa were ragweed (24.3%), poplar (12,0%), birch (11.5%), pine (7.5%), maple (6.3%), elm (6.3%), nettle (5.8%), willow (4.8%), Gramineae (4.7%), and wormwood (3.7%). 10 dominant taxa were determined, which formed from 90% to 95% of the annual pollen volume. The prevailing taxa varied considerably from year to year by specific weight. Only three pollen species were present in the spectrum annually in the amount of more than 4% of the annual amount: poplar, birch and ambrosia pollen grains. Conclusion. Regional features of aeropalynological situation was revealed and pollen calendar of allergenic plants in Samara was created.
Russian Journal of Allergy. 2019;16(1):36-44
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IgE and IgG4-autoantibodies in patients with bronchial asthma
Gervazieva V.B., Konishcheva A.Y., Samoilikov P.V., Magarshak O.O., Mazurina S.A., Sveranovskaya V.V.
Abstract
The aim. Special interest has been recently noted in the autoreactivity as one of the mechanisms of bronchial asthma (BA) pathogenesis. The purpose of the study was to determine levels of IgE- and IgG4-autoantibodies (autoAbs) to tissue antigens (Ag) - keratin, collagen III and VI types, myosin and elastin using adapted ELISA method in blood serum of 88 patients with bronchial asthma (BA) of different severity and clinical course. Results. We determined that in patients with BA the quantitative levels and frequency of Ig-EautoAbs to all those Ags were significantly enhanced and were more prominent in severe (59-81%) than in mild and moderate BA (p<0.05) and were decreased during BA exacerbation. We also found increased frequency of detection and higher levels of IgE-Abs in long-term disease natural course (more than 5 years). The levels of IgG4-Abs to all listed Ags in patients with asthma was also enhanced compared with healthy people, but its levels oppositely decreased as the disease severity worsened. The frequency of elevated IgG4-autoAbs had higher prevalence among patients with mild BA. Direct correlation between the IgG-4autoAbs and IL-10 in the serum of patients with BA mild and moderate severity was indicated. Conclusions. IgE-autoAbs, when detected in patients with asthma, reflect the degree of lung tissue alterations and correlate with the disease severity, while IgG4-autoAT could indicate the functional activity of immune regulatory mechanisms.
Russian Journal of Allergy. 2019;16(1):45-52
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Effect of hypovitaminosis D on the activity of chronic spontaneous urticaria
Vitchuk A.V., Kovrigina N.V., Aksenova S.A., Slabkaya E.V., Volkova E.V., Bityutskaya V.V., Meshkova R.Y.
Abstract
The aim of the study. To study the effect of hypovitaminosis D on the activity of CSU and the clinical efficacy of cholecalciferol in the complex therapy of patients with different baseline level of vitamin D metabolites. Methods. 48 CSU patients were included in the study - 20 patients in the main group, 28 in the comparison group. The control group consisted of 26 healthy donors. Patients with CSU of the main group regardless of the initial level of vitamin D were treated with non sedative antihistamines and an aqueous solution of cholecalciferol (vitamin D3) at the dosage of 10,000 units/day. The course of treatment with cholecalciferol was 4 weeks. The concentration of 25(OH)D and 1,25(OH)2D was determined in the blood serum of patients before and after the treatment and in control group. The diagnosis of hypovitaminosis D was carried out on the basis of 25(OH)D concentrations <30 ng/ml. The activity of CSU was assessed by the indicators of the urticaria activity score UAS-7. Results. Hypovitaminosis D occurs with the same frequency in patients with CSU and in control group. At the same time, the activity of CSU in patients with hypovitaminosis D is significantly higher than in patients with normal vitamin D levels, as evidenced by UAS-7 (respectively 24.3±13.68 and 17.5±8.1; p<0.05). A negative correlation was found between the activity of CSU and the concentration of 25(OH)D in patients with hypovitaminosis D. Correction of hypovitaminosis D with an aqueous solution of cholecalciferol at a dosage of 10,000 units/day during 4 weeks with simultaneous basic therapy with non sedative antihistamines leaded to a reliable decrease of UAS-7, however, complete control of the disease did not occured. In patients with an initially normal level of 25(OH)D, an additional administration of vitamin D therapy does not lead to significant changes of UAS-7. The concentration of 1,25(OH)2D in the blood serum of patients with CSU did not depend on the presence or absence of hypovitaminosis D and did not change on cholecalciferol therapy.
Russian Journal of Allergy. 2019;16(1):53-58
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Role of skin microbiome in epidermal barrier dysfunction and development of atopic dermatitis in high risk infants
Migacheva N.B.
Abstract
Background. Colonization of skin with S. aureus in atopic dermatitis (AD) patients is a widespread phenomenon and a factor complicating the course of the disease. At present, it is not quite clear the role of S. aureus in the development of AD in children at risk. The aim of our study was to discribe the skin microbiome composition in young children at risk, as well as to investigate the role of S. aureus in skin barrier dysfunction and the development of AD. Material and methods. 12months follow-up study of 37 infants at risk has been performed. It included a general clinical examination, a microbiological investigation of skin microbiome (at 1 and 6 months), and investigation of epidermal barrier function by determining the transepidermal water loss (TEWL) at 1, 3, 6 and 12 months. Realization of AD during the observation period was considered as main outcome. Results. The prevalence of S. aureus colonization of infants aged 1 month was 45.9%, at the age of 6 months - 29.7%. Correlation analysis revealed an association between the skin colonization with S. aureus and a decrease of TEWL (p = 0.004), as well as the cumulative incidence of AD (p <0.001). Conclusion. The detection of S. aureus as a part of skin microbiocenosis in AD infants at risk is associated with dysfunction of the epidermal barrier and is a significant risk factor for the AD development.
Russian Journal of Allergy. 2019;16(1):59-64
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Current aspects of pimecrolimus application in clinical practice
Lvov A.N.
Abstract
Modern aspects of patogenetic conception of neurogenic inflammation in immune associated dermatoses are presented in the article. On the basis of literature data and own experience important aspects of pimecrolimus application in atopic dermatitis and other dermatoses are reviewed.
Russian Journal of Allergy. 2019;16(1):65-70
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Anti-IgE therapy for severe atopic asthma
Knyazheskaya N.P., Belevskiy A.S., Safoshkina E.V.
Abstract
The first targeted drug that is used for patients with uncontrolled moderate and severe atopic asthma (BA) was anti-IgE drug omalizumab (Xolar®). This drug is prescribed to patients with moderate to severe atopic BA, which is not controlled by baseline therapy corresponding to stage 4 (level of evidence A). Clinical studies have convincingly demonstrated that in patients with severe asthma requiring treatment with high doses of inhaled corticosteroids or oral glucocorticosteroids, treatment with Xolar® reduces the frequency of exacerbations of BA, reduces the severity of asthma and allows for steroid-dependent BA to cancel or significantly reduce the dose of systemic corticosteroids. In addition, the anti-inflammatory effect of the drug has been proven. Studies in recent years provide more and more data on the positive impact of omalizumab on the remodeling of the respiratory tract.
Russian Journal of Allergy. 2019;16(1):71-78
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The efficacy and safety of antihistamine therapy in school-age children
Sidorovich O.I.
Abstract
Every year the prevalence of allergic diseases is steadily increasing. Histamine is the main mediator of allergic inflammation. Cetirizine is an effective, selective H1-receptor blocker, and drug of choice in complex treatment of various allergies among adults as well as children.
Russian Journal of Allergy. 2019;16(1):79-84
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New opportunities for the combined therapy of allergic rhinitis in real clinical practice
Nazarova E.V.
Abstract
This paper assesses the efficacy of the original combined medication Allergoferon® beta (betamethasone + interferon alpha-2b) in real clinical practice among patients with seasonal allergic rhinitis (AR). The research program results demonstrated a good efficacy of the given medication: there were a decrease in nasal congestion as well as restoration of nasal breathing and in patients with concomitant allergic conjunctivitis - a reduction in the severity of eye symptoms. A low incidence of side effects was observed. It was shown that Allergoferon® beta can be recommended as monotherapy for patients with mild and moderate AR and in complex therapy for patients with severe AR.
Russian Journal of Allergy. 2019;16(1):85-89
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Congresses, conferences
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Russian Journal of Allergy. 2019;16(1):90-92
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Babakhin Alexandr Aleksandrovich (20.08.1946 - 24.01.2019)
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Russian Journal of Allergy. 2019;16(1):93-93
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Alekseev Leonid Petrovich (04.06.1939 - 29.01.2019)
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Russian Journal of Allergy. 2019;16(1):94-94
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