Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media3410.36691/RJA34Research ArticleNew opportunities for the combined therapy of allergic rhinitis in real clinical practiceNazarovaE VEv.nazarova@nrcii.ruNRC Institute of Immunology FMBA ofRussia15022019161858910032020Copyright © 2019, Pharmarus Print Media2019This paper assesses the efficacy of the original combined medication Allergoferon® beta (betamethasone + interferon alpha-2b) in real clinical practice among patients with seasonal allergic rhinitis (AR). The research program results demonstrated a good efficacy of the given medication: there were a decrease in nasal congestion as well as restoration of nasal breathing and in patients with concomitant allergic conjunctivitis - a reduction in the severity of eye symptoms. A low incidence of side effects was observed. It was shown that Allergoferon® beta can be recommended as monotherapy for patients with mild and moderate AR and in complex therapy for patients with severe AR.allergic rhinitisnasal glucocorticoidsbetamethasoneinterferon alpha-2bAllergoferon betaаллергический риниттопические назальные глюкокортикостероидыбетаметазонинтерферон альфа-2bАллергоферон бета[Гущин ИС, Ильина НИ, Польнер С.А. Аллергический ринит: Пособие для врачей. ГНЦ «Институт иммунологии», РААКИ. М., 2002][Allergic Rhinitis and its Impact on Asthma (ARIA) guide-lines-2016 revision; https://wwwjacionline.org/article/S0091-6749(17)30919-3/abstract.][Bousquet J., Khaltaev N., Cruz AA. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;(63):8-160.][Leynaert B., Bousquet J., Neukirch C. Perennial rhinitis: an independent risk factor for asthma in nonatopic subjects: results from the European Community Respiratory Health Survey. J. Allergy Clin Immunol. 1999;(104):301-304.][Gergen PJ, Turkeltaub PC. The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II). J. Allergy Clin Immunol. 1992;(90):579-588.][Pedersen PA, Weeke ER. Asthma and allergic rhinitis in the same patients.Allergy. 1983;(38):25-29.][Greisner WA, Settipane RJ, Settipane GA. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc. 1998;(19):185-188.][Guerra S., Sherrill DL, Baldacci S. Rhinitis is an independent risk factor for developing cough apart from colds among adults. Allergy. 2005;(60):343-349.][Sami AM, Ahmed N., Ahmed S. The effect of novel combination therapy with azelastine hydrochloride and fluticasone propionate in allergic rhinitis. Otolaryngol. (Sunnyvale.) 2016;(6):ID261.][Лопатин АС, Гущин ИС, Емельянов А.В. Клинические рекомендации по диагностике и лечению аллергического ринита. Consilium medicum. 2001;9:33-44][Международный консенсус в лечении аллергического ринита (Версия Европейской академии аллергологии и клинической иммунологии, 2000). Российская Ринология. 2000;3:5-30][Хаитов РМ, Ильина НИ, Латышева Т.В. Рациональная фармакотерапия аллергических заболеваний. М., 2007:502]