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Vol 6, No 1 (2009)

Articles
Editorial
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Russian Journal of Allergy. 2009;6(1):3-4
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Andrey Dmitrievitch Ado: 100 th Birthday Anniversary
Gushchin I.S., Ado M.A., Gushchin I.S., Ado M.S.
Russian Journal of Allergy. 2009;6(1):5-9
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Creation of the allergovaccines on the base of new technologies
Fedoseeva V.N., Fedoseeva V.N.
Abstract
The achievements of molecular immunology and allergology at the last years allow to create new hypoallergenic and effective allergovaccines for ASIT. The structure of leading allergen epitopes responsible for cross-reactivity in allergic process was decoded. It was shown, that allergen cross-reactivity appears to be all-biological phenomenon that creates the certain difficulties in the development of AV specific preparations. Recombinant allergens play the important role in standardization of diagnostic and medical forms of allergens and allow to get comparable results on IgE-linking activities of natural and recombinant forms in the skin and in vitro-tests. Usage of new technologies in creation of AV for ASIT is perspective. Recombinant allergens define a new strategy in the development of allergen-specific therapy. The prospects of new technologies using the development of AV with high effectiveness in treatment of patients with allergic diseases, is justified and will allow to get the safe medical preparations, which action is directed on creation of antiallergic immune response.
Russian Journal of Allergy. 2009;6(1):10-17
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Chitin and chitinases in allergic reactions
Kulikov S.N., Tyurin Y.A., Dolbin D.A., Fassakhov R.S., Kulikov S.N., Turin I.A., Dolbin D.A., Fassakhov R.S.
Abstract
Chitin - the structural component of fungal cell wall, arthropodal exoskeleton, microfilarial sheat and egg of helminths. Allergens of this organisms cause allergic diseases. The potential role of chitin in allergic reactions has been discussed. Other studies have suggested that chitin preparations may skew immunity away from T-helper-2-mediated allergic responses. Chitinases, enzymes that can degrade chitin polymer, and chitinase-like proteins might also play an important role in allergic disease pathogenesis.
Russian Journal of Allergy. 2009;6(1):18-23
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Methodology of the inflammation level evaluation in nasalsecretions
Mokronosova M.A., Kochetova Y.I., Mokronosova M.A., Kochetova Y.I.
Abstract
The questions of local nasal inflammation typical for allergic and infectious rhinitis are discussed. These proteins appear in nasal cavity in the beginning of the disease earlier than in the blood. That's why it is necessary to collaborate new non - invasive methods of new markers diagnostics of local inflammation.
Russian Journal of Allergy. 2009;6(1):24-29
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Dendritic cells: perspectives of clinical application
Kremer E.E., Vasil'eva M.V., Ogorodova L.M., Kremer E.E., Vasilyeva M.V., Ogorodova L.M.
Abstract
In this review basic properties of dendritic cells and their role in immunopathological conditions are considered. Methods of dendritic cells cultivation and their influence on functional activity of dendritic cells are described. Perspectives of dendritic cells clinical application for immunotherapy of cancer, infection diseases, allergy and autoimmune diseases are analyzed.
Russian Journal of Allergy. 2009;6(1):30-38
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Influence of sublingual allergen-specific immunotherapy on dynamics of immunological parameters in patients with pollinosis
Manzhos M.V., Fedenko E.S., Myagkova M.A., Molotilov B.A., Shkadov S.A., Petrochenko S.N., Kiseleva R.Y., Manzhos M.V., Fedenko E.S., Myagkova M.A., Molotilov B.A., Shkadov S.A., Petrochenko S.N., Kiseleva R.Y.
Abstract
Background. To study the influence of sublingual allergen-specific immunotherapy (slASIT) on dynamics of immunologic parameters in patients with pollinosis. Materials and methods. 40 healthy persons and 25 pollinosis patients received slASIT course with mixt of autumn grasses allergen. IgA, IgM, IgG, IgE antibodies, slgA, albumin in saliva and IgA, IgM, IgG, IgE antibodies, total IgE, IFN-γ, IL-4 in serum were investigated. Results. Patients with pollinosis have infringements of both local and general immunity. SlASIT changes a profile of cytokines aside Th-1, stimulates formation of the secretory allergen-specific antibodies, reduces IgE antibodies in saliva. Conclusion. SlASIT is a highly effective method of allergic diseases treatment and it induces B-cellular and T-cellular tolerance.
Russian Journal of Allergy. 2009;6(1):39-44
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Allergen-specific immunotherapy with pollen allergoids in the treatment ofhay fever in children
Gayduk I.M., Makarova I.V., Trusova O.V., Breykin D.V., Sukhorukova V.G., Arakelyan R.N., Korostovtsev D.S., Gaiduk I.M., Makarova I.V., Trusova O.V., Breykin D.V., Sukhorukova V.G., Arakelyan R.N., Korostovtsev D.S.
Abstract
Background. The research of effective methods of allergen-specific immunotherapy (ASIT) with good tolerability is important in children with allergic disorders. The aim of the study was to investigate effectiveness and safety of ASIT with pollen allergoids for hay fever treatment in children. Methods. 71 patients 5 to 17 years old with diseases caused by tree pollen sensitization: allergic rhinoconjunctivitis in 36 patients, rhinitis combined with pollen asthma in 17, combined with atopic dermatitis in 1, and pollen asthma in 17, were included in the study. 2 courses of subcutaneous ASIT out of flowering season were conducted in every child using commercially available pollen allergoids. ASIT effectiveness was assessed using 4-point scale where 4 points represents complete disease remission, and 1 point represents lack of effectiveness. Local and systemic side effects were registered as parameters of ASIT safety. Results. Total dose of allergen was 13 768 PNU after the 1st course of ASIT, and 12 700 PNU after the 2nd course. Effectiveness of the 1st course of ASIT was 4,0 points out of 4,0 and of the 2nd course - 4,0 points. Local side effects (infiltration larger than 25 mm, itching and oedema in injection site) in 19,7% patients and systemic side effects (allergic rhinitis exacerbation, urticaria) in 11,3% patients were stopped after allergoid dose adjustment. Conclusion. ASIT with pollen allergoids is effective for hay fever treatment in children. Children with bronchi al asthma are at higher risk for adverse events and need individual dose adjustment.
Russian Journal of Allergy. 2009;6(1):45-50
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Urticaria and angioedema. Practical guide for practitioners. RUSSIAN POSITION PAPER (Part five)
Astaf'eva N.G., Borzova E.Y., Goryachkina L.A., Danilycheva I.V., Emel'yanov A.V., Kochergin N.G., Luss L.V., Meshkova R.Y., Monakhov K.N., Pampura A.N., Revyakina V.A., Sidorenko I.V., Smir nova G.I., Fedenko E.S., Tsyvkina G.I., Astafieva N.G., Borzova E.U., Gorjachkina L.A., Danilicheva I.V., Emelianov A.V., Kochergin N.G., Luss L.V., Meshkova R.J., Monakhov K.N., Pampura A.N., Revjakina V.A., Sidorenko I.V., Smirnova G.I., Fedenko E.S., Tsivkina G.I.
Russian Journal of Allergy. 2009;6(1):51-59
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Links between rhinitis and asthma: therapeutic significance of intranasal glucocorticosteroids
Goryachkina L.A., Nenasheva N.M., Goryachkina L.A., Nenasheva N.M.
Abstract
Medical and social importance of allergic rhinitis is due to: high prevalence among the population of adults and children in some countries, reaching 50% among adolescents, as well as its close links with diseases such as bronchial asthma, acute and chronic rhinosinusitis, allergic conjunctivitis. Currently, allergic rhinitis and bronchial asthma consider as one disease of the airways due to the presence of a cross-connection between the upper and lower respiratory airways and systemic response to the allergen. High efficiency of intranasal corticosteroids in treatment of allergic rhinitis determined by their pronounced anti-inflammatory action and effective influence on all phases of the pathogenesis of the disease. In addition, intranasal corticosteroids are effective in improving of ocular symptoms, fn particular, fluticasone propionate (Flixonase) causes a significant decrease in ocular symptoms caused by seasonal rinoconjunctivitis. Flixonase improves sleep and daytime fatigue and somnolence in patients with perennialallergic rhinitis.
Russian Journal of Allergy. 2009;6(1):60-66
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Efficacy of levocetirizine treatment in patients with chronic dermatoses
Kungurov N.V., Kokhan M.M., Grishaeva E.V., Keniksfest Y.V., Martsinkovskiy D.A., Kungurov N.V., Kokhan M.M., Grishaeva E.V., Keniksfest J.V., Marzinkowsky D.A.
Abstract
Представлен анализ опыта применения антигистаминного препарата Ксизал (левоцетиризин) в терапии хронических дерматозов. Определены параметры противозудного действия препарата, установлена высокая эффективность лечения больных хроническими дерматозами с использованием препарата Ксизал.
Russian Journal of Allergy. 2009;6(1):67-75
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Antihistamines in the treatment of allergic and pseudoallergic reactions
Luss L.V., Luss L.V.
Abstract
К основным медикаментам, воздействующим на симптомы аллергии и контролирующим течение аллергических заболеваний, относятся средства, которые ингибируют секрецию и высвобождение медиаторов аллергии, а также препараты, подавляющие воспалительные реакции. В обзоре представлены основные группы антигистаминных препаратов, используемых в клинической аллергологии и их основные характеристики, позволяющие дифференцированно подходить к назначению в комплексной терапии различных аллергических и псевдоаллергических реакций.
Russian Journal of Allergy. 2009;6(1):78-84
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Fluticasonepropionate (Nazarel) - new topical nasal corticosteroid
Il'ina N.I., Kozlov V.S., Pavlova K.S., Il'ina E.V., Latysheva E.A., Chechneva N.G., Iljina N.I., Kozlov V.S., Pavlova K.S., Iljina E.V., Latysheva E.A., Chechneva N.G.
Russian Journal of Allergy. 2009;6(1):85-89
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Congresses, Conferences
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Russian Journal of Allergy. 2009;6(1):90-91
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Instructions for Authors
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Russian Journal of Allergy. 2009;6(1):94-96
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