Links between rhinitis and asthma: therapeutic significance of intranasal glucocorticosteroids

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Abstract


Medical and social importance of allergic rhinitis is due to: high prevalence among the population of adults and children in some countries, reaching 50% among adolescents, as well as its close links with diseases such as bronchial asthma, acute and chronic rhinosinusitis, allergic conjunctivitis. Currently, allergic rhinitis and bronchial asthma consider as one disease of the airways due to the presence of a cross-connection between the upper and lower respiratory airways and systemic response to the allergen. High efficiency of intranasal corticosteroids in treatment of allergic rhinitis determined by their pronounced anti-inflammatory action and effective influence on all phases of the pathogenesis of the disease. In addition, intranasal corticosteroids are effective in improving of ocular symptoms, fn particular, fluticasone propionate (Flixonase) causes a significant decrease in ocular symptoms caused by seasonal rinoconjunctivitis. Flixonase improves sleep and daytime fatigue and somnolence in patients with perennialallergic rhinitis.

References

  1. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update. Allergy (Suppl.86). 2008, v. 63, p. 1-160.
  2. Ильина Н.И. Эпидемиология аллергического ринита. Рос. ринология. 1999, № 1, с. 23-24.
  3. Reed S.D., Lee T.A., McCrory D.C. The economic burden of allergic rhinitis: a critical evaluation of the literature. Pharmacoeconomics. 2004, v. 22, p. 345-361.
  4. Leynaert B., Neukirch F., Demoly P. et al. Epidemiologic evidence for asthma and rhinitis comorbidity. J. Allergy Clin. Immunol. 2000, v. 106, p. 201-205.
  5. Bousquet J., Cauwenberge P., Khaltaev N. Allergic rhinitis and its impact on asthma. J. Allergy Clin. Immunol. 2001, v. 108, (Suppl), p. 147-334.
  6. Астафьева Н.Г., Удовиченко Е.Н. Бронхиальная астма и аллергический ринит: фармакоэпидемиологический анализ сочетанной патологи. Рос. Аллергол. Журн. 2005, № 3, с. 45-49.
  7. Guerra S., Sherrill D.L. et al. Rhinitis as an independent risk factor for adult-onset asthma. J. Allergy Clin. Immunol. 2002, v. 10, p. 419-425.
  8. Togias A. Rhinitis and asthma:evidena for respiratory system integration. J. Allergy Clin. Immunol. 2003, v. 111, р. 1171-1183.
  9. Braunstahl G.-J., Fokkens W Nasal involvement in allergic asthma. Allergy. 2003, v. 58, p. 1235-1243.
  10. Corren J. Allergic rhinitis and astnma: how important is the link? J. Allergy Clin. Immunol. 1997, v. 99, p. 781-786.
  11. Sehmi R.,Baatjes AJ., Denburg JA. Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseases. Curr. Drug Targets Inflamm. Allergy. 2003, v. 2, p. 271-278.
  12. Braunstahl G.J., Hellings P.W. Nasobronchial interaction mechnisms in allergic airways disease. Curr Opin Otolaryngol Head Neck Surg. 2006, v. 14, p. 176-182.
  13. Braunstahl G.J., Kleinjan A., Overbeek S.E. et al. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am. J. Respir. Crit. Care Med. 2000, v. 161 (6), p. 2051-2057.
  14. Braunstahl G.J., Overbeek S.E., Kleinjan A. et al. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J. Allergy Clin. Immunol. 2001, v. 107 (3), p. 469-476.
  15. Welsh P.W., Stricker W.E., Chu-Pin C. et al. Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. Mayo Clin. Proc. 1987, v. 62 (2), p. 125-134.
  16. Corren J., Adinoff A.D., Buchmeier A.D. et al. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J. Allergy Clin. Immunol. 1992, v. 90 (2) p. 250-256.
  17. Henriksen J.M., Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am. Rev. Respir. Dis. 1984, v. 130 (6), p. 1014-1018.
  18. Watson W.T., Becker A.B., Simons F.E. Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness. J. Allergy Clin. Immunol. 1993, v. 91 (1 Pt 1), p. 97-101
  19. Taramarcaz P., Gibson P.G. The effectiveness of intranasal corticosteroids in combined allergic rhinitis and asthma syndrome. Clin. Exp. Allergy. 2004, v. 34, p. 1883-1889.
  20. Bernstein D.I., Levy AL. et al. Treatment with intranasal fluticasone propionate significantly improves ocular symptoms in patients with seasonal allergic rhinitis. Clin. Exp. Allergy. 2004, v. 34, p. 952-957.
  21. DeWester J., Philpot E.E. et al. The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis. Allergy Asthma Proc. 2003, v. 24, p. 331-337.
  22. Meltzer E.O., Rickard KA. et al. Onset of therapeutic effect of fluticasone propionate aqueous nasal spray. Ann. Allergy Asthma Immunol. 2001, v. 86, p. 286-291.
  23. Jen A., Baroody F. et al. As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis. J. Allergy Clin. Immunol. 2000, v. 105, p. 732-738.
  24. Dykewicz M.S., Kaiser H.B. et al. Fluticasone propionate aqueous nasal spray improves nasal symptoms of seasonal allergic rhinitis when used as needed (prn). Ann. Allergy Asthma Immunol. 2003, v. 91, p. 44-48.
  25. Craig T.J., Mende C., Hughes K. et al. The effect of topical nasal fluticasone on objective sleep testing and the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitis. Allergy Asthma Proc. 2003, v. 24 (1), p. 53-58.
  26. Daley-Yates P.T., Kunka R.L., Yin Y. et al. Bioavailability of fluticasone propionate and mometasone furoate aqueous nasal sprays. Eur. J. Clin. Pharmacol. 2004, v. 60, p. 265-268.
  27. Sheth K.K., Cook C.K., Philpot E.E. et al. Concurrent use of intranasal and orally inhaled fluticasone propionate does not affect hypothalamic-pituitary-adrenal-axis function. Allergy Asthma Proc. 2004, Mar-Apr, v. 25 (2), p. 115-120.
  28. Adams R.J et al. Intranasal steroids and the risk of emergency department visits for asthma J. Allergy Clin. Immunol 2002, v. 109, p. 636-42.

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