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Vol 7, No 4 (2010)


Clinical and immunological phenotypes of the chronic rhinosinusitis with polyposis

Mokronosova M.А., Ruyan J.S., Mustafaeva D.M., Smolnikova E.V., Protasov P.G.


The pathogenesis of chronic rhinosinusitis with nasal polyposis is still unknown. The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and sera of three phenotypes of chronic rhinosinusitis. Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitis with nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance - 10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines, fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB). Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp's tissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high and revealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependence between the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronic rhinosinusitis with nasal polyposis. Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than in sera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. The presence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .
Russian Journal of Allergy. 2010;7(4):3-9
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Fungal allergy in clinical practice

Tsarev S.V.


Epidemiologic data on atopic diseases with fungal sensitization is summarized in the review. Basic pathogenic aspects of fungal allergen associated disorders are presented. Fungi may adversely affect human health through three processes: allergy, infection and toxicity. Allergic reactions to fungi can be immediate or delayed. The most common form of hypersensitivity to molds is immediate (or IgE-mediated) type hypersensitivity.
Russian Journal of Allergy. 2010;7(4):11-31
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Features of lymphocytes during programmed cell death in patients with atopic bronchial asthma

Pinchuk Y.V., Vodunon A.C., Mustafin I.G., Abramova Z.I.


Background. To establish features of programmed cell death of lymphocytes depending on disease severity score. Methods. The morphology of lymphocytes was investigated with a method of electronic microscopy. Apoptotic cells were defined by flow cytometry. Results. We have revealed lymphocytes morphological difference between asthmatics and normal donors. Also we found out the difference between number of cells during the incubation process. Conclusion. These findings can promote deeper understanding of the disease pathogenesis.
Russian Journal of Allergy. 2010;7(4):32-39
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Topical immunotherapy influence on citokins genes expression in skin and blood in atopicdermatitis patients

Filimonova T.M., Elisyutina O.G., Fedenko E.S., Boldyreva M.N., Smirnov V.S.


Background. To study the clinical effectiveness of topical immune modulator cream thymogen 0,05% and its influence on some immunological parameters in the skin and blood of atopic dermatitis (AD) patients. Materials and methods. 40 people were included in the study, who were divided into main (AD patients, n=20) and a control group (healthy donors, n=20). All AD patients received topical treatment with cream thymogen 0,05% during 14 days. Patients applied cream to affected skin 2 times daily. Clinical efficacy of the treatment was assessed by changes of following parameters: investigated global assessment (IGA), subjective evaluation of the itch intensity and skin dryness . Samples of skin biopsies and peripheral blood of AD patients and healthy donors were tested for gene expression of cytokines by polymerase chain reaction in real time. Results. Topical treatment with cream thymogen 0,05% during 14 days in all AD patients showed positive clinical effect: reduction of dryness and itch. Immunological analysis revealed a significant increasing of cytokine IL-7 gene expression and decreasing of cytokines IL-8, IL-5 genes expression (p<0,05). In the peripheral blood no significant differences of cytokines genes expression before and after the treatment with cream thymogen 0,05% in comparison with healthy donors have been detected. Conclusion. Cream thymogen 0,05% showed a local immunomodulating activity resulted in the decreasing of the intensity of skin inflammation and clinical improvement in AD patients. Changes of cytokines genes expression in skin, but not in blood were identified.
Russian Journal of Allergy. 2010;7(4):40-45
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Reasons and mechanisms of organ remodeling in kidney, cardiovascular diseases and bronchialasthma

Pytsky V.I.


Organ and system remodeling is a very common process and is observed in some kidney, cardiovascular, GI, liver diseases and bronchial asthma. Main mechanism is tissue fibrosis in organs with excessive function.
Russian Journal of Allergy. 2010;7(4):46-53
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Pimecrolimus 1 % cream in treatment of steroid rosacea in AD patients

Elisyutina O.G., Fedenko E.S.


The own data concerning cream pimecrolimus 1% application in atopic dermatitis patients complicated with steroid rosacea are presented.
Russian Journal of Allergy. 2010;7(4):54-57
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OLYMP programme-basic clinical immunology programme as a part of continued medical education for pediatritiansGeneral aspects of immune response generation. Clinical and laboratory assessment of immune dysfunction

Shcherbina A.Y.


Immune system consists of innate and adaptive immunity and functions to prevent our body from microorganisms intrusion, as well as to continuously remove damaged cells. Proper function of immune system depends on maturation and coordinated activation of its different components. Inborn or acquired defects of immune components cause immunodeficiencies. Primary care physicians alertness and availability of specialized laboratory methods of assessment of cellular and humoral immunity, complement and phagocytosis are important for up-to-date diagnosis of these disorders.
Russian Journal of Allergy. 2010;7(4):58-66
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Allergic rhinitis and it's impact on asthma (ARIA 2008) (Part 6)

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Russian Journal of Allergy. 2010;7(4):67-72
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Microdisperse cellulose powder for prevention of allergic rhinitis in children

Geppe N.A., Snegotskaya M.N., Kolosova N.G., Konopelko O.U., Mashukova N.G., Ozerskaya I.M., Farber I.M.


The data of open comparative clinical study is given according to efficiency and safety of microdisperse cellulose powder used for prevention and treatment of allergic rhinitis in children.
Russian Journal of Allergy. 2010;7(4):73-78
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Specific subcutaneus immunotherapy by a birch extract absorbed onto calcium phosphate

Mokronosova M.A., Korovkina E.S.


Background. Allergic rhinitis is a common disease, affecting 25-35% of the population. Birch pollen is a significant cause of immediate hypersensitivity among sensitive subjects, affecting about 80% of the population in the central part of Russian Federation. Specific subcutaneus immunotherapy (SCIT) is the only treatment producing lasting clinical improvement in patients with allergy. The aim, of the study was to investigate the efficacy of one - year SCIT for allergic rhinoconjunctivitis for birch pollen using the Average Rhinoconjunctivitis Total Symptom Score (ARTSS) and Average Rescue Medication Score (ARMS). Materials and methods. 54 subjects with IgE-mediated seasonal allergic rhinoconjunctivitis with/without seasonal asthma were enrolled; 47 patients with pollen allergy were included in a control group. All patients were sensitized to birch pollen-allergens. SCIT was performed during 9 months 2009-2010 years by a birch extract standardized in IR and absorbed onto calcium phosphate (Phostal, France). Patients were asked to complete diary during the birch pollination season (from 1 April to 1 June). Pollen grains were counted daily during the pollen seasons by standardized protocol and the amount of pollen was expressed as the number of pollen grains/m3 air. The ARTSS was derived from individual symptom scores for nasal and eye symptoms during the pollen season. In addition there was a daily score for the use of rescue medication (ARMS). Rescue medication allowed included Hl-antihistamines, nasal steroids, oral steroids; each puff, drop (nostril/eye), tablet counted as one point. Results. The seasonal pollen counts and the duration of the pollen season had differed in 2009 and in 2010. Reduction in ARTSS of 29% and decrease in ARMS of 28,9% were found in the birch pollen season for subjects treated with the SCIT compared with controls after one year of treatment. The immunotherapy after the end of the treatment was not effective in 3 patients (5%). Conclusion. Immunotherapy by Phostal shows clinical effect on development of seasonal rhinoconjunctivitis. The decrease in ARTSS for Phostal-treated patients that occurred in parallel with a marked reduction in their requirement for ARMS provides additional evidence for the efficacy of SCIT over and above usual pharmacotherapy for rhinitis.
Russian Journal of Allergy. 2010;7(4):79-84
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Treatment approaches in small bronchi inflammatory control in bronchial asthma patients

Budnevskiy A.V., Burlachuk V.T., Olisheva L.


This article reviews the significance of distal airways inflammation in asthma, current methods of investigations and therapeutic approaches to control inflammation at the level of small bronchi. It is demonstrated that inflammation in most asthma patients involves all airways including the small bronchi. The new drugs targeting distal airways, including extrafine formulations of inhaled steroids and P2-agonists (beclomethazone/formoterol (Fostair), can successfully treat pathologic process in small bronchi of asthma patients.
Russian Journal of Allergy. 2010;7(4):85-94
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Gleb Borisovich Fedoseev (80th anniversary)

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Russian Journal of Allergy. 2010;7(4):96-96
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Congresses, Conferences

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Russian Journal of Allergy. 2010;7(4):97-97
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Instructions for Authors

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Russian Journal of Allergy. 2010;7(4):98-100
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