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Vol 8, No 2 (2011)

Articles
DEVELOPMENT OF ASIT METHOD DURING THE 1920-60S -BEFORE IGE DISCOVERY
Vorob'eva O.V., S Gushchin I., Vorobyeva O.V., Gushchin I.S.
Abstract
We conducted a historical analysis of the successive development and improvement of theory, methodology and application of ASIT method in 1920-60s- the period prior to fundamental discoveries in allergology and immunology.
Russian Journal of Allergy. 2011;8(2):3-12
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PNEUMOCOCCAL DISEASE: ABERRATIONS, FACTS AND FACILITIES OF VACCINE PROPHYLAXIS
Salkina O.A., Snegova N.F., Chernousov A.D., Salkina O.A., Snegova N.F., Tchernousov A.D.
Abstract
The article presents information about the microbiology, epidemiology, clinical appearance and specific prevention of pneumococcal infections. Modern data on the pathogenesis and risk factors and comparative characteristics of polysaccharide and conjugate pneumococcal vaccines are discussed.
Russian Journal of Allergy. 2011;8(2):13-21
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MUCOSAL IMMUNITY IN THE UPPER AIRWAYS DYSFUNCTION
Tsyvkina A.A., Luss L.V., Tsarev S.V., Tsyvkina A.A., Luss L.V., Tsarev S.V.
Abstract
Mucosal immunity of the upper respiratory tract acts the role of immune defence against antigens by means of nonspecific protective factors of a mucous membrane. Disruptions of mucosal immunity are observed in various diseases of oral cavity (stomatitis, dysfunctions of salivary glands, etc.), ETN diseases (rhinitis, sinusitis, tonsillitis, nasal polyposis, etc.), bronchopulmonary diseases (chronic bronchitis, pneumonias, etc.).
Russian Journal of Allergy. 2011;8(2):22-26
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ALGORITHM OF ASSESSMENT OF ASTHMA CONTROL
Nazarova E.V., Kurbacheva O.M., Il'ina N.I., Nazarova E.V., Kurbacheva O.M., Ilina N.I.
Abstract
Background. To study informativeness, clinical significance and relationship between objective and subjective methods of assessing asthma control and creation an optimal algorithm. Methods. The study involved 40 patients of both sex, aged from 18 to 75 years old suffering from persistent, moderate and severe asthma , having no control. Results. All patients were assessed asthma control using methods based on subjective data (medical history, filling the questionnaires: the ACT and AQLQ; survey on the presence of comorbidity) and objective methods of examination (auscultation, PEV, spirometry, ECP in blood, content of eosinophils in induced sputum and peripheral blood). All patients were assigned to anti-asthma therapy combination therapy (ICS+LABA). The main reasons for lack of asthma control is the inadequacy of basic therapy and concomitant diseases. Symptoms and normalization of ERF occur much earlier (on day 30 of therapy) than the relief of bronchial inflammation. Adequate methods to assess asthma control are objective methods, subjective can only be used as an extra. Conclusion. The analysis of the causes of asthma control in each individual case, increased medical supervision over appointments and continuous monitoring by means of subjective and objective ways of assessing control, avoid excessive use of pharmaceutical loads, to minimize the side effects of treatment, faster to achieve better results by optimizing costs treatment.
Russian Journal of Allergy. 2011;8(2):27-33
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NEUTROPHILS AND RESPIRATORY TRACT BACTERIAL INFECTIONS IN PATIENTS WITH BRONCHIAL ASTHMA AND COPD
Fedoseev G.B., Trofimov B.I., Rogacheva N.N., Razumovskaya T.S., Fedoseev G.B., Trofimov V.I., Rogacheva N.N., Razumovskaya N.S.
Abstract
The article concerns the role of respiratory tract bacterial infections in development of bronchial asthma and COPD. Analysis is based on current publications and results of clinical investigations. Ability of neutrophils to protect the respiratory system from bacterial agents is underlined. The results obtained during investigation of 132 bronchial asthma and 33 COPD patients showed that in allergic asthma patients high percentage of sputum neutrophils is associated with normal FEV1% and mild course of the disease. In COPD patients high percentage of sputum neutrophils is usually associated with low FEV1%. It is proposed, that in these patients functional activity of neutrophils is associated with predominant injury of respiratory structures.
Russian Journal of Allergy. 2011;8(2):34-43
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CHANGES IN BRONCHIAL ASTHMA CONTROL AND INFLAMMATION BIOMARKERS DURING THE ALLERGEN-SPECIFIC IMMUNOTHERAPY AND ACCOMPANYINGTREATMENT
Eliseeva T.I., Kul'gina Y.S., Balabolkin I.I., Eliseeva T.I., Kulgina U.S., Balabolkin I.I.
Abstract
Background. The work is devoted to the studying of the correspondence between the symptoms dynamics and the concentrations of the nitrogen oxide (NO) methabolites in the exhaled breath air condensate in patients with bronchial asthma (BA) during allergenospecific immunotherapy (ASIT) and accompanying treatment. Methods. The symptoms of BA were estimated using the Asthma Control Questionaire (ACQ). The inflammation biomarkers level (NO methabolites in the exhaled air condensate) was measured by the spectrofluorometric method of Griess. Results. During ASIT and accompanying treatment (cetirizine or levocetirizine with basis BA therapy corresponding to the observed BA severity with allergens eliminated), the symptoms reduction (decrease in the total ACQ scores) was observed along with decrease of the total concentration of NO metabolites in blood. This was observed both for the steroid- naive patients and for the patients taking the inhaled corticosteroids (IC) treatment. Conclusion: In patients with mild BA, combination of ASIT and non-steroid accompanying therapy on the basis of cetirizine or levocetirizine results in the improvement of the BA control and reduction of the allergic inflammation in airways comaparable to the analogous processes in patients with moderate BA taking the analogous therapy but with IC included.
Russian Journal of Allergy. 2011;8(2):44-50
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DIET THERAPY AS PROFILAXIS AND TREATMENT OF FOOD ALLERGY IN INFANTS
Revyakina V.A., Lavrova T.E., Revjakina V.A., Lavrova T.Y.
Abstract
This review is devoted to profilaxis of food allergy in infants. Brest feeding and or partially hydrolized milk formula considered to be mandatory used in infants with high risk of allergy.
Russian Journal of Allergy. 2011;8(2):51-56
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ALLERGIC RHINITIS AND IT'S IMPACT ON ASTHMA (ARIA 2008) (PART 9)
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Russian Journal of Allergy. 2011;8(2):57-67
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MODERN PROBLEMS OF ALLERGEN VACCINES STANDARDIZATION
Zheltikova T.M., Hrabina M., Antropova A.B., Zheltikova T.M., Hrabina M., Antropova A.B.
Abstract
The article deals with the problems of standardization of allergen vaccines for ASIT performing. At present time there are no uniform requirements, criteria and methods which allow to standardize these preparations. There upon information about preparation or cultivation of raw materials, about methods used for allergen vaccines biological activity evaluation, and about units for this activity expression is very important for choosing the preparation for ASIT. The information about major clinically significant allergens concentration is necessary because ASIT both effectiveness and safety depend on it. Phostal and Staloral are examples of these thoroughly characterized and standardized allergen vaccines.
Russian Journal of Allergy. 2011;8(2):68-72
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ТREATMENT AND PREVENTIVE ACTION OF NASAL SPRAY NAZAVAL IN THE ALLERGIC RHINITIS PATIENTS. CLINICAL RESEARCHES REVIEW
Il'ina N.I., Kurbacheva O.M., Mikeladze K.P., Pavlova K.S., Shvets S.M., Ilina N., Kurbacheva O., Mikeladse K., Pavlova K., Shvets S.
Abstract
The mechanism of action and efficiency of Nazaval representing a powder of natural cellulose, new to the Russian pharmaceutical market, creating barrier on a way of contact of allergen with a nose mucous membrane is considered. Clinical efficiency of a preparation at adults and children with a seasonal and perennial rhinitis is shown. Preventive action of Nasaval was developed in provocation tests with allergen.
Russian Journal of Allergy. 2011;8(2):73-80
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TREATMENT OF VIRAL AND BACTERIAL INFECTIONS IN IMMUNOCOMPROMISED CHILDREN
Nesterova I.V., Kleshchenko E.I., Kovaleva S.V., Alekseeva O.N., Lomtatidze L.V., Chudilova G.A., Nesterova I.V., Klethshenko E.I., Kovaleva S.V., Alekseeva O.N., Lomtatidze L.V., Chudilova G.A.
Abstract
Частые острые респираторные инфекции у детей раннего возраста (более 8-12 раз в год) рассматриваются некоторыми авторами как проявления вторичной иммунной недостаточности, а таких детей относят к группе часто и длительно болеющих (ЧДБ). При вторичных иммунодефицитах, ассоциированных с инфекционным синдромом, одним из обязательных условий проведения иммуномодулиру-ющей терапии является выполнение ее в рамках традиционного лечения. Представлены основные принципы терапии интерфероном человеческим рекомбинантным альфа-2 (Вифероном), тактика проведения иммунотропной терапии при вторичных иммунодефицитах с синдромом повторных острых респираторных вирусных, вирусно-бактериальных инфекций и программа виферонотерапии для ЧДБ детей.
Russian Journal of Allergy. 2011;8(2):81-88
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ТHE EFFICIENCY AND SAFETY OF CALCINEURIN INHIBITORS (TACROLIMUS) IN ATOPIC DERMATITIS AND OTHER DERMATOLOGICAL DISEASES
Ochelenko S.A., Monakhov K.N., Ochelenko S.A., Monakhov K.N.
Abstract
The problems of clinical efficiency and safety of application of tacrolimus (Protopik) at various skin diseases are discussed in this review. High efficiency of this drug, allows to use it in treatment of different dermatosis. The clinical effect is comparable with topical corticosteroids, and the rate of adverse effects is lower. It is possible to use long applications of calcineurin inhibitors in patients with resistant forms of atopic dermatitis. Positive effects of application of tacrolimus in vitiligo, balanitis, alopecia areata etc. are described.
Russian Journal of Allergy. 2011;8(2):89-95
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IMMTJNOTROPIC THERAPY OF SEVERE ACNE IN MALE PATIENTS
Pavlenko T.Y., Sizyakina L.P., Sidorenko O.A., Pavlenko T.J., Siziakina L.P., Sidorenko O.A.
Abstract
Background.The aim of the study was to estimate the efficacy of systemic and topic immunotropic therapy in complex treatment of acne disease. Methods. 48 male patients with moderate to severe acne at the age from 16 to 34 years old were investigated. The patients of the control group were treated with standard methods and the patients of the experimental group were treated with complex of immunotropic medicines. All of them were examined with immunological methods, Cook scale and Vancouer scarring index. Results. High efficacy and fast positive dynamics were shown in patients who received complex therapy, consisting of standard drugs, systemic and topic immunotropic medicines. Conclusion. The results of this study show the efficiency of immunotropic treatment in complex therapy of moderate and severe acne disease.
Russian Journal of Allergy. 2011;8(2):96-99
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Congresses, Conferences
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Russian Journal of Allergy. 2011;8(2):100-103
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Instructions for Authors
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Russian Journal of Allergy. 2011;8(2):104-107
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