MODERN PROBLEMS OF ALLERGEN VACCINES STANDARDIZATION



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Abstract

The article deals with the problems of standardization of allergen vaccines for ASIT performing. At present time there are no uniform requirements, criteria and methods which allow to standardize these preparations. There upon information about preparation or cultivation of raw materials, about methods used for allergen vaccines biological activity evaluation, and about units for this activity expression is very important for choosing the preparation for ASIT. The information about major clinically significant allergens concentration is necessary because ASIT both effectiveness and safety depend on it. Phostal and Staloral are examples of these thoroughly characterized and standardized allergen vaccines.

About the authors

Tat'yana Mikhaylovna Zheltikova

Email: t-zheltikova@yandex.ru <mailto:t-zheltikova@yandex.ru>

M Hrabina

A B Antropova

T M Zheltikova

Mechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences

Mechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences

M Hrabina

Departement Scientifique et Medical, Stallergenes S.A., Antony, France

Departement Scientifique et Medical, Stallergenes S.A., Antony, France

A B Antropova

Mechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences

Mechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences

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