Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media80310.36691/RJA803MODERN PROBLEMS OF ALLERGEN VACCINES STANDARDIZATIONZheltikovaTat'yana Mikhaylovnat-zheltikova@yandex.ru <mailto:t-zheltikova@yandex.ru>HrabinaM-AntropovaA B-ZheltikovaT MMechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences-HrabinaMDepartement Scientifique et Medical, Stallergenes S.A., Antony, France-AntropovaA BMechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical Sciences-Mechnikov Research Institute for Vaccines and Sera of the Russian Academy of Medical SciencesDepartement Scientifique et Medical, Stallergenes S.A., Antony, France1504201182687210032020Copyright © 2011, Pharmarus Print Media2011The article deals with the problems of standardization of allergen vaccines for ASIT performing. At present time there are no uniform requirements, criteria and methods which allow to standardize these preparations. There upon information about preparation or cultivation of raw materials, about methods used for allergen vaccines biological activity evaluation, and about units for this activity expression is very important for choosing the preparation for ASIT. The information about major clinically significant allergens concentration is necessary because ASIT both effectiveness and safety depend on it. Phostal and Staloral are examples of these thoroughly characterized and standardized allergen vaccines.allergen vaccinesstandardizationreference preparationsаллерговакциныстандартизацияреференс-препараты[WHO Position Paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Editors Bousquet J., Lockey R.F., Malling H.J. Allergy. 1998, v. 53, suppl. 44, 42 p.][Esch R.E. Evaluation of allergen vaccine potency. Curr. 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