CHANGES IN BRONCHIAL ASTHMA CONTROL AND INFLAMMATION BIOMARKERS DURING THE ALLERGEN-SPECIFIC IMMUNOTHERAPY AND ACCOMPANYINGTREATMENT

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. The work is devoted to the studying of the correspondence between the symptoms dynamics and the concentrations of the nitrogen oxide (NO) methabolites in the exhaled breath air condensate in patients with bronchial asthma (BA) during allergenospecific immunotherapy (ASIT) and accompanying treatment. Methods. The symptoms of BA were estimated using the Asthma Control Questionaire (ACQ). The inflammation biomarkers level (NO methabolites in the exhaled air condensate) was measured by the spectrofluorometric method of Griess.
Results. During ASIT and accompanying treatment (cetirizine or levocetirizine with basis BA therapy corresponding to the observed BA severity with allergens eliminated), the symptoms reduction (decrease in the total ACQ scores) was observed along with decrease of the total concentration of NO metabolites in blood. This was observed both for the steroid- naive patients and for the patients taking the inhaled corticosteroids (IC) treatment. Conclusion: In patients with mild BA, combination of ASIT and non-steroid accompanying therapy on the basis of cetirizine or levocetirizine results in the improvement of the BA control and reduction of the allergic inflammation in airways comaparable to the analogous processes in patients with moderate BA taking the analogous therapy but with IC included.

About the authors

T I Eliseeva

Email: eliseevati@yandex.ru <mailto:eliseevati@yandex.ru>

Yu S Kul'gina

I I Balabolkin

T I Eliseeva

Nigny Novgorod State Medical Academy

Nigny Novgorod State Medical Academy

U S Kulgina

Nigny Novgorod State Medical Academy

Nigny Novgorod State Medical Academy

I I Balabolkin

Research Centre of Children's Health, Russian Academy of Medical Sciences, Moscow

Research Centre of Children's Health, Russian Academy of Medical Sciences, Moscow

References

  1. Национальная программа. Бронхиальная астма у детей. Стратегия лечения и профилактика. М., «Русский врач». 2008, 107 с.
  2. GINA Глобальная стратегия лечения и профилактики бронхиальной астмы (пересмотр 2007 г.). М., «Атмосфера». 2008, 108 с.
  3. Holgate S., Bisgaard H., Bjermer L. et al. The Brussels Declaration: the need for change in asthma management. Eur. Respir. J. 2008, v. 32, p. 1433-1442.
  4. Kepley C.L. New approaches to allergen immunotherapy. Curr. Allergy Asthma Rep. 2006, 6, No. 5, р. 427-433.
  5. Гущин И.С. Аллергенспецифическая иммунотерапия (гипосенсибилизация). Леч. врач. 2001, № 3, с. 10-27.
  6. Курбачева О.М. Аллергенспецифическая иммунотерапия: история и перспективы совершенствования. Цитокины и воспаление. 2005, № 3, c. 122-127.
  7. Akdis C.A., Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T-cells. Journal of Allergy and Clinical Immunology. 2009, 123 (4), p. 735-746.
  8. Nagata M., Saito K., Kikuchi I. et al. Immunotherapy attenuates eosinophil transendothelial migration induced by the supernatants of antigen-stimulated mononuclear cells from atopic asthmatics. Int. Arch. Allergy Immunol. 2004, v. 134, Suppl. 1, p. 21-24.
  9. Asthma: still more questions than answers. The Lancet. 2008, v. 372, No. 9643, p. 1009.
  10. Holgate S.T., Arshad H.S., Roberts G.C., Howarth P.H., Thurner P., Davies D.E. A new look at the pathogenesis of asthma. Clinical Science. 2010, No. 118, p. 439-450.
  11. Abramson M.J., Puy R.M., Weiner J.M. Allergen immunotherapy for asthma. Cochrane Database of Systematic Reviews. 2003, No.:CD001186. doi: 10.1002/14651858.CD001186.
  12. Nagata M., Nakagome K. Allergen Immunotherapy in Asthma: Current Status and Future Perspectives. Allergology International. 2010, No. 1, p. 15-19.
  13. Guilbert T.W., Morgan W.J., Zeiger R.S. et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N. Engl. J. Med. 2006, No. 354, p. 1985-1997.
  14. Busse W.W., Pedersen S., Pauwels R.A. et al. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma ( START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J. Allergy Clin. Immunol. 2008, No. 121, p. 1167-1174.
  15. Курбачева О.М. Применение аллергенспецифической иммунотерапии в лечении атопических заболеваний. Леч. врач. 2003, № 3, c. 26-31.
  16. Nielsen L., Johnsen C.R., Mosbech H., Poulsen L. K., Malling H.J. Antihistamine premedication in specific cluster immunotherapy: a double-blind, placebo-controlled study. J. Allergy Clin. Immunol. 1996, v. 97, No. 6, p. 1207-1213.
  17. Müller U., Hari Y., Berchtold E. Premedication with antihistamines may enhance efficacy of specific-allergen immunotherapy. J. Allergy Clin. Immunol. 2001, v. 107, No. 1, p. 81-86.
  18. Allergen immunotherapy: a practice parameter second update. J. Allergy Clin. Immunol. 2007, v. 120, No. 3, Suppl, p. 25-85.
  19. Szefler S.J. Advances in pediatric asthma in 2009: Gaining control of childhood asthma. Journal of Allergy and Clinical Immunology. 2009, v. 125 (1), p. 69-78.
  20. Juniper E.F., Gruffydd-Jones K., Ward S., Svensson K. Asthma control questionnaire in children validation, measurement properties, interpretation. Eur. Respir. J. 2010, No. 7, p. Published online.
  21. Barnes P.J., Liew F.Y Nitric oxide and asthmatic inflammation. Immunol. Today. 1995, v. 16 (3), p. 128-30.
  22. Климанов И.А. Изучение метаболизма оксида азота при бронхиальной астме. Автореферат диссертации канд. мед. наук. М., 2006, 24 с.
  23. Геппе Н.А., Соодаева С.К., Белоусова Е.Г. и соавт. Оксид азота как маркер воспаления при бронхиальной астме. Вопр. практ. педиатр. 2007, № 4, c. 27-31.
  24. Dinakar C., Van Osdol T.J., Barnes C.S., Dowling P.J., Zeigler A.W. Changes in exhaled nitric oxide levels with immunotherapy. Allergy Asthma Proc. 2006, v. 27 (2), p. 140-144.
  25. Hung C.H., Lee M.Y., Tsai YG., Cheng S.N., Yang K.D. Hyposensitization therapy reduced exhaled nitric oxide in asthmatic children with corticosteroid dependency. Acta Paediatr Taiwan. 2004, v. 45 (2), p. 89-93.
  26. Балаболкин И.И., Сенцова Т.Б., Булгакова В.А. и соавт. Эффективность ускоренного метода парентеральной аллергеспецифической иммунотерапии при атопической бронхиальной астме у детей и подростков. Педиатрия. Журнал им. Г.Н. Сперанского. 2007, № 4, с. 11.
  27. Griess P. Bemerkungen zu der Abhandlung der HH. Weselky und Benedikt «Ueber einige Azoverbindungen». Berichte der Deutschen chemischen Gesellschaft. 1879, v. 12, p. 426-428.
  28. Климанов И.А., Соодаева С.К., Лисица А.В., Чучалин А.Г. Изменения метаболизма оксида азота при поллинозе и бронхиальной астме. Пульмонология. 2006, № 4, c. 30-38.

Statistics

Views

Abstract: 105

Article Metrics

Metrics Loading ...

Dimensions

PlumX


Copyright © Pharmarus Print Media, 2011



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies