Vol 13, No 6 (2016)

Articles
Editorial
Khaitov R.m., Il'ina N.I.
Russian Journal of Allergy. 2016;13(6):3-3
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The basic and applied medical research in the Russian Federation: differentiation, prioritization, funding channels
Rebrova O.Y.
Abstract
Currently, there is no consistent view for the differentiation of basic and applied medical research in the Russian medical research community. Priority areas of applied science (but not fundamental) can be determined by the state on the basis of scientific methods and mechanisms implemented through competitive funding. The state as a qualified customer of applied research can be an important component of the development of Russian medical science.
Russian Journal of Allergy. 2016;13(6):4-10
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Solar urticaria
Belan E.B.
Abstract
Solar urticaria is defined as relatively rare photodermatosis induced by visible or ultraviolet (A) light. The diagnosis of the disease is based on the anamnesis and phototesting data. Management of the solar urticaria includes dark clothes, sunscreens, non-sedative antihistamines. Alternative interventions may be considered if high doses of non-sedative antihistamines are ineffective.
Russian Journal of Allergy. 2016;13(6):11-17
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Immune parameters in moderate seasonal allergic rhinitis
Sizyakina L.P., Andreeva I.I., Semenova N.I.
Abstract
The results of the immune parameters changes of 29 moderate seasonal allergic rhinitis patients are presented in this study. The humoral and cellular parameters of innate and adaptive immune system were investigated during clinical manifestation and remission. The interpretation of the obtained data according to pathogenetic principle showed no difference between recognition phase, active phase or remission phase. The number of peripheral Treg cells was reduced only in the active phase, at the same time Il-4, CD3+CD8+Gr+, IgA, IgE - indicators of effector phase remained elevated during clinical remission.
Russian Journal of Allergy. 2016;13(6):18-22
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Regarding to the issue of the role of cytokines in the pathogenesis of asthma and the possibilities of anticytokine therapy
Fedoseev G.B., Trofimov V.I., Negrutsa K.V., Timchik V.G., Golubeva V.I., Aleksandrin V.A., Razumovskaya T.S., Kryakunov K.N.
Abstract
The study involved 210 people, of which 32 had mild bronchial asthma, 39 had moderate bronchial asthma, 39 had moderate bronchial asthma combined with chronic obstructive pulmonary disease, 38 had chronic obstructive pulmonary disease, 17 patients suffered from community-acquired pneumonia, 25 patients with essential hypertension and ischemic heart disease (comparison group) and 20 healthy patients. We assessed sIgE to mite allergens, dust allergens, and the mixed grass, trees, weeds and flower pollen allergens , Str. pneumon., Haemofil. influenzae, Neisseria perflava. The levels of interleukin-4, interleukin6, interleukinlO, interleukin-7, gamma-interferon, tumor necrosis factor were investigated. All patients were studied in the acute condition of the disease. We assessed the infectious potential and atopic potential in every patient. Results of the study allow to resume that cytokines levels, their combinations (cytokine profile) testing has not to be advisable for clinical diagnostics, assessement of the severity of the disease and treatment strategy including anti-cytokine therapy.
Russian Journal of Allergy. 2016;13(6):23-36
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Allergic bronchopulmonary aspergillosis in patients with asthma: dynamics of immunological parameters during antimycotic therapy
Kozlova Y.I., Sobolev A.V., Frolova E.V., Uchevatkina A.E., Filippova L.V., Aak O.V., Shurpitskaya O.A., Klimko N.N.
Abstract
Background. To determine the frequency of allergic bronchopulmonary aspergillosis in patients with asthma and to study the dynamics of immunological parameters in patients with allergic bronchopulmonary aspergillosis during antimycotic therapy. Methods. During investigation of 176 patients with asthma the group of patients with allergic bronchopulmonary aspergillosis was isolated. Allergological (skin tests with fungal allergens, serum total IgE, specific IgE to fungal allergens), immunological (IFN-γ, IL-10) and mycological (microscopy and culture of respiratory samples) examination was performed. Computer tomography of the chest was done when indicated. Results. In patients with asthma frequency of sensitization to Aspergillus spp. was 27%, with allergic bronchopulmonary aspergillosis - 4%. The increased activity of T-helper type 2 in patients with allergic bronchopulmonary aspergillosis (n=7) was revealed. After itraconazole treatment during 24 weeks serum total IgE reduced (p=0,04), spontaneous and induced production of IFN-γ ratio was normalized. The reduction of the absolute number of eosinophils in 4 (80%) patients, decreased production of sIgE to Aspergillus spp. in 3 (60%) patients were noted. Conclusion. All patients with severe asthma needed additional allergological and mycological examination for the detection of allergic bronchopulmonary aspergillosis. Itraconazole therapy was effective, reduced fungal burden, and resulted to restoring of Th2/Th1 imbalance in patients with allergic bronchopulmonary aspergillosis.
Russian Journal of Allergy. 2016;13(6):37-42
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Allergen-specific immunotherapy with monomeric allergoid from house dust mites dermato-phagoides pteronyssinus in a mouse allergic rhinitis model
Laskin A.A., Babakhin A.A., Kamishnikov O.Y., Gushchin I.S., Khaitov M.R.
Abstract
Background. The aim of this study was to investigate the efficacy of the allergen-specific immunotherapy (ASIT) with monomeric allergoid (sD1) obtained by succinylation of the allergenic extract from house dust mite Dermatophagoides pteronyssinus (D. pteronyssinus) (D1) in experimental mouse allergic rhinitis model (MARM). Materials and methods. BALB/c mice were immunized with non-modified extract D1 from house dust mite D. pteronyssinus (Der p) in mixture with aluminum hydroxide [Al(OH)3] three times in a three week intervals and then in 6 weeks after the last immunization were challenged with allergenic extract D1 by intranasal administration. Experimental ASIT was performed during the interval between the last immunization and the beginning of challenge. The first group of animals was treated with «sham ASIT» receiving of 16 subcutaneous (s.c.) injections of phosphate-buffered saline (PBS); the second group received 16 s.c. injections of non-modified D1 in increasing doses (in protein equivalent): 1; 10; 100 and 1000 pg/mouse; the third group received 8 s.c. injections ofsDl in increasing doses (in protein equivalent): 100; 550 and 1000 pg/mouse; the fourth group received combined ASIT consisted of 4 s.c. injections of sD1 in doses (in protein equivalent): 100; 550; 1000 pg/mouse and 4 sublingual (s.l.) administrations of sD1 in a dose of 1000 pg/mouse. The fifth group served as a negative control and received sham immunization, ASIT and challenge with PBS. Immediately after the last challenge and 24 hours later the clinical signs of MARM: sneezings (counts per minute) and breath frequency (assessed by non-invasive plethysmography) were evaluated. 48 hours after the last challenge animals of all groups were sacrificed and necessary material (whole head) was collected for histological assessment of the severity of allergic rhinitis in the nasal cavity. To obtain sera samples blood was collected from all groups of animals three times: 7 days after final immunization, 1 day before the challenge and 24 hours after the last challenge. Levels of anti-Der p IgE, IgG1, IgG2a in individual sera samples were determined by enzyme-linked immunosorbent assay (ELISA). Results. It is shown that all three variants of ASIT (groups 2, 3, 4) significantly reduced the number of sneezing acts. The greatest decrease was seen in the group 3 which was treated s.c with monomeric allergoid sD1. The number of respiratory acts per minute in the animals of groups 2 and 4 treated with non-modified D1 and monomeric allergoid sD1 (combined ASIT - s.c. and s.l. administration) respectively, were significantly higher than that of group 1 (MARM). The levels of anti-Der p IgE in groups 1, 2, 3 and 4 were increased after the 3rd immunization in comparison with group 5 (negative control). After ASIT the levels of anti-Der p IgE in groups 2, 3 and 4 were elevated in compare to group 5 (negative control) and group 1 (positive control - MARM). However, after the challenge the highest levels of anti-Der p IgE were observed in groups 1 and 4, while in group 3 we saw a moderate decrease of anti-Der p IgE and in the group 2 the levels of anti-Der p IgE were significantly lower than that of group 1 (MARM). The levels of anti-Der p IgG1 were significantly increased in groups 2, 3, 4 during and after ASIT as well as after challenge. The levels of anti-Der p IgG2a in groups 3 and 4 demonstrated a trend of increasing after ASIT. Anti-Der p IgG2a levels in group 4 after the challenge were significantly higher than that of group 1 (MARM). Histological evaluation has shown that overall inflammation, mucous exudation, hyperplasia of the mucosa in the nasal cavity were expressed significantly in groups 1 and 2 in comparison with group 5 (negative control). At the same time group 2 demonstrated a slight reduction of features designated above, and in groups 3 and 4 (ASIT with sD1 and combined s.c/s.l. ASIT, respectively) we observed a complete suppression of these inflammation parameters. Conclusion. These data indicate that ASIT with monomeric allergoid from house dust mite D. pteronyssinus obtained by succinylation may be a novel safe and effective approach for the treatment of allergic rhinitis including carrying out of combined course of injectable and sublingual therapy that may enhance the effect of treatment and patients’ quality of life.
Russian Journal of Allergy. 2016;13(6):43-51
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Federal dinical recommendations. Allergic contact dermatitis (L23)
Fedenko E.S., Elisyutina O.G.
Russian Journal of Allergy. 2016;13(6):52-57
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Oral allergy syndrome in children with pollen sensitization in Tomsk region
Fedotova M.M., Fedorova O.S., Ogorodova L.M., Evdokimova T.A.
Abstract
Background. Oral allergy syndrome (OAS) is defined as immediate IgE-mediated allergic reaction localized in the oral mucosa and developing after consuming raw fruits, vegetables, nuts, legumes in pollen sensitized patients. Objective. To study the prevalence of OAS in children in the Tomsk region. Material. The cross-sectional study in random groups of primary schoolchildren aged 7-10 years (n=13 010) from the Tomsk region, Russia, was performed in frames of (EuroPrevall, № FP6-2006-TTC-TU-5 Proposal 045879). During the screening phase a survey with standardized questionnaire was carried out. Clinical stage (n=1288) included clinical interviewing with parents/guardians, the clinical examination of patients, skin prick testing with extracts of food and pollen allergens (ALK-Abello, Spain), measurement of specific IgE level in serum to food and pollen allergens, component resolved diagnostics (ImmunoCAP, Phadia, Sweden). Results. OAS registered in 13,71% of children with pollen sensitization. The main triggers were apples, carrots, peaches, peanuts. Main cause of OAS in the Tomsk region was cross-reactivity to Bet v 1 - homologues belonging to PR-10 family: to apple - Mal d 1 (r=0,92; p=0,01); to peach - Pru p1 (r=0,87; p=0,01); to peanut - Ara h 8 (r=0,74; p=0,01); to hazelnut - Cor a 1 (r=0,76; p=0,01); to carrot - Dau c 1 (r=0,54; p=0,01). Conclusion. OAS was observed in 13,71% of children with pollen sensitization and was developesed due to crossreactivity to the birch allergen Bet v 1.
Russian Journal of Allergy. 2016;13(6):58-62
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Clinical efficacy of subcutaneous and sublingual allergen-specific immunotherapy of allergic rhinitis and conjunctivitis
Kozulina I.E., Pavlova K.S., Kurbacheva O.M.
Abstract
Objective. To evaluate the efficacy and safety of subcutaneous and sublingual allergen-specific immunotherapy (AIT), a comparative pharmaco-economic analysis. Materials and methods. The study included 60 patients with allergic rhinitis and conjunctivitis with or without asthma induced by birch pollen. In the first group patients received subcutaneous AIT (SCIT) by «Phostal - allergen of trees pollen», in the second group - sublingual AIT (SLIT) by «Staloral - allergen of birch pollen». Results. All patients after the SCIT or SLIT in the first pollen season noted a decrease in the severity of nasal and conjunctival symptoms (SMD -1,93 [95% CI -2,39; -1,47] and -1,57 [95% CI -2,39; -0,75] for groups 1 and 2, respectively) and a decrease in the rescue medication requirement (SMD -1,98 [95% CI -2,57; -1,39] and -1,86 [95% CI -2,61; -1,11] for groups 1 and 2, respectively). There were no statistically significant differences between the SCIT and SLIT efficacy. After AIT in both groups there was a significant reduction in the cost of medication and medical services (on average 5 times). In a comparative pharmacoeconomic analysis «cost/efficacy» and «cost/utility» was showed comparable results of SCIT and SLIT.
Russian Journal of Allergy. 2016;13(6):63-69
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Medunitsin N.V 85th Anniversary
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Russian Journal of Allergy. 2016;13(6):70-71
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Congresses, conferences
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Russian Journal of Allergy. 2016;13(6):72-74
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