Vol 14, No 1 (2017)

At the present time there is no credible scientific evidence on the effectiveness of homeopathy in asthma, allergies and other diseases. In the available publications, Cochrane reviews, meta-analyzes of homeopathy effect comparable to placebo. From a scientific point of view, we did not receive an explanation mechanism of action of homeopathic dilutions of drugs, laid down in the concept of potentiation. In the light of the best available data to date there is no reason to include homeopathy in clinical guidelines for the treatment of patients with various diseases. To change the view of the value of homeopathic medicines need modern analytical methods, revealing the structure of the proposed pills and other medicines, and to study the true therapeutic homeopathy capabilities required to conduct comparative studies, clinical trials, appropriate medical science and made according to strict rules, adopted by the international medical community.

The article presents modern data on gasdermin B (GSDMB) gene involved in the control of cell cycle, apoptosis, terminal differentiation of epithelial cells and maintain barrier function of the skin.

Objectives. To estimate the prevalence of current asthma-like symptoms and current allergic diseases among preschool children and to determine the risk factors. Materials and methods. Cross-sectional study included children aged 3-6 years. The study was conducted in 5 towns of Altai region. Prevalence of allergic diseases was assessed using the Russian version of the ISAAC questionnaire. Results. According to questionnaire the prevalence of current asthma-like symptoms was 11,1%, current allergic rhinoconjunctivitis - 7,5%, current atopic dermatitis -12,3%. Out of 3205 children asthma was diagnosed in 0,9%, allergic rhinoconjunctivitis - in 3%, atopic dermatitis - in 7,9%. Family history of allergic diseases increases risk of development of the current asthma-like symptoms twice (OR=2,11; 95% CI=1,66-2,68), current allergic rhinoconjunctivitis by 2,8 times (OR=2,85; 95% CI=2,16-3,75), current atopic dermatitis by 4,6 times (OR=4,62; 95% CI=3,69-5,77). The male sex increases risk of the development of current asthma-like symptoms by 2,6 times (OR=2,63; 95% CI=1,17-5,93), current allergic rhinoconjunctivitis by 1,3 times (OR=1,35; 95% CI=1,03-1,76), smoking of parents on the first year of life of the child increases risk of development of current asthma-like symptoms by 1,6 times (OR=1,61; 95% CI=1,15-2,24), breastfeeding duration less than 6 months increases the risk of development of current atopic dermatitis by 1,6 times (OR=1,62; 95% CI=1,26-2,09; p<0,05). Conclusion. The prevalence of current asthma-like symptoms and current allergic diseases considerably exceeds the prevalence of medically verified diagnosis. Family history of allergic diseases, male sex, smoking parents and the short duration of breastfeeding increase the risk of development of allergic diseases in preschool age.

This review is devoted to analyses of data on efficacy and safety of bilastine in allergic diseases therapy.