Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press33410.36691/RJA334ArticlesСтатьиResearch ArticleContribution of polymorphic variant of rs7216389 gasdermin B (GSDMB) gene in the development of atopic diseasesВклад полиморфного варианта rs7216389 гена гасдермина B (GSDMB) в развитие атопических заболеванийLevashevaS VЛевашеваС ВEtkinaE IЭткинаЭ ИBabenkovaL IБабенковаЛ ИBiktashevaA RБикташеваА РSakaevaG DСакаеваГ ДPublic budgetary educational institution of higher education «Bashkir State Medical University» of Health Ministry of Russian Federationгосударственное бюджетное образовательное учреждение высшего профессионального образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской Федерации15022017141NO1 (2017)№1 (2017)333510032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/334

The article presents modern data on gasdermin B (GSDMB) gene involved in the control of cell cycle, apoptosis, terminal differentiation of epithelial cells and maintain barrier function of the skin.

В статье представлены современные данные о гене гасдермина В (GSDMB), участвующего в контроле клеточного цикла, апоптозе, терминальной дифференцировке эпителиальных клеток и поддержании барьерной функции кожи.

gasdermin B genebronchial asthmachildrenthe skin’s barrier functionген гасдермин Вбронхиальная астмадетибарьерная функция кожиGalanter J., Choudhry S., Eng C. et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am. J. Respir. Crit. Care Med. 2008, v. 177, р. 1194-1200.Garcia-Sanchez A., Isidoro-Garcia M., Garcia-Solaesa V. et al. Genome-wide association studies (GWAS) and their importance in asthma. Allergol. Immunopathol. 2014, v. 69, р. 3-16.Verlaan D.J., Berlivet S., Hunninghake G.M. et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am. J. Hum. Genet. 2009, v. 85, р. 377-393.Tamura M., Tanaka S., Fujii T et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics. 2007, v. 89, р. 618-629.Saeki N., Usui T., Aoyagi K. et al. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Gen. Chromosom. Cancer. 2009, v. 48, р. 261-271.Карунас А.С., Юнусбаев Б.Б., Федорова Ю.Ю. и соавт. Полногеномный анализ ассоциаций бронхиальной астмы в Волго-Уральском регионе России. Молекулярная биология. 2011, № 6, с. 911-920.Komiyama H., Aoki A., Tanaka S. et al. Alu-derived cis-element regulates tumorgenesis-dependent gastric expression of Gasdermin B (GSDMB). Gen. Genet. Syst. 2010, v. 85, р. 75-83.Barrett J.C., Hansoul S., Nicolae D.L. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease. Nat. Genet. 2008, v. 40, р. 955-962.Barrett J.C., Clayton D.G., Concannon P. et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 2009, v. 41, р. 703-707.Hirschfield G.M., Liu X., Xu C. et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N. Engl. J. Med. 2009, v. 360, р. 2544-2555.Tavendale R., Macgregor D.F., Mukhopadhyay S., Palmer N.A. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J. Allerg. Clin. Immunol. 2008, v. 121, р. 860-863.Portelli M.A., Hodge E., Sayers I. Genetic risk factors for the development of allergic disease identified by genome-wide association. Clin. Exp. Allergy. 2015, v. 45, р. 21-31.Moffatt M.F., Kabesch M., Liang L. et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007, v. 448, р. 470-473.Sergeant A., Campbell L.E., Hull P.R. et al. Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly. J. Invest. Dermatol. 2009, v. 129, р. 1042-1045.Bouzigon E., Corda E., Aschard H. et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N. Engl. J. Med. 2008, v. 359, р. 1985-1994.Madore А., Tremblay K., Hudson TJ., Laprise C. Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum. Genet. 2008, v. 123, р. 93-95.Sleiman M.A., Annaiah K., Imielinski M. et al. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J. Allergy Clin. Immunol. 2008, v. 122, р. 1225-1227.Wu H., Romieu I., Sienra-Monge J.J. et al. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy. 2009, v. 64, р. 629-635.Hirota T., Harada M., Sakashita M. et al. Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J. Allergy Clin. Immunol. 2008, v. 121, р. 769-770.Tomita K., Sakashita M., Hirota T et al. Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy. 2013, v. 68, р. 92-100.Yu J., Kang M.J., Kim B.J. et al. Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr. Pulmonol. 2011, v. 46, р. 701-708.Leung T.F., Sy H.Y et al. Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy. 2009, v. 64, р. 621-628.Bisgaard H., Bennelykke K., Sleiman M.A. et al. Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am. J. Respir. Crit. Care Med. 2009, v. 179, р. 179-185.Van der Hulst A.E., Klip H., Brand P.L. Risk of developing asthma in young children with atopic eczema: a systematic review. J. Allergy Clin. Immunol. 2007, v. 120, р. 565-569.