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Vol 7, No 6 (2010)

Articles
TREATMENT OF URTICARIA: TODAY AND TOMORROW
Borzova E.Y., Grattan C.H.
Abstract
Urticaria is a common disorder with diverse clinical presentations. Correct recognition of the different clinical patterns helps clinical assessment and treatment. The management of urticaria involves recognition of relevant disease associations, treatment of any identifiable external causes including infection, avoidance of drug, food and physical triggers and the appropriate use of pharmacological therapies. These can be divided into first, second and third line approaches. The choice of treatment will be influenced by many factors including drug licensing, safety, pattern of disease, its severity, pharmacoeconomic considerations and patient preference. Possible new therapeutic approaches on the horizon include new H1 antihistamines, H4 receptor antagonists, a histidine decarboxylase inhibitor under development and biological agents that target histamine - releasing autoantibody production and function.
Russian Journal of Allergy. 2010;7(6):5-13
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Immunological alterations i n patients with atopicdermatitis
Gevorkyan O.V., Ospelnikova T.P., Ershov F.I.
Abstract
This review is dedicated to analysis of immunological alterations in patients with atopic dermatitis, one of the most common allergic dermatosis, and includes data about the role of cytokines and interferon system in pathogenesis of this disease.
Russian Journal of Allergy. 2010;7(6):14-19
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ASSOCIATION OF IL5, CCL26 AND CCL5 GENE POLYMORPHISMSWITH ATOPIC BRONCHIAL ASTHMA
Voronko O.E., Dmitrieva-Zdorova E.V., Latysheva E.A., Aksenova M.G., Storozhakov G.I., Bodoev N.V.
Abstract
The purpose of the work. In order to investigate whether single nucleotide polymorphisms С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene contribute to atopic bronchial asthma development we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian patients from Moscow region. Materials and methods. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Results. There were associations neither of С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene with asthma nor with asthma severity. Conclusion. Therefore, we may conclude that genes responsible for activation and chemotaxis of eosinophils play an insignificant role in susceptibility to development of atopic bronchial asthma, and probably may influence indirectly specific processes that occur in asthma.-
Russian Journal of Allergy. 2010;7(6):20-24
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IMMUNE THERAPY INFLUENCE ON a-DEFENSIN LEVEL IN PERIPHERAL BLOOD NEUTROPHILES IN PYODERMIA PATIENTS
Tsyvkina E.A., Fedenko E.S., Budikhina A.S., Pinegin B.V.
Abstract
Background. The purpose was to investigate a-defensin levels in neutrophiles of pyodermia patients in comparison with healthy donors, to estimate clinical efficiency of glucosaminyl muramyl dipeptide (Licopid) and its influence on a-defensin levels. Materials and method. 31 patients with pyodermia and 17 healthy donors were investigated. Intracellular a-defensin levels in neutrophiles in the peripheral blood were estimated by flow cytometry with mouse anti-NPantibodies (Hy cult biotechnology). All patients with pyodermia were treated with Licopid 10 mg once a day within 10 days. Clinical and laboratory results were measured after 7-0 days course of treatment and one month after treatment. Results. The a-defensin level in patients with pyodermia was reduced in comparison with healthy donors. Immune therapy with licopid 10 mg once a day as a complex treatment lead to a-defensin level increase in leukocytes of peripheral blood. Conclusion. The treatment with licopid 10 mg a day lead to prolonged remission and to increase of endocellular a-defensin level. Definition of a-defensin levels can be useful for advisability and for selection of immune therapy in pyodermia patients. Thus, a decrease of a-defensin levels in pyodermia patients, possibly, is a marker of the chronic bacterial inflammation.
Russian Journal of Allergy. 2010;7(6):25-30
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IMMUNOTROPIC ACTIVITY OF SOUR MILK FERMENTEDCULTURES HYDROLISATE
Garanyan G.S., Oganesyan E.T., Khanferyan R.A.
Abstract
The object of research is the hydrolysate of the lactobacteria components of the polycomponent sour milk stock BKUglich №4 . The hydrolysate has been obtained by the fermentative hydrolysis with microbial rennin «eito» The biological activity of obtained hydrolysate has been examined. Bacteria lysate immunotropic effects have been found to be due to the increase of neutrophilic granulocyte phagocytic activity. It was supposed that the earlier studied hydrolysate antioxidant activity caused by the normalization of the phagocyte superxide anionradical production leads to the cell immunity normalization.
Russian Journal of Allergy. 2010;7(6):31-33
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ALLERGIC DISEASES PRIMARY PREVENTION IN CHILDREN: POSITIVE PREDICTIVE VALUE AND HIGH SPECIFICITY OF INFORMATION ON ALLERGIC DISEASES IN MALE RELATIVES
Treneva M.S.
Abstract
Background. Сhildren allergic diseases primary prevention could be advanced with exploration of positive predictive value (PPV), negative predictive value (NPV), sensitivity (Se) and specificity (Sp) of information on allergic diseases in a wide range of relatives. Methods. retrospective analytic cross-sectional study. 1974 relatives of 212 children with allergic diseases and 137 controls were questioned. Couples of children equally aged were grouped in «×2»tables for each relativetype. Se was calculated as relative' allergic disease probability in child with allergic disease. Sp was calculated as negative allergic disease relative' probability in negative allergic disease children. PPV was calculated as a probability of allergic diseased children in positive allergic disease relatives; NPV -as a probability of negative allergic diseased children in negative allergic disease relatives. Results. PPV was of high quantity in male relatives -father' father (86%), male cousins (80%), mother' father (77%), mother' brother (73%), father of a child (72%). Mother' PPV was under 65%. Sp of all relatives was of good quantity. The top levels belong to male relatives -father' father (97%), fathermother (94%), father' brother (91%), male cousins (91%), mother' brother (89%). NPV of all relatives was useless for clinical practitioner. Se was low in all relatives. Mother' Se was on top with 67%. So, male relatives'allergic disease importance is confirmed by high PPV and high Sp in grandfathers, uncles, male cousins. Conclusion. high PPV and high Sp of information on allergic disease in male relatives combine prognostic valid and specific risk criterion for allergic diseases in children. A child should be set for a primary prevention of allergic disease in case of allergic disease in grandfathers, or uncles, or male cousins, or child' father.
Russian Journal of Allergy. 2010;7(6):34-37
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Allergic rhinitis an dit's impact on asthma (ARIA 2008)(Part 8)
- -.
Russian Journal of Allergy. 2010;7(6):44-51
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CLINICAL EFFICIENCY AND ANTI-INFLAMMATORY ACTIVITYOF THERAPY IN CHILDREN WITH PERENNIAL ALLERGICRHINITIS
Petrov V.I., Maljuzhinskaya N.V., Shishimorov I.N., Razvalyaeva A.V.
Abstract
Background. Intranasal corticosteroids and nonsedating antihistamines are the drug classes most often prescribed to treat allergic rhinitis (AR). Treatment guidelines recommend a combination of these agents for moderate to severe AR. Objective: To compare the efficacy of mometasone furoate (MF) nasal spray plus desloratadine (DL) with that of monotherapy with the individual agents in 6-16 years old patients with perennial AR. Methods. A prospective, randomized, open label, parallel group study of the efficiency of MF nasal spray plus DL and of monotherapy with MF or DL in children with persistent allergic rhinitis aged 6-16 in a 12week period was conducted. The efficacy of therapy was evaluated by level of markers of an allergic inflammation, indicators of a bronchial hyperresponsiveness and by dynamics of clinical symptoms. Results. Combined therapy (DL+MF) restores balance of cytokines: increase the Тh1 activity and decrease the Т2 activity. Combined therapy found to be effective in the majority of AR patients. Сnclusion. Combined therapy with MF and DL in the treatment of perennial AR in children has clinical advan60
Russian Journal of Allergy. 2010;7(6):52-59
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FEATURES OF DIET THERAPY IN INFANTS WITH POLYVALENTFOOD ALLERGY
Pampura A.N., Varlamov E.E.
Abstract
Background. Establish indications for prescription of amino acid formula to infants with atopic dermatitis. Methods. 55 infants with atopic dermatitis and food allergy were enrolled. Allergic examination included skin prick tests and evaluation of specific IgE level. Oral challenge test was performed if necessary. Results. Low efficacy of elimination diet was observed in 16 infants with multiple food protein intolerance. In the issue cluster analysis defined two subgroups. High IgE levels, specific IgE to egg and fish were considered as criterions of the first subgroup. Patients with multiple food protein intolerance and low efficacy to elimination diet received amino acid formula, SCORAD index decreased more than 50% after the first week of treatment. Conclusion. Multiple food protein intolerance is particular form of food allergy. Prescription of amino acid formula is reasonable in this category of patients.
Russian Journal of Allergy. 2010;7(6):60-63
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SAFETY OF INTRANASAL CORTICOSTEROIDS
Kurbacheva O.M., Pavlova K.S.
Abstract
В статье рассмотрены факторы, влияющие на степень эффективности и безопасности, особенности фармакодинамики и фармакокинетики современных интраназальных глюкокортикостероидов (ИнГКС), в том числе нового для российского фармацевтического рынка ИнГКС - флутиказона фуроата.
Russian Journal of Allergy. 2010;7(6):64-68
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