ASSOCIATION OF IL5, CCL26 AND CCL5 GENE POLYMORPHISMSWITH ATOPIC BRONCHIAL ASTHMA



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Abstract

The purpose of the work. In order to investigate whether single nucleotide polymorphisms С(-703)Т in IL5
gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene contribute to atopic bronchial asthma development
we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian
patients from Moscow region.
Materials and methods. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donors
were genotyped.
Results. There were associations neither of С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5
gene with asthma nor with asthma severity.
Conclusion. Therefore, we may conclude that genes responsible for activation and chemotaxis of eosinophils play
an insignificant role in susceptibility to development of atopic bronchial asthma, and probably may influence
indirectly specific processes that occur in asthma.-

About the authors

O E Voronko

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

E V Dmitrieva-Zdorova

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

E A Latysheva

State Scientific Centre «Institute of Immunology» FMBA

State Scientific Centre «Institute of Immunology» FMBA

M G Aksenova

Institute for Human Ecology and Environmental Health

Institute for Human Ecology and Environmental Health

G I Storozhakov

Russian State Medical University

Russian State Medical University

N V Bodoev

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

Institute of Biomedical Chemistry of Russian Academy of Medical Sciences (IBMC RAMS)

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