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ALLERGIC DISEASES PRIMARY PREVENTION IN CHILDREN: POSITIVE PREDICTIVE VALUE AND HIGH SPECIFICITY OF INFORMATION ON ALLERGIC DISEASES IN MALE RELATIVES
- Authors: Treneva MS1
-
Affiliations:
- Federal state institution «oscow Science Research Institute of pediatrics and child surgery by Federalagency of advanced technology medical help» Russia
- Issue: Vol 7, No 6 (2010)
- Pages: 34-37
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/896
- DOI: https://doi.org/10.36691/RJA896
- ID: 896
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Abstract
Background. Сhildren allergic diseases primary prevention could be advanced with exploration of positive
predictive value (PPV), negative predictive value (NPV), sensitivity (Se) and specificity (Sp) of information on allergic diseases in a wide range of relatives.
Methods. retrospective analytic cross-sectional study. 1974 relatives of 212 children with allergic diseases and 137 controls were questioned. Couples of children equally aged were grouped in «×2»tables for each relativetype. Se was calculated as relative' allergic disease probability in child with allergic disease. Sp was calculated
as negative allergic disease relative' probability in negative allergic disease children. PPV was calculated as a probability of allergic diseased children in positive allergic disease relatives; NPV -as a probability of negative
allergic diseased children in negative allergic disease relatives.
Results. PPV was of high quantity in male relatives -father' father (86%), male cousins (80%), mother' father
(77%), mother' brother (73%), father of a child (72%). Mother' PPV was under 65%.
Sp of all relatives was of good quantity. The top levels belong to male relatives -father' father (97%), fathermother (94%), father' brother (91%), male cousins (91%), mother' brother (89%).
NPV of all relatives was useless for clinical practitioner.
Se was low in all relatives. Mother' Se was on top with 67%. So, male relatives'allergic disease importance is confirmed by high PPV and high Sp in grandfathers, uncles, male cousins.
Conclusion. high PPV and high Sp of information on allergic disease in male relatives combine prognostic valid
and specific risk criterion for allergic diseases in children. A child should be set for a primary prevention of allergic disease in case of allergic disease in grandfathers, or uncles, or male cousins, or child' father.
predictive value (PPV), negative predictive value (NPV), sensitivity (Se) and specificity (Sp) of information on allergic diseases in a wide range of relatives.
Methods. retrospective analytic cross-sectional study. 1974 relatives of 212 children with allergic diseases and 137 controls were questioned. Couples of children equally aged were grouped in «×2»tables for each relativetype. Se was calculated as relative' allergic disease probability in child with allergic disease. Sp was calculated
as negative allergic disease relative' probability in negative allergic disease children. PPV was calculated as a probability of allergic diseased children in positive allergic disease relatives; NPV -as a probability of negative
allergic diseased children in negative allergic disease relatives.
Results. PPV was of high quantity in male relatives -father' father (86%), male cousins (80%), mother' father
(77%), mother' brother (73%), father of a child (72%). Mother' PPV was under 65%.
Sp of all relatives was of good quantity. The top levels belong to male relatives -father' father (97%), fathermother (94%), father' brother (91%), male cousins (91%), mother' brother (89%).
NPV of all relatives was useless for clinical practitioner.
Se was low in all relatives. Mother' Se was on top with 67%. So, male relatives'allergic disease importance is confirmed by high PPV and high Sp in grandfathers, uncles, male cousins.
Conclusion. high PPV and high Sp of information on allergic disease in male relatives combine prognostic valid
and specific risk criterion for allergic diseases in children. A child should be set for a primary prevention of allergic disease in case of allergic disease in grandfathers, or uncles, or male cousins, or child' father.
About the authors
M S Treneva
Federal state institution «oscow Science Research Institute of pediatrics and child surgery by Federalagency of advanced technology medical help» RussiaFederal state institution «oscow Science Research Institute of pediatrics and child surgery by Federalagency of advanced technology medical help» Russia
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