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Vol 12, No 4 (2015)


Peculiarities of non-allergic rhinitis with eosinophilia syndrome

Utesheva V.A., Bondareva G.P., Kryukov A.I., Barkhina T.G.


Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.
Russian Journal of Allergy. 2015;12(4):3-7
pages 3-7 views

Immunologic reactivity and metabolic activity of blood lymphocytes associated with pathogenic form of allergic rhinosinusitis

Kolenchukova O.A., Smirnova S.V., Lapteva A.M.


We had studied functional and metabolic activity of blood lymphocytes in allergic rhinosinusitis (ARS) - atopic ARS and polypous rhinosinusitis (PRS). ARS is characterized by the increased level of CD25+ and HLA-DR+-lymphocytes in peripheral blood, IgA concentration in blood serum and sIgA in nasal secretion. At the same time the deviation of immune response is directed towards Th2-lymphocytes and is accompanied by high content of IL-4 and IL-6 in blood serum and nasal secretion. The activity of metabolic enzymes in blood lymphocytes in ARS is caused by exasperation of plastic processes, intensification of lipoid catabolism and increase of the speed of both anaerobic and aerobic oxidation. There are the following specific features of PRS: high level of CD19+-cells, activation of Thl-lymphocytes and high level of those cytokines, which they produce (IFN-γ and IL-2 in blood serum and nasal secretion). At the same time intensification of aerobic enzymes and lipoid metabolism and decreasing of anaerobic processes and aminoacid metabolism in blood lymphocytes are in the progress.
Russian Journal of Allergy. 2015;12(4):8-15
pages 8-15 views

Current strategies of allergen-specific immunotherapy

Pavlova K.S., Kurbacheva O.M.


The article discusses the principles of the optimal allergovaccine choice for allergen-specific immunotherapy (ASIT) for grass-pollen-allergy patients; reviewed efficacy and safety studies of the standardized mixt five-grass-pollen extract. Relatively grass sensitization is preferred use mixt grass-pollen extract is thus more suitable for specific immunotherapy, as it contains a broader repertoire of the epitopes, which approximate to the natural exposure conditions.
Russian Journal of Allergy. 2015;12(4):16-26
pages 16-26 views

Hereditary angioedema. Clinical recommendations for practitioners

Latisheva T.V., Latisheva E.A.
Russian Journal of Allergy. 2015;12(4):27-34
pages 27-34 views

The case of systemic mastocytosis in the practice of the allergist-immunologist

Khludova L.G., Myasnikova T.N., Romanova T.S., Latysheva T.V.


Mastocytosis is a disease caused by excessive proliferation of mast cells, and it can lead to anaphylactoid reactions. Different mechanisms are involving in the development of anaphylactoid and anaphylactic reactions, however, these reactions have a similar clinical picture. Therefore, patients with mastocytosis can get into the field of view of an allergist-immunologist with suspects insect, food, drug allergy or anaphylaxis of unknown origin. It’s important not only to suggest the correct diagnosis, but also to give the patient the recommendation to reduce the risk of life-threatening reactions. In this article the case of systemic mastocytosis without skin manifestations, which has been regarded for a long time by physicians as drug hypersensitivity is considered.
Russian Journal of Allergy. 2015;12(4):35-38
pages 35-38 views

The prevalence of allergy to fish in children in Tomsk region

Fedorova O.S., Ogorodova L.M., Fedotova M.M., Petrovskiy F.I., Evdokimova T.A., Balasheva I.I.


Objective. To investigate the prevalence and clinical manifestations of FA to fish in children in Tomsk region. Patients and methods. In the screening stage the crosssectional study based on screening questionnaires in random samples of children aged 7-10 years (n=13 010) was performed as a part of EuroPrevall project (EuroRrevall, № FP62006TTCTU5 Proposal 045 879). Those, who reported adverse reactions to food in the screening stage were considered as cases (n=652), children without reported reactions were controls (n=636). The casecontrol stage included the completion of a clinical questionnaire, skinprick test to fish (ALK Abellö, Spain), measurement of serum total and specific IgE to fish, componentresolved diagnostics: Cyp c 1, Gad m 1 (ImmunoCAP, ISAC, Phadia, Sweden). Results. The prevalence of verified FA to fish in children 7-10 years in the Tomsk region amounted to 0,32%; in urban children - 0,32%, in rural children - 0,31% (p=0,9). The main manifestations were skin symptoms, oral allergy syndrome, gastrointestinal symptoms. Anaphylactic shock developed in 15% of children with FA to fish. Conclusion. Fish is one of the main triggers of FA in children in Tomsk region, which leads to severe clinical manifestations , including lifethreatening conditions.
Russian Journal of Allergy. 2015;12(4):39-44
pages 39-44 views

The trained immunity phenomenon and mechanisms of action of non-specific immunomodifiers

Kalyuzhin O.V.


The discovery of the trained immunity phenomenon, which explains adaptive characteristics of the components of the innate immunity, not only to modernizes our understanding of the fundamentals of anti-infectious defense, but also contributes to further progress in the development and more rational selection and use of immunomodulatory agents. Induction of memory within the innate immune response is the basis of long-lasting immunomodulating effects of some non-specific immunomodifiers, which either contain ligands for innate immunity receptors or modulate the immune response pathway mediated by these receptors. For the first time, the mechanisms of action of pidotimod (a synthetic dipeptide with immunomodulatory properties) have been re-examined in the light of the trained immunity phenomenon.
Russian Journal of Allergy. 2015;12(4):45-51
pages 45-51 views

Bacterial lysates in prophylaxis of recurrent respiratory infections in children

Zaitseva O.V.


The best way to prevent recurrent respiratory infections in children considers the forming of adequate immune response against pathogenic bacteria. In this article efficacy and safety of bacterial lysate Broncho-Vaxome have been comprehensively reviewed.
Russian Journal of Allergy. 2015;12(4):52-59
pages 52-59 views

Modern allergology and clinical immunology - from laboratory analysis to clinical practice

Goudima G.O., Ilina N.I.
Russian Journal of Allergy. 2015;12(4):60-64
pages 60-64 views

Congresses, Conferences

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Russian Journal of Allergy. 2015;12(4):65-67
pages 65-67 views

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