Peculiarities of non-allergic rhinitis with eosinophilia syndrome

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Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.

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About the authors

V A Utesheva

L.I. Sverzgevsky Moscow Research and Practical Center of Otorhynolaryngology


G P Bondareva

Institute of Immunology

A I Kryukov

L.I. Sverzgevsky Moscow Research and Practical Center of Otorhynolaryngology

T G Barkhina

Institute of Human Morphology


  1. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization). Allergy. 2008, р. 8-160.
  2. Астафьева Н.Г., Удовиченко Е.Н., Гамова И.В. и соавт. Аллергический и неаллергический риниты: сравнительная характеристика. Леч. врач. 2013, № 4, с. 10.
  3. Scarupa M.D., Kaliner M.A. Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. World Allergy Organ J. 2009, v. 2, p. 20-25.
  4. Лопатин А.С. Ринит. Руководство для врачей. М., «Литерра». 2010, 417 с.
  5. Anne K. Ellis, Paul K. Keight. Nonallergic rhinitis with eosinofilia syndrome. Current allergy and asthma reports. 2006, v. 6, p. 215-220.
  6. Schiavino D., Nucera E., Milani A. et al. Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES). Allergy Asthma Proc. 1997, v. 18, p. 363-366.
  7. Jacobs R.L., Freedman P.M., Boswell R.N. Nonallergic rhinitis with eosinophilia (NARES syndrome). Clinical and immunologic presentation. J. Allergy Clin. Immunol. 1981, v. 67, p. 253-262.
  8. Rupp G.H., Friedman R.A. Eosinophilic nonallergic rhinitis in children. Pediatrics. 1982, v. 70, p. 437-439.
  9. Ненашева Н.М. Локальный аллергический ринит: миф или реальность? Эффективная фармакотерапия. Аллергология и иммунология. 2013, № 1, с. 13.
  10. Rondón C., Fernandez J., Canto G. et al. Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach. Esmon. Publicidad J. Investig. Allergol. Clin. Immunol. 2010, v. 20, p. 364-371.
  11. Swierczynska M., Strek P., Skladzien J. et al. Nonallergic rhinitis with eosinophilia syndrome: state of knowledge. Otolaryngol. Pol. 2003, v. 57, p. 81-84.
  12. Kramer M.F., Brow G.E. In vitro diagnosis of chronic nasal inflammation. Clin. Exp. Allergy. 2004, v. 34, p. 1086-1092.
  13. Gelardi M., Maselli del Giudice A., Fiorella M.L. et al. Non-allergic rhinitis with eosinophils and mast cells constitutes a new severe nasal disorder. Int. J. Immunopathol. Pharmacol. 2008, v. 2, p. 325-331.
  14. Gelardi M., Quaranta N., Passalacqua G. When sneezing indicates the cell type. Int. Forum Allergy Rhinol. 2013, v. 3, p. 393-398.
  15. De Corso E., Baroni S., Battista M. et al. Nasal fluid release of eotaxin-3 and eotaxin-2 in persistent sinonasal eosinophilic inflammation. Int. Forum Allergy Rhinol. 2014, v. 4, p. 617-624.
  16. Makihara S., Okano M., Fujiwara T. et al. Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis. Allergy Rhinol. (Providence.) 2014, v. 5, p. 22-27.
  17. Gröger M., Klemens C., Wendt S. et al. Mediators and cytokines in persistent allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome. Int. Arch. Allergy Immunol. 2012, v. 159, p. 71-78.
  18. Powe D.G., Groot Kormelink T., Sisson M. et al. Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis. J. Allergy Clin. Immunol. 2010, v. 125, p. 139-145.
  19. Milosevic D.N., Janosevic L.B., Janosevic S.B. Vasomotor skin tests in non-eosinophilic and eosinophilic long-term (perennial) nonallergic rhinitis. Srp. Arh. Celok. Lek. 2000, v. 128, p 84-89.
  20. Leone C., Teodoro C., Pelucchi A. et al. Bronchial responsiveness and airway inflammation in patients with nonallergic rhinitis with eosinophilia syndrome. J. Allergy Clin. Immunol. 1997, v. 100, p. 775-780.
  21. Moneret-Vautrin D.A., Hsieh V., Wayoff M. et al. Nonallergic rhinitis with eosinophilia syndrome a precursor of the triad: nasal polyposis, intrinsic asthma, and intolerance to aspirin. Ann. Allergy. 1990, v. 64, p. 513-518.
  22. Pinar E., Bolat A.F., Oncel I.S. et al. Computed tomography stage in patients with allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome. Kulak. Burun. Bogaz. Ihtis. Derg. 2004, v. 12, p. 1-5.
  23. Kramer M.F., de la Chaux R., Fintelmann R. et al. NARES: a risk factor for obstructive sleep apnea? Am. J. Otolaryngol. 2004, v. 25, p. 173-177.
  24. Cassano M., Cassano P., Mora F. et al. Nares patients have more respiratory infections than allergic subjects. Ann. Allergy Asthma Immunol. 2007, v. 99, p. 232-235.
  25. Webb D.R., Meltzer E.O., Finn A.F. et al. Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann. Allergy Asthma Immunol. 2002, v. 88, p. 385-390.
  26. Shahab R., Phillips D.E., Jones A.S. Prostaglandins, leukotrienes and perennial rhinitis. Kulak. Burun. Bogaz. Ihtis. Derg. 2004, v. 12, p. 1-5.
  27. Purello-D’Ambrosso F., Isola S., Ricciardi L. et al. A controlled study on the effectiveness of loratadine in combination with flunisolide in the treatment of nonallergic rhinitis with eosinophilia (NARES). Clinical and Experimental Allergy. 1999, v. 29, p. 1143-1147.

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