Vol 11, No 4 (2014)

The review presents the data on mechanical vibration and two types of non-ionizing radiation influence on im- munological reactivity of the organism. Mechanical vibration causes a cell immunity suppression and immuno- pathological syndromes development. li EMr activates t-lymphocytes and increases expression of il-1b, iFn-g and tnFa genes which determine anti-inflammatory effect. li lr has hormesis effect: it`s small doses activate immunocyte and cytokine production and it`s high doses lead to immunosuppression.

Background. To investigate the drug’s hypersensitivity reactions occuring during perioperative period in central clinical hospital of the russian academy of sciences during 2010-2012 years. The article proposes the introduction of the special questionnaire for perioperative anaphylactic risk assessment. Materials and methods. We compiled a questionnaire for perioperative drug hypersensitivity risk assessment. The questionnaire built up by recording the individual scores related to the most relevant anaphylaxis parameters (i. e. medical history, symptoms and medication for asthma, rhinitis and urticaria etc.) and by adding them on all together; consists of 2 parts: questions in part 1 correspond to the doctor, questions in part 2 - to the patient. Based on the results of the questionnaire, the risk of drug’s hypersensitivity reactions was estimated as low, me- dium, high or very high. We performed retrospective questionnaire survey using special questionnaire of 3240 allergic patients [2398 (74%) women, 842 (26%) man - aged between 18-85 years old (50,3±0,3)] in preoperative period in central clinical hospital of the russian academy of sciences during 2010-2012. The control group consisted of 20 healthy respondents, those with no medical education. all reviewed patients had anesthesia and surgical interventions, 23 of them (13 women, 10 men aged between 22-84 years old) showed drug’s hypersen- sitivity reactions during early postoperative period. Results. all respondents noted clarity and concreteness of the items of the questionnaire. reproducible answers amounted to 95%. We detected the increase of the resulting frequency of the perioperative drug hypersensiti- vity in patients with increasing number of scores. The questionnaire was able to distinguish patients with risk of perioperative drug hypersensitivity reactions (known-group validity). identified significant differences in rates of patients with allergic diseases and practically healthy persons (p< 0,001). Conclusion. The questionnaire is a reliable, valid, and sensitive tool for screening patients at risk of perioperative drug’s hypersensitivity reactions. The questionnaire could be used in the perioperative period to evaluate the anaphylactic risk and to prescribe risk-oriented premedication protocols.

Background. To investigate the content of breast milk a-lactalbumin in urine of infants and the intestinal bio- cenosis for estimation of permeability of the intestinal barrier and the development of food allergies. Materials and methods. 61 breast-fed infants aged 7 to 10 days, 33 boys and 28 girls were included in the study. They level of urinary excretion of a-lactalbumin of breast milk in the urine by elisa with a modification as well as the intestinal microflora by a bacteriological method were determined. Results. it was established, that excretion rate of breast milk a-lactalbumin in the urine of infants varied in a wide range of values from traces quantities to 300,0 ng/ml. depending on the content of a-lactalbumin in the urine infants were divided into 2 groups: first (n=52) with low levels of excretion of a-lactalbumin ranging from trace values (<0, 9 нг/ml) up to 40,0 ng/ml (mean value is 7,87+1,32 ng/ml; the second group (n=9) with high excretion of a-lactalbumin from 40,0 to 300,0 ng/ml (mean 111,54+9,12 ng/ml). familial predisposition to al- lergic diseases more often met in children with high excretion of a-lactalbumin in urine and increased content of S. aureus in stools. Conclusion. abnormally increased urinary excretion of alphalactalbumin, as defined in the first days of life, and the risk of subsequent food sensitization have been obtained. The risk of sensitization in these infants is higher when family allergic predisposition and incresed level of S. aureus in the intestinal microflora occur. These results demonstrate the expedience of urinary excretion of breast milk a-lactalbumin testing in newborns for detecting of infants with high risk for development of food intolerance.

Background. To Evaluate the effects of trees pollen sublingual products on the control and quality of life in patients with allergic asthma and proven sensitization to pollens of trees. Methods. We enrolled 56 patients in open prospective study and divided into 2 groups to assess the effectiveness of therapy with sublingual allergen. Groups were matched on estimated parameters of quality of life, level of control and forced expiratory volume in the first second. Results. Statistically significant improvement of quality of life parameters and the level of control within the group receiving sublingual immunotherapy was obtained. Significant difference in the average dose of received inhaled corticosteroids was established in the treatment group comparing to control. Conclusion. Sublingual allergen specific immunotherapy has a positive impact on quality of life and level of control in patients with allergic asthma and proven sensitization to pollens of trees, and decreasing the dose of inhaled corticosteroids.

Background. Structural and functional damages of the epidermal barrier in patients with atopic dermatitis promote the entry of allergens and development of Th2-type allergic inflammation. Moisturizers containing lipids increase the physiological antiinflammatory effects of topical corticosteroids (TGKS), improve the epidermal barrier and reduce the duration of TGKS using preventing further infringement barrier. To evaluate the clinical efficacy of emollient milk Xemose in children with atopic dermatitis. Materials and methods. We examined 27 children with atopic dermatitis. Children were divided into 2 groups: patients in group 1 (n=14) used emollient milk Xemose twice a day on the skin lesions and limbs in the complex therapy, patients in the 2nd group (n=13) received combined therapy incorporating traditional dampening agents on the basis of lanolin (Unna cream) 3 times daily. All patients underwent measurement of transepidermal water loss (TEWl) (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (Skin-pH-Meter, Multi Probe Adapter MPA 5/9, Courage + Khazaka) before and after 2 weeks of therapy. Results. Patients in groupthat used Xemose milk and children in group with Unna cream after 2 weeks showed a statistically significant decrease of TEWl (p=0,041 and p=0,04, respectively). TEWl was significantly lower in children treated for 2 weeks with milk Xemose (p=0,027) than in children treated with Unna cream. in both groups pH skin surface have not changed (р=0,22 and р=0,22 respectively). Conclusion. Clinical efficacy of milk Xemose as compound improving skin barrier function in children with atopic dermatitis was shown.