THE RISK OF FOOD INTOLERANCE IN INFANTS WITH INCREASED URINARY EXCRETION OF BREAST MILK ALPHA-LACTALBUMIN

Background. To investigate the content of breast milk a-lactalbumin in urine of infants and the intestinal bio- cenosis for estimation of permeability of the intestinal barrier and the development of food allergies. Materials and methods. 61 breast-fed infants aged 7 to 10 days, 33 boys and 28 girls were included in the study. They level of urinary excretion of a-lactalbumin of breast milk in the urine by elisa with a modification as well as the intestinal microflora by a bacteriological method were determined. Results. it was established, that excretion rate of breast milk a-lactalbumin in the urine of infants varied in a wide range of values from traces quantities to 300,0 ng/ml. depending on the content of a-lactalbumin in the urine infants were divided into 2 groups: first (n=52) with low levels of excretion of a-lactalbumin ranging from trace values (<0, 9 нг/ml) up to 40,0 ng/ml (mean value is 7,87+1,32 ng/ml; the second group (n=9) with high excretion of a-lactalbumin from 40,0 to 300,0 ng/ml (mean 111,54+9,12 ng/ml). familial predisposition to al- lergic diseases more often met in children with high excretion of a-lactalbumin in urine and increased content of S. aureus in stools. Conclusion. abnormally increased urinary excretion of alphalactalbumin, as defined in the first days of life, and the risk of subsequent food sensitization have been obtained. The risk of sensitization in these infants is higher when family allergic predisposition and incresed level of S. aureus in the intestinal microflora occur. These results demonstrate the expedience of urinary excretion of breast milk a-lactalbumin testing in newborns for detecting of infants with high risk for development of food intolerance.

food allergy, infants, a-lactalbumin of breast milk, urine