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Vol 11, No 1 (2014)

Articles
Editorial
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Russian Journal of Allergy. 2014;11(1):3-4
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Academician Rakhim Musaevich Khaitov (70th Anniversary)
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Russian Journal of Allergy. 2014;11(1):5-6
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Allergic reactivity - evolutionary attainments by highly organized animals
Gushchin I.S.
Abstract
The paper has given an insight of allergy as evolutionary selected reactivity for highly organized animals. This reactivity is directed to organization of allergen-specific inflammation and serves as biologically expedient, high-specific and high-sensitive reaction in response to allergen entering into the organism because of barrier tissue dysfunction (higher allergen permeability). such insight has raised a question on consequences of allergy reactivity elimination for highly organized animals and their posterity.
Russian Journal of Allergy. 2014;11(1):7-16
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Skin care as a way to recover microbiome in patients with atopic dermatitis
Pavlova K.S.
Abstract
Recently microbiome of the skin was characterized using genomic technologies in norm and in pathology. Microbiome of the affected skin in atopic dermatitis is characterized by a lack of the variety of bacteria, decrease of the Actinomycetes and Proteobacteries species and increase of Staphylococci colonization (Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus and others). Restoration of the skin barrier function is the most important goal in the overall concept of the atopic dermatitis treatment. Recent studies demonstrated the possibility of reductionof inflammation, xerosis, itching and restoration of skin microbiome of the affected areas by emollients use (Lipikar Baume AP, La Roche Posay), as a result of the skin barrier function improvement.
Russian Journal of Allergy. 2014;11(1):17-22
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Experience of antihistamines using in atopic dermatitis adults
Tuzlukova E.B.
Abstract
The published data about using of the 1 st and 2 nd generation antihistamines in the treatment of atopic dermatitis are reviewed in this article. The own data of the morbidity and clinical features of atopic dermatitis in adults, the effectiveness of complex therapy including 1 st and 2 nd generation antihistamines in patients are presented.
Russian Journal of Allergy. 2014;11(1):23-32
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The influence of subcutaneous allergen-specific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis: 2-years follow-up results
Shakhova N.V., Lobanov U.F., Gordeev V.V., Tokarev V.P., Surkova M.V.
Abstract
Background. The purpose of the study was to investigate the influence of subcutaneous allergenspecific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis Methods. 50 patients at the age from 5 to17 years old with allergic rhinoconjunctivitis sensitized to trees pollen (birch, alder, hazel) were observed. All the patients were divided into 2 groups. The first group consisted of 23 children, who were treated with birch extract («Phostal») subcutaneous allergen-specific immunotherapy (SCIT). The second group was a control group, consisted of 27 children, no treatment was assigned to them. Results. Statistically significant increase of all quality of life indexes in the group which was treated with SCIT using «Phostal» was observed. Statistically valid decrease of severity of rhinoconjunctivitis symptoms in the 1 group was shown (6,1±3,1; 11,8±4,5; p=0,00002). Total number of Phostal injections was 990, 227 (23%) local reactions and no one systemic reaction have been observed during the study. Conclusion. SCIT with birch extract absorbed onto calcium phosphate could be considered as a highly effective and safe method of treatment of pollinosis in children.
Russian Journal of Allergy. 2014;11(1):33-38
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Polymorphism in genes encoding xenobiotic-metabolizing enzymes (GSTM1 and GSTT1) and the risk of asthma onset in Moldovan and other ethnic groups: a meta-analysis
Vasilos L.V., Kyrstya O.N., Ivashchenko T.E., Kozhokaru A.N., Aseyev M.V., Arama M.G., Horodishtyanu-Banuh A.I., Savoskina D.V.
Abstract
Background. The aim of the study was to examine the association of the risk of asthma onset with polymorphisms in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1) in Moldovans and other ethnic groups using the meta-analysis method. Methods. A meta-analysis of the association of genetic polymorphism of GSTT1 and GSTM1 genes and the risk of asthma development in 180 Moldovan subjects in comparison with published data on various ethnogeographical affiliations was performed. Results. The meta-analysis results were based on sixteen studies which included a total number of 3873 patients and 4863 healthy individuals. The meta-analysis showed an increased risk of disease development in subjects who are carriers of the GSTM1 null genotype (odds ratio of the cumulative risk was 1,29; 95% CI 1,09-1,54), whereas the GSTT1 0/0 genotype was associated with a 1,32 fold increase of the cumulative risk of asthma onset (95% CI 0,99-1,75). Conclusion. The obtained results suggest that the risk of asthma development is associated with the deletion polymorphism in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1), but the mechanisms of the disease also depend on the gene-by-gene and gene-environment interactions.
Russian Journal of Allergy. 2014;11(1):39-44
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Drug allergy. Recommendations for clinicians (Part 3)
Ilina N.I., Latisheva T.V., Miasnikova T.N., Luss L.V., Kurbacheva O.M., Erokhina S.M.
Abstract
Recommendations contain modern data about incidence, etiology, patogenesis, diagnostics and treatment of drug allergy.
Russian Journal of Allergy. 2014;11(1):45-52
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Anaphylactic reactions to hymenoptera sting - situation in Kazan city and existing problems
Fassakhov R.S., Reshetnikova I.D., Safina L.F.
Abstract
Background. The aim of this study was to estimate the prevalence rate of severe allergic reactions to hymenoptera sting according to data, gathered by specialized allergological department of Kazan hospital No. 7 in 2000-2011. Materials and Methods. 493 patients hospitalized during the period of 2000-2011 with anaphylactic shock (ASh) including 133 patients with ASh to Hymenoptera sting were analised. Results. The study showed a high frequency of ASh developed as a result of hymenoptera sting comparing with total cases of ASh hospitalizations (27%, Cl: 23-31%). In most ASh cases was caused by wasps stings (52%, Cl: 43-60%). Male patients are supposed to be more vulnerable to the risk of stings (58%, Cl: 50-66%). More often ASh showed acute cardiovascular symptoms (79,7%, Cl: 72-85%). Emergency crews used epinefrine in order to relieve ASh only in 30% of cases (30%, Cl: 22-38%). Conclusion. Systemic allergic reactions to Hymenoptera sting prevalence shows the need for registration of allergens for immunotherapy and injection pen with epinefrine for selfhelp in case of ASh development with in the territory of Russian Federation.
Russian Journal of Allergy. 2014;11(1):53-58
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Allergic rhinitis or adenoid vegetations/adenoids. Where is the truth?
Revyakina V.A., Garaschenko T.I., Samohvat A.M.
Abstract
Background. Children with frequent acute respiratory viral infections and clinical symptoms of the upper respiratory tract are often prescribed unwarranted surgical treatment. The aim of this study was to assess the allergic reactivity in children with frequent acute respiratory viral infections and obstructed nasal breathing. Methods. The study included 48 children aged from 2 to 7 years old, 29 boys and 19 girls. Clinical examination including anamnesis morby and family anamnesis of allergy, endoscopic examination of the nose and nasopharynx, total and allergen-specific IgE determination were performed. Results. In 87,5% of children with frequent acute respiratory viral infections and previously diagnosed adenoid hypertrophy degree II-III with a block of auditory tube pharyngeal mouths or hypertrophy of adenoid hypertrophy with II degree pipe rollers, pipe tonsils, allergic rhinitis (?) hypersensitivity to house dust mites and in 54,1% to pollen was detected. In 25,0% of children allergen-specific IgE antibodies to food allergens (cow’s milk, nuts, grains, pears) were identified. 33,3% of children had high levels of allergen-specific IgE antibodies to cats and dogs epidermidis. Conclusion. Children with frequent acute respiratory viral infections and nasal obstruction require allergist survey to develop treatment strategies.
Russian Journal of Allergy. 2014;11(1):59-63
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Sensitive skin care with Sensidiane® line cosmetics
Elisyutina O.G., Styrbul O.V., Zemskaya E.N.
Abstract
In article the data on clinical efficacy of the cosmetic line Sensidiane ®, Noreva Laboratories, France, in sensitive skin care of patients with various diseases: rosacea, seborrheic dermatitis, atopic dermatitis are presented.
Russian Journal of Allergy. 2014;11(1):64-68
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Treatment of itch in allergic dermatoses
Perlamutrov Y.N., Olkhovskaya K.B.
Abstract
Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.
Russian Journal of Allergy. 2014;11(1):69-72
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Allergic contact dermatitis
Kochergin N.G.
Abstract
Russian Dermatology describes irritant and allergic contact dermatitis. The latter one being immune associated is characterized by huge spectrum of clinical features demanding individual approaches to topical corticosteroid therapy. Hydrocortizone 17-butirate in the formulations of ointment, cream, Lipocream and Crelo allows effectively and safely solve therapeutic problems of topical treatment.
Russian Journal of Allergy. 2014;11(1):73-79
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Evaluation of the effectiveness of diet therapy in infants with gastrointestinal manifestations of food allergy
Sentsova T.B., Kirillova O.O., Vorozhko I.V., Revyakina V.A., Monosova O.Y., Denisova S.N., Belitskaya M.Y., Timopheeva A.M., Myagkova M.N.
Abstract
Background. The aim of the study was to evaluate the effectiveness of the diet therapy in infants with gastrointestinal manifestations of food allergy to cow’s milk protein. Materials and methods. 126 bottlefed infants aged from 1 to 12 months were examined for mucosal immunity and bowel microbiota parameters. Results. The changes of intestinal microbiota with in creased of conditionally pathogenic species (Klebsiella, Proteus, Citrobacter spp., etc.) with normal rates of anaerobic bacteria (bifido- and lactobacilli spp.) were revealed. sIgA levels in coprofiltrates in infants with gastrointestinal manifestations of food allergy were significantly reduced compared with the control group. Elevated C-reactive protein (CRP) levels compared with healthy children were obtained. Elevated levels of total IgE as well as allergen-specific IgE to cow’s milk proteins incoprofiltrates were estimated being the evidence of food sensitization. Using of adapted formulas based on the New Zealand goat milk with a complex of prebiotics in infants with gastrointestinal manifestations of food allergy led to normalization of intestinal microflora with reducing of Enterobacteriaceae spp. colonization. Positive changes in mucosal immunity were observed: increase of sIgA levels, decrease of total and allergen-specific IgE and CRP levels in coprofiltrates. Conclusion. The study demonstrated the usefulness of adapted formulas based on the New Zealand goat milk with a complex of prebiotics as diet therapy in infants with gastrointestinal manifestations of food allergy.
Russian Journal of Allergy. 2014;11(1):80-84
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Informational Letter
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Russian Journal of Allergy. 2014;11(1):85-87
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Congresses, Conferences
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Russian Journal of Allergy. 2014;11(1):88-88
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