Treatment of itch in allergic dermatoses
- Authors: Perlamutrov YN1, Olkhovskaya KB1
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Affiliations:
- Moscow State University of Medicine & Dentistry
- Issue: Vol 11, No 1 (2014)
- Pages: 69-72
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2014
- URL: https://rusalljournal.ru/raj/article/view/571
- DOI: https://doi.org/10.36691/RJA571
- ID: 571
Cite item
Abstract
Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.
Keywords
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About the authors
Y N Perlamutrov
Moscow State University of Medicine & Dentistry
K B Olkhovskaya
Moscow State University of Medicine & Dentistry
Email: olhovskaya_kira@mail.ru
References
- Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta Derm. Venerol. Suppl. (Stockh.). 1980, v. 92, p. 44-47.
- Koblenzer C.S. Itching and the atopic skin. J. Allergy Clin. Immunol. 1999, v. 104 (3 Pt. 2), p. 109-113.
- Von Frey M. On the physiology of pruritus. Arch. Neerland Physiol. 1922, v. 7, p. 142-145.
- Paus R., Schmelz M., Biro T., Steinhoff M. Frontiers in pruritus research: scratching the brain for more effective itch therapy. J. Clin. Invest. 2006, v. 116, p. 1174-1186.
- Handwerker H.O., Schmelz M. Pain: itch without pain-a labeled line for itch sensation? Nat. Rev. Neurol. 2009, v. 5, p. 640-641.
- Супрун Е.Н., Разина Л.А. Зуд при патологии внутренних органов. Аллергол. и иммунопатол. в педиатрии. 2012, № 2, с. 29-36.
- Болотная Л.А. Место антигистаминных препаратов в терапии зудящих дерматозов аллергического генеза. Укр. журн. дерматол., венерол., косметол. 2010, № 2, с. 29-34.
- Buddenkotte J., Steinhoff M. Pathophysiology and therapy of pruritus in allergic and atopic diseases. Allergy. 2010, v. 65, p. 805-821.
- Galli S.J. Mast cells in the development of adaptive immune responses. Nat. Immunol. 2005, v. 6, p. 135-142.
- Мурашкин Н.Н., Глузмин М.И., Материкин А.И. Оценка эффективности антигистаминных лекарственных препаратов в комплексной терапии зудящих дерматозов с хроническим течением. Вестн. дерматол. и венерол. 2011, № 4, с. 84-87.
- Lewis T The blood vessels of the human skin and their responses. London: Shaw and Sons. 1927, р. 21-80.
- Lewis T., Grant R.T., Marvin H.M. Vascular reactions of the skin to injury. Heart. 1929, v. 14, p. 139-160.
- Williams D.H. Skin temperature reaction to histamine in atopic dermatitis (disseminated neurodermatitis). J. Invest. Dermatol. 1938, v. 1, p. 119-129.
- Haas H.L., Sergeeva O.A., Selbach O. Histamine in the nervous system. Physiol. Rev. 2008, v. 88, p. 1183-1241.
- Ревякина В.А. Антигистаминные препараты в практике поликлинического врача. Леч. врач. 2011, № 4, с. 13-16.
- Heyer G., Hornstein O.P., Handwerker H.O. Reactions to intradermally injected substance P and topically applied mustard oil in atopic dermatitis patients. Acta Derm. Venerol. 1991, v. 71, p. 291-295.
- Коган Б.Г., Терлецкий В.Б., Терлецкий Р.В. Современная терапия аллергических дерматозов. Вересень. 2005, № 3, с. 22-24.
- Ласица О.И., Яковлева Н.Ю., Леуш В.Т Опыт применения препарата Фенистил у детей с аллергодерматозами Совр. педиатр. 2004, № 2 (3), с. 61-64.
- Данилова А.А. Общие подходы к терапии экземы в практике врача-интерниста. Леч. врач. 2011, № 8, с. 94-97.
- Катона М., Терек Е. Применение диметиндена малеата при различных зудящих заболеваниях кожи в детском возрасте. Леч. врач. 2011, № 4, с. 86-87.
- Rehn D., Geissler H., Schönbrunn U. et al. Effect-time relation of the H1-receptor antagonist dimethindene maleafe following intravenous injection. Agents and Actions. 1990, v. 30, p. 178-181.
- Schaffler K., Beckers C., Unkauf M., Kyrein H. Dimethindene Maleate in the treatment of sunburn. Arzneimittelforschung. 1999, v. 49 (4), p. 374-379.
- Church M., Church D. Pharmacology of antihistamines. Indian J. Dermatol. 2013, v. 58, p. 219-222.
- Kirchhoff C.H., Kremer B., Haaf-von Below S. et al. Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Rhinology. 2003, v. 41, p. 159-166.