Email this article 
The influence of subcutaneous allergen-specific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis: 2-years follow-up results
- Authors: Shakhova NV1, Lobanov UF1, Gordeev VV1, Tokarev VP2, Surkova MV2
-
Affiliations:
- Altai State Medical University
- Children’s clinical hospital № 7
- Issue: Vol 11, No 1 (2014)
- Pages: 33-38
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2014
- URL: https://rusalljournal.ru/raj/article/view/539
- DOI: https://doi.org/10.36691/RJA539
- ID: 539
Cite item
Open Access
Access granted
Abstract
Background. The purpose of the study was to investigate the influence of subcutaneous allergenspecific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis Methods. 50 patients at the age from 5 to17 years old with allergic rhinoconjunctivitis sensitized to trees pollen (birch, alder, hazel) were observed. All the patients were divided into 2 groups. The first group consisted of 23 children, who were treated with birch extract («Phostal») subcutaneous allergen-specific immunotherapy (SCIT). The second group was a control group, consisted of 27 children, no treatment was assigned to them. Results. Statistically significant increase of all quality of life indexes in the group which was treated with SCIT using «Phostal» was observed. Statistically valid decrease of severity of rhinoconjunctivitis symptoms in the 1 group was shown (6,1±3,1; 11,8±4,5; p=0,00002). Total number of Phostal injections was 990, 227 (23%) local reactions and no one systemic reaction have been observed during the study. Conclusion. SCIT with birch extract absorbed onto calcium phosphate could be considered as a highly effective and safe method of treatment of pollinosis in children.
Full Text
About the authors
N V Shakhova
Altai State Medical University
Email: Natalia.shakhova@mail.ru
Barnaul
U F Lobanov
Altai State Medical UniversityBarnaul
V V Gordeev
Altai State Medical UniversityBarnaul
V P Tokarev
Children’s clinical hospital № 7Barnaul
M V Surkova
Children’s clinical hospital № 7Barnaul
References
- Dahi R., Andersen P.S., Chivato T. National prevalence of respiratory allergic disorders. Respir. Med. 2004, v. 98, p. 398-403.
- Bauchau V., Durham S.R. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur. Respir. J. 2004, v. 24, p. 758-764.
- Bousquet J., Bullinger M., Fayol C. et al. Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Station Questionnaire. J. Allergy Clin. Immunol. 1994, v. 94, p. 182-188.
- Leynaert B., Neukirch C., Liard R. et al. Quality of life in allergic rhinitis and asthma: A population-based study of young adults. J. Respir. Crit. Care Med. 2000, v. 162, p. 1391-1396.
- Storms W.W. Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis. J. Allergy Clin. Immunol. 2004, v. 114 (Suppl), p. 146-S153.
- Stuck B.A., Czaikowski J., Hagner A.E. et al. Changes in daytime sleepiness, quality of life and objective sleep patterns in seasonal allergic rhinitis: A controlled clinical trial. J. Allergy Clin. Immunol. 2004, v. 113, p. 663-668.
- Marshall P.S., Colon E.A. Effect of allergy season on mood and cognitive function. Ann. Allergy. 1993, v. 71, p. 251-258.
- Гущин И.С., Курбачева О.М. Аллергия и аллергенспецифическая иммунотерапия. И.С. Гущин, О.М. Курбачева.-М. 2010, 227 с.
- Abramson M., Puy R., Weiner J. Immunotherapy in asthma: an updated systematic review. Allergy. 1999, v. 54, p. 1022-1041.
- Malling H.J. Allergen immunotherapy efficacy in rhinitis and asthma. Allergy Clin. Immunol. Int. J. World Allergy Org. 2004, v. 16 (3), p. 92-95.
- Курбачева О.М. Аллерген-специфическая иммунотерапия. Рос. Аллергол. Журн. 2004, № 2, с. 32-54.
- Moller C., Dreborg S., Ferdousi H.A. et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-stady). J. Allergy. Clin. Immunol. 2002, v. 109, p. 251-256.
- Kumar P., Kamboj S., Rao P. et al. The cost of care and quality of life in patients with allergic rhinitis on allergen immunotherapy. J. Allergy. Clin. Immun. Intern. 1997, v. 9 (5), p. 133-135.
- Yilmaz M., Bingol G., Altindas D. et al. Effect of SIT on quality of life. Allergy. 2000, v. 55, p. 302-309.
- Standards for practical allergen-specific immunotherapy. Allergy. 2006, v. 61, Suppl. 82, p. 1-20.
- Botey J., Cadahia A., Cobo R. et al. Tolerancia de la immunoterapia especifica con extractos alergenicos adsorbidos sobre fostato de calico. Rev. Esp. Alergolo Immunol. Clin. 1997, v. 12, p. 45-50.
- Donat N., Thibaudon M., Peltre G. et al. Desensibilisation par des extraits de pollen adsorbes sur phosphate de calcium pedant 4 annes consecutives: etud des serum par immunoempreintes. Rev. Esp. Alergolo Immunol. Clin. 1998, v. 36, p. 33-40.
- Fadel R., Andre C., Bellanger M. et al. Tolerans, compliance et efficacite de immunotherapia specifique par des extraits allergeniques aqueus ou adsorbes sur phosphate de calcium. Etude retrospective. Rev. Fr. Allergol. 1998, v. 38, p. 41-49.
- Курбачева О.М., Павлова К.С., Ильина Н.И. и соавт. Эффективность проведения аллерген-специфической иммунотерапии препаратом «Фосталь» у больных поллинозом. Рос. Аллергол. Журн. 2009, № 3, с. 27-31.
- Мокроносова М.А., Коровкина Е.С. Аллергенспецифическая иммунотерапия аллергенным экстрактом пыльцы деревьев, адсорбированным на суспензии кальция фосфата. Рос. Аллергол. Журн. 2010, № 4, с. 79-84.
- Шахова Н.В., Гордеев В.В., Харченко С.С. и соавт. Опыт проведения подкожной аллерген-специфической иммунотерапии препаратом «Фосталь» при поллинозе у детей. Рос. Аллергол. Журн. 2011, № 6, с. 79-84.
- Шахова Н.В., Гордеев В.В., Токарев В.П. и соавт. Влияние подкожной аллерген-специфической иммунотерапии на качество жизни детей с сезонным аллергическим риноконъюнктивитом. Мать и дитя в Кузбассе. 2012, № 3 (50), с. 37-41.
- Шахова Н.В., Гордеев В.В., Токарев В.П. и соавт. Побочные эффекты и комплаенс при проведении аллерген-специфической иммунотерапии экстрактом аллергенов пыльцы деревьев, адсорбированным на суспензии кальция фосфата. Рос. Аллергол. Журн. 2012, № 6, с. 44-48.
- Шахова Н.В., Гордеев В.В., Лобанов Ю.Ф. и соавт. Побочные эффекты аллерген-специфической иммунотерапии экстрактом аллергенов пыльцы деревьев, адсорбированным на суспензии кальция фосфата. Мать и дитя в Кузбассе. 2013, № 1 (52), с. 50-54.
Supplementary files
