Vol 11, No 3 (2014)

Food allergies (fa), defined as an adverse immune response to food proteins, effect up to 3-5% of the popula- tion in westernized countries, and their prevalence appears to be rising. a variety of mechanisms underlie the allergic reactions, not all of them run through the IgE sensitisation. the absence of sIgE in peripheral circulation characterize a group of non-Ig-Emediated disorders, such as food protein-induced enterocolitis, enteropathy and prococolitis. In case of eosinophilic esophagitis, gastritis and enterocolitis IgE sensitization arises in nearly 50%, therefore these disorders are classified as mixed-type. In some cases of gastrointestinal fa local IgE production, when switching to IgE synthesis occurs only in one organ, have been proved. although systemic investigation of this phenomenon is still lacking. Immune inflammation coursed by food allergens can involve nearly all organs and systems. this review focuses on gastroenterological manifestations of food allergy, except of broad field of gluten intolerance that demands a separate thorough reviewing.

Modern approaches to topical treatment of atopic dermatitis (ad) are presented in the review. the application of different proactive therapy patterns like topical corticosteroids intermittent treatment and topical calcineurin inhibitors as antirecurrent therapy of ad patients are discussed.

Epidermal barrier insufficiency results in skin dryness and fissures in different chronic dermatoses. Barrier dysfunction is due either to genetic problems or lipid deficiency or damage of tight junction proteins. Here we discuss various abnormalities of epidermal barrier in eczema and psoriasis which necessitate to prescribe pro- tective and moisturizing agents to restore skin barrier. We give our own practice data of using Bariederm cream and balm in combined therapy of dyshidrotic eczema, plantar eczema and palmoplantar psoriasis.

Efficacy of the allergen immunotherapy (ait) in the treatment of allergic rhinitis and asthma has been proved in many studies and systematic reviews. Higher safety profile of sublingual ait (slit) relative subcutaneous ait (sCit) defines preferences of slit. although the results of the first study of slit were published about 25 years ago and a lot of allergenic products for slit appeared during this period, poor evidence base and a lack of direct comparative controlled studies on the efficacy of slit vs sCit support debate about what way of allergen administration is more effective. it is possible, that lower efficacy of slit showed in earlier studies explains for the use of regimes with low daily and cours doses of allergens. in a recent review of the eaaCi it was shown the dosedependent therapeutic effect of ait, and was noted that an increase of the maintenance allergen dose while sCit increases the risk of adverse events, vs high doses slit demonstrates good safety profile with a significant increase of efficacy. it is possible that future studies using high doses of standardized allergens for slit will show not only more high profile of slit safety, but also its higher efficacy vs sCit.

The review presents the results of various studying of basic properties of azoximeri bromidum (polyoxidonium). The experience of application of immunomodulator in patients with respiratory diseases was analyzed. polyoxidonium has expressed immunomodulatory activity (including interferonproducing), has nonspecific protective effect against a broad range of pathogens that are not based on direct inhibition of microorganisms, and on the regulation of immune function. in addition, the drug has antitoxic and antioxidant properties. in the acute period of the disease polyoxidonium is recommended to prescribe in combination with etiotropic therapy and during rehabilitation or prevention of infectious diseases as monotherapy.