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APPLICATION OF SERTACONAZOLE FOR SUPERFICIAL MYCOSES COMPLICATED BY BACTERIAL INFECTION
- Authors: KHAMAGANOVA IV1, KASHEVAROV DF1
-
Affiliations:
- Russian national research medical university named after N.I. Pirogov
- Issue: Vol 11, No 3 (2014)
- Pages: 68-72
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/532
- DOI: https://doi.org/10.36691/RJA532
- ID: 532
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Abstract
Sertaconazole properties are discussed in the article. According to literature data application of the derivation of benzotiafene and imidazole solves a problem of resistance towards antimycotics. Sertaconazole has a wide spectrum of activity towards fungi & bacteria and also has antiinflammatory effect. The present examination of therapeutic efficacy included 33 patients who suffered from superficial mycoses complicated by bacterial infection. Levocetirizine was prescribed in case of dermatomikides. Both monotherapy by sertaconazole and combination with levocetirizine were high effective and well tolerable.
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About the authors
I V KHAMAGANOVA
Russian national research medical university named after N.I. Pirogov
Email: clinderm11@gmail.com
Department of skin diseases & cosmetology Moscow
D F KASHEVAROV
Russian national research medical university named after N.I. PirogovDepartment of skin diseases & cosmetology Moscow
References
- Хамаганова И.В., Карамова А.Э., Шекрота А.Г., Макуши- на З.В. Применение сертаконазола в лечении микроспо- рии гладкой кожи. Клин. дерматол. и венерол. 2010, № 3, с. 32-36.
- Соколова Т.В., Малярчук А.П., Малярчук Т.А. Результаты многоцентрового исследования по изучению поверхност- ных микозов кожи в регионах Российской Федерации и оценке эффективности их лечения сертаконазолом. Клин. дерматол. и венерол. 2013, № 5, с. 28-38.
- Сергеев А.Ю., Сергеев Ю.В. Грибковые инфекции. Ру- ководство для врачей. М., «БИНОМ-Пресс». 2003, 289 с.
- Сергеев Ю.В., Шпигель Б.И., Сергеев А.Ю. Фармакоте- рапия микозов. М., «Медицина для всех». 2003, 200 с.
- Carrillo-Muñoz A.J., Tur-Tur C., Giusiano G. et al. Sert- aconazole: an antifungal agent for the topical treatment of superficial candidiasis. Expert. Rev. Anti. Infect. Ther. 2013, v. 11, р. 347-358.
- Соколова Т.В., Мокроносова М.А., Кливитская Н.А., Глушакова А.М. Экспериментальное обоснование спец- ифической активности сертаконазола на Malassezia spp. при атопическом дерматите. Иммунопатол., аллергол., инфектол. 2009, № 2, с. 98-99.
- Croxtall J.D., Plosker G.L. Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynecology. Drugs. 2009, v. 69, р. 339-359.
- Elewski B.E. Safe and effective treatment of seborrheic der- matitis. Cutis. 2009, v. 83, р. 333-338.
- Gil-Lamaignere C., Muller F.M. Differential effects of the combination of caspofungin and terbinafine against Candida albicans, Candida dubliniensis and Candida kefyr. Int. J. An- timicrob. Agents. 2004, v. 23, р. 520-523.
- Leber R., Fuchsbischler S., Klobučnikova V. et al. Molecular Mechanism of Terbinafine Resistance in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 2003, v. 47, р. 3890-3900.
- Liu W. Extra Copies of Aspergillus fumigatus Squalene Epoxi- dase Gen Resistance to Antifungals in A. fumigatus. Antimicrob Agents Chemother. 2004, v. 48, р. 2490-2496.
- Pfaller M.A., Messer S.A., Boyken L. et al. Cross-resistance be- tween fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict susceptibility and resistance to ravuconazole among 12796 clinical isolates of Candida spp. J. Clin. Microbiol. 2004, v. 42, р. 3137-3141.
- Ribotsky B.M. Sertaconazole nitrate cream 2% for the treat- ment of tinea pedis. Cutis. 2009, v.83, р. 274-277.
- Sojakova M., Liptajova D., Borovsky M., Subik J. Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia. Mycopathologia. 2004, v. 157, р. 163-169.
- Sur R.,Babad J.M., Garay M., Liebel F.T., Southall M.D. Anti- inflammatory activity of sertaconazole nitrate is mediated via activation of a p38- COX- 2 - PGE 2 pathway. J. Invest. Dermatol. 2008, v. 128, р. 336-344.
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