Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press49410.36691/RJA494ArticlesСтатьиReview ArticlePLATELET-ACTIVATING FACTOR AND IT’S INTERRELATION WITH ALLERGIC DISEASESТРОМБОЦИТ-АКТИВИРУЮЩИЙ ФАКТОР И ЕГО ВЗАИМОСВЯЗЬ С РЯДОМ АЛЛЕРГИЧЕСКИХ ЗАБОЛЕВАНИЙFOMINAD SФОМИНАД Сdaria.s.fomina@gmail.comGORYACHKINAL AГОРЯЧКИНАЛ АBOBRIKOVAE NБОБРИКОВАЕ НRussian Medical Academy of Postgraduate EducationРоссийская медицинская академия последипломного образования15062014113NO3 (2014)№3 (2014)222810032020Copyright ©; 2014, Pharmarus Print MediaCopyright ©; 2014, Фармарус Принт Медиа2014Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/494

The role of the рlatelet activating factor in allergic diseases remains to be uncertain up to the present. the appearing of the new antihistamine compound with anti-Pat potency directs researcher’s attention to this mediator and it’s role in allergic diseases.

По данным современной литературы, роль фактора, активирующего тромбоциты (ФАТ), при различных заболеваниях, в патогенезе которых участвует аллергический каскад, является неоднозначной и диску- табельной. Появление нового антигистаминного препарата с дополнительным анти-ФАТ потенциалом привело к повышению интереса многих исследователей к данному медиатору и возможных дополни- тельных клинических эффектов от создания рационального алгоритма его назначения.

bronchial asthmaurticariaanaphylaxisтромбоцит-активирующий факторбронхиальная астмакрапивницаанафилаксиярlatelet-activating factorMullol J. Rupatadine in Allergic Rhinitis and Chronic Urti- caria. Allergy. 2008, v. 63, р. 5-28.Quraishi S.A., Davies M.J., Craig T.J. Inflammatory responses in allergic rhinitis: traditional approaches and novel treatment strategies. J. Am. Osteopathol. Assoc. 2004, v. 104, р. 7-15.Pearlman D.S. Pathophysiology of the inflammatory response. J. Allergy Clin. Immunol. 1999, v. 104, р. 132-137.Bascom R., Pipkorn U., Proud D. et al. Major basic pro- tein and eosinophils-derived neurotoxin concentrations in nasal-lavage fluid after antigen challenge: effect of systemic corticosteroids and relationship to eosinophil influx. J. Allergy Clin. Immunol. 1989, v. 84, р. 338-346.Bascom R., Pipkorn U., Lichtenstein L.M., Naclerio R.M. The influx of inflammatory cells into nasal washings during the late- phase response to antigen challenge. Effect of systemic steroid pretreatment. Am. Rev. Respir. Dis. 1988, v. 138, р. 406-412.Гущин И.С., Курбачева О.М. Аллегия и аллергенспеци- фическая иммунотерапия. М., «Фармарус Принт Медиа». 2010, с. 7.Braquet P., Paubert-Braquet, M., Bourgain, R.H. et al. PAF/ cytokine autogenerated feedback networks in microvascular immune injury: consequences in shock, ischemia and graft rejection. J. Lipid. Mediators. 1989, v. 1, р. 75-112.Prescott S.M., Zimmerman G.A., Stafforini D.M. Plate- let-activating factor and related lipid mediators TM. Ann. Rev. Biochem. 2000, v. 69, р. 419-445.Shimizu T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Ann. Rev. Pharmacol. Toxicol. 2009, v. 49, р. 123-150.Church М., Máspero J., Maurer М., Ryan D. The scope of pharmacological and clinical effects of modern antihistamines, with a special focus on Rupatadine. J. WAO. 2010, v. 3, р. 1-16.Shirasaki H., Seki N., Kikuchi M. et al. Expression and localization of platelet-activating factor receptor in human nasal mucosa. Ann. Allergy Asthma Immunol. 2005, v. 95, р. 190-196.Brozek J.L., Bousquet J. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Revision J. Allergy Clin. Immunol. 2010, v. 126, р. 466-476.Stafforini D., Toshio Numao, Tsodikov A. et al. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. J. Clin. Invest. 1999, v. 103, р. 989-997.Kurosawa M., Yamashita T., Kurimoto F. Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms. Allergy. 1994, v. 49, р. 60-63.Kruse S., Mao X.Q., Heinzmann A. et al. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. Am. J. Hum. Genet. 2000, v. 66, р. 1522-1530.Evans D.J., Barnes P.J., Cluzel M., O’Connor B.J. Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. American journal of respiratory and critical care medicine. 1997, v. 156, p. 11-16.Tamura G., Takishima T., Mue S. et al. Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. Adv. Exp. Med. Biol. 1996, v. 416, р. 371-380.Hozawa S., Haruta Y., Ishioka S., Yamakido M. Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma. Am. J. Respir. Crit. Care Med. 1995, v. 152, р. 198-202.Hashimoto E.H. Current treatment of severe asthma Clinical & Experimental. Allergy. 2012, v. 42, p. 693-705.Кузнецова Т.И. Влияние альдегидогенных и ацильных структурных аналогов фактора активации тромбоцитов на образование супероксидных радикалов лейкоцитами крови человека. Биохимия. 1992, т. 57, № 1, с. 16-20.Peter M. Henson. Platelet-activating factor (PAF) as a media- tor of neutrophil-platelet interactions in inflammation. Agents and Actions. 1981, v. 11, p. 545-547.Fauler J., Sielhorst G., Frölich J.C. Platelet-activating factor induces the production of leukotrienes by human monocytes. Biochim. Biophys. Acta. 1989, v. 1013, р. 80-85.Dahl M.L. Aggregating and prostanoid-releasing effects of platelet-activating factor and leukotrienes on human poly- morphonuclear leukocytes and platelets. Int. Arch. Allergy Appl. Immunol. 1985, v. 76, р. 145-150.Izquierdo I., Nieto C., Ramis J. et al. Pharmacokinetics and dose linearity of rupatadine fumarate in healthy volunteers. Exp. Clin. Pharmacol. 1997, v. 19, p. 189.Muñoz-Cano R., Valero A., Izquierdo I. et al. Evaluation of nasal symptoms induced by platelet activating factor, after nasal challenge in both healthy and allergic rhinitis subjects pretreated with rupatadine, levocetirizine or placebo in a cross-over study design. Allergy Asthma Clin. Immunol. 2013, v. 9, р. 43.Macconi D., Foppolo M., Paris S. et al. PAF mediates neu- trophil adhesion to thrombin or TNF-stimulated endothelial cells under shear stress. Am. J. Physiol. 1995, v. 269, р. 42-47.Miyaura S., Eguchi H., Johnston J.M. Effect of a cigarette smoke extract on the metabolism of the proinflammatory autacoid, platelet-activating factor. Circ. Res. 1992, v. 70, р. 341-347.Kajiwara N., Sasaki T., Bradding P. et al. Activation of human mast cells through the platelet-activating factor receptor. J. Allergy Clin. Immunol. 2010, v. 125, р. 1137-1145.Maurer M., Mager M., Metz M. et al. Revisions to theinterna- tional guidelines on the diagnosis and therapy of chronic urti- caria. Journal der Deutschen Dermatologischen Gesellschaft. 2013, v. 11, p. 971-978.Katayama I., Matsui S., Murota H. Platelet activation as a possible indicator of disease activity in chronic urticaria: link with blood coagulation and mast cell degranulatioт. J. Clin. Exp. Dermatol. Res. 2013, v. 4, р. 194-198.Krause K., Giménez-Arnau A., Martinez-Escala E. et al. Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. Allergy. 2013, v. 68, р. 256-258.Grandel K.E., Farr R.S., Wanderer A.A. et al. Association of platelet-activating factor with primary acquired cold urticaria. N. Engl. J. Med. 1985, v. 313, р. 405-409.Takahagi S., Mihara S., Iwamoto K. et al. Coagulation/fibri- nolysis and inflammation markers are associated with disease activity in patients with chronic urticaria. Allergy. 2010, v. 65, р. 649-656.Vadas P., Gold M., Perelman B. et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N. Engl. J. Med. 2008, v. 358, р. 28-35.Vadas P., Perelman B., Liss G.J. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. Allergy Clin. Immunol. 2013, v. 131, р. 144-149.Гущин И.С. Полифункциональная противоаллергическая активность антигистаминного препарата рупатадина. Рос. Аллергол. Журн. 2012, № 4, с. 12-24.Martin Metz, Marcus Maurer. Rupatadine for the treatment of allergic rhinitis and urticaria. Expert Review of Clinical Immunology. 2011, v. 7, р. 15-20.Siebenhaar F., Fortsch A., Krause K. Rupatadine improves quality of life in mastocytosis: a randomized, double-blind, placebo-controlled trial. Allergy. 2013, v. 68, р. 949-952.