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Vol 12, No 6 (2015)

Articles
Editorial
Khaitov P.M., Il'ina N.I.
Russian Journal of Allergy. 2015;12(6):3-4
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Influence of obesity on the natural course of asthma. There are more questions than answers
Glushkova E.F., Shartanova N.V.
Abstract
Recent data about the influence of obesity on bronchial asthma natural course are represented in this article. There are different controversial data about interaction between these two multifactorial diseases. This problem is interested in many researchers working in the fields of endocrinology, therapy, pulmonology, allerglogy, genetics. Nevertheless this interest doesn’t give any clues to many questions coming from scientists.
Russian Journal of Allergy. 2015;12(6):5-12
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Eosinophilic esophagitis. Literature review
Vorzheva I.I., Chernyak B.A.
Abstract
This review summarizes recent research on epidemiology, etiology, mechanisms of development, clinical manifestations, diagnostic criteria and treatment of eosinophilic esophagitis - a disease described about 20 years ago, the prevalence of which is increasing in recent years.
Russian Journal of Allergy. 2015;12(6):13-24
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Experimental mouse model of bronchial asthma induced by house dust mite Dermatophagoides pteronyssinus allergenic extract
Babakhin A.A., Laskin A.A., Kamishnikov O.Y., Shershakova N.N., Shilovskiy I.P., Berzhets V.M., Gushchin I.S., Khaitov M.R.
Abstract
The purpose of this study was to develop a mouse model of asthma (MMA) using house dust mite Dermatophagoides pteronyssinus (Der p) extract. Methods. BALB/c mice were i.p. immunized with different doses of Der p lyophilized extract three times in three week interval in the mixture with Al(OH)3. 8 weeks after the final immunization mice were challenged with Der p during five consecutive days by intranasal applications (INA) or aerosol administration (AA). All mice were divided into 5 experimental groups: group 1 was immunized with 50 ^g/mouse of Der p (in protein equivalent) in the mixture with 2 mg/mouse Al(OH)3 and challenged by INA; group 2 was immunized in the same way and challenged by AA; group 3 was immunized with 100 ^g/mouse Der p in the mixture with 2 mg/mouse of Al(OH)3 and challenged by INA; group was immunized in the same way and challenged by AA; group 5 (negative control) was immunized and challenged with saline. 24 hours after the last challenge airway hyperresponsiveness (AHR) to different concentrations of metha-choline was evaluated in all groups by whole-body plethysmography. 48 hours after the last challenge in all groups blood was collected for differential cell count, brochoalveolar lavage fluid (BALF) was sampled for the determination of inflammatory cells and lungs were removed for histological analysis. Histopathological changes in lungs (allergic inflammation) were graded according to semi-quantitative scoring system. Anti-Der p IgE, IgG1 and IgG2a antibodies in individual sera samples were detected by ELISA seven days after the last immunization and 48 hours after the challenge. Results. The levels of anti-Der p IgE antibodies in groups 1-4 before as well as after the challenge were substantially higher than that of in the group 5 (negative control). The highest level of serum Der p-specific IgE antibodies was observed in the group 2. The levels of anti-Der p IgG1 and IgG2a antibodies in the groups 1-4 during all periods of observation were higher than that of group 5 (negative control). At the same time the maximal levels of anti-Der p IgG1 and IgG2a antibodies were observed in group 3 both after immunization and after challenge. The maximum of AHR was observed in the groups 1 and 3 challenged by INA. Analysis of cell composition in BALF demonstrated significant elevated number of eosinophils in group 3 in comparison with group 5 (negative control) and other experimental groups. Regarding peripheral blood leukocyte count we observed decreasing of band neutrophils in group 4 and increasing of segmented neutrophils in groups 1 and 3 in compare to group 5 (negative control). In group 1 we found statistically significant decreasing of lymphocytes and increasing of eosinophils in compare to negative control group 5. Histological picture of general allergic inflammation in lungs as well as peribronchial and perivascular infiltration with inflammatory cells were the most noticeable (according to score system) in group 3 in comparison with negative control group and other experimental groups. Conclusion. Data obtained indicate that immunization (sensitization) of mice with Der p in a dose 100 μg/mouse together with Al(OH)3 and challenge with Der p by mean of intranasal applications is a suitable approach for modeling of mouse allergic asthma.
Russian Journal of Allergy. 2015;12(6):25-33
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The clinical significance of IgE-antibodies to Malassezia in children with atopic dermatitis
Mokronosova M.A., Turlapova E.V., Glushakova A.M., Pampura A.N., Zheltikova T.M.
Abstract
Background. The objective was to study the species diversity and the proportion of lipophilic yeasts of the genus Malassezia on the skin of children with atopic dermatitis and control groups, to evaluate age-related features and clinical significance of sensitization to Malassezia and IgE-antibodies to Mn-SOD in children with atopic dermatitis. Materials and methods. The study involved 144 children aged between 1 -14 years: 93 patients with atopic dermatitis, a control group of K1 - 24 children with asthma and /or AR without atopic dermatitis and K2 - 27 healthy children without skin diseases. The yeast Malassezia spp. identified by morphological and physiological characteristics and analysis of the nucleotide sequences of the D1/D2 region of 26S (LSU) rDNA. For detection of IgE antibodies to various allergens, including Malassezia, used the device and reagents ImmunoCap (Thermofisher, Sweden); IgE-antibodies to Mn-SOD was detected by the method of ISAC ImmunoCap (Thermofisher, Sweden). Results. Identified 5 species of Malassezia, absolutely dominated M. sympodialis. IgE-antibodies to Malassezia spp. were detected in 45% (42/93) of patients with atopic dermatitis: 11% - children with ADL, 22% from the ADB and 67% from the ADT. Statistically significant correlation between the level of IgE-antibodies to the yeast Malassezia spp. and severity of atopic dermatitis (SCORAD) - r=0,5928, p<0,05 was revealed. The frequency of detection and concentration of IgE-antibodies to Malassezia spp. is increasing with the age of the children. Positive values of IgE-antibodies to Malassezia spp. were identified only in children with presentability. In 7 out of 24 children (29%) with positive IgE values-aT to Malassezia spp. were identified IgE-antibodies to the major fungal allergen - superoxide dismutase Mn (Mn-SOD). Conclusion. Thus, neither species diversity nor the number of yeasts of the genus Malassezia spp. do not affect the severity of atopic dermatitis. The clinical significance of IgE-antibodies to Malassezia spp. and IgE-antibodies to Mn-SOD was shown.
Russian Journal of Allergy. 2015;12(6):34-38
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Infectious and noninfectious sensibilization of patients with bronchial asthma and chronic obstructive pulmonary disease
Fedoseev G.B., Trofimov V.I., Timchik V.G., Negrutsa K.V., Golubeva V.I., Gorovneva E.V., Razumovskaya T.S., Birula I.V., Alexandrin V.A., Kryakunov K.N.
Abstract
The study included 169 patients, particulary 33 healthy people, 69 patients with asthma, 24 patients with asthma combined with chronic obstructive pulmonary disease, 35 patients with chronic obstructive pulmonary disease and 8 patients with community-acquired pneumonia. IgE was determined to mite allergens, house dust, combined pollen meadow grasses, trees and weeds. IgE and IgG were determined to allergens of Strept. pneumonia, Haemofil. influenzae, Neisseria perflava, Staph. aureus. Presence, multiplicity, severity and combination of sensibilization were detected by the presence of specific IgE to infectious and atopic allergens. We revealed sensibilization of all studied groups, including healthy people and patients with chronic obstructive pulmonary disease and community-acquired pneumonia without clinical signs of allergies. There is a statistically significant direct correlation between IgE and IgG reaction to Strept. рneumonia and Haemofil. influenzae of healthy people and patients. There is no correlation between the IgE and IgG reaction of healthy people and patients to Neisseria perflava and Staph. aureus.
Russian Journal of Allergy. 2015;12(6):39-53
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Atopic asthma: the role of allergen-specific immunotherapy
Nenasheva N.M.
Abstract
Bronchial asthma is a heterogeneous disease in terms of the phenotypes, but the majority of patients, both children and adolescents, and adults suffer from IgE-dependent (atopic) asthma. This asthma phenotype most often is associated with allergic rhinitis, which defines systemic therapy for both diseases. The allergen-specific immunotherapy (SIT) meets that approach best of all. SIT is viewed as a treatment not for a specific nosology (rhinitis, asthma or atopic dermatitis), but for an allergen. The epidemiology and the etiology of atopic asthma, role of SIT in treatment of asthma, efficacy, safety, and basic mechanisms are discussed in the article.
Russian Journal of Allergy. 2015;12(6):54-67
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Correction of Stevens-Jonson syndrome - an adverse event of antibiotic therapy
Fatenkov O.V., Kuzmina T.M., Rubanenko O.A., Lobankova O.I., Arsenjeva E.A.
Abstract
Stevens-Johnson syndrome refers to the type B of adverse reactions to drugs according to WHO classification and is severe systemic allergic reaction of delayed type. This syndrome is a severe variant of multiform erythema in which both skin and mucous membranes symptoms are observed. In the article literature data on etiology, pathogenesis and treatment of Stevens-Johnson syndrome as well as clinical case of 24 years old woman with this syndrome are represented.
Russian Journal of Allergy. 2015;12(6):68-71
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Intranasal steroids in treatment of allergic rhinitis
Kurbacheva O.M., Shwets S.M.
Abstract
Allergic rhinitis (AR) is one of the most common diseases affecting adults and children. AR is often a part of a systemic inflammatory process associated with other inflammatory conditions, including allergic conjunctivitis (Ac), rhinosinusitis and asthma. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in asthma development. There is a strong recommendation that clinicians recommend intranasal steroids (INS) for patients with a clinical diagnosis of AR whose symptoms affect their quality of life. All modern INS are minimally bioavailable and similar with regard to efficacy and safety at the recommended starting dose. however, differences in patient preference and safety of use during pregnancy may contribute to primary care physicians’ selection of an INS therapy for their patients.
Russian Journal of Allergy. 2015;12(6):72-79
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Experience of combined topical therapy with methylprednisoloni aceponatis and «Bepanten Plus»® in treatment of adult patients with moderate and severe atopic dermatitis
Shtyrbul O.K., Erina O.A., Fedenko E.S.
Abstract
Background. To estimate efficiency of combined therapy with methylprednisolone aceponatis and «Bepanten Plus»® in adult patients with moderate and severe atopic dermatitis. Methods. We examined 32 adult patients, who were treated with TGCS methylprednisolone aceponatis and «Bepanten Plus»®. The efficiency of therapy was estimated with index SCORAD, IGA and subjective patients assessment. For 15 of 32 patients swabs for bacterial isolation to estimate Staphylococcus aureus growth were taken from lesional skin before therapy and on the 14 th or 20 th days of treatment. Results. The аverage value of index SCORAD decreased after 15 days of therapy, Me 41,7 to Me 23,3 a point (p<0,01), Investigated Global Assessment mediana decreased from 2 to 1 (p<0,01). The colonization density of S. aureus more than 10 3 CFU/cm 2 in all 15 patients before treatment and only in 3 patients in 14-20 days after the treatment was found. Conclusion. Clinical efficiency of «Bepanten Plus»® in combined therapy with methylprednisolone atseponat and its antiseptic action at AD patients has shown.
Russian Journal of Allergy. 2015;12(6):80-83
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The control of skin allergic inflammation in atopic dermatitis with topical calcineurin inhibitors
Elisyutina O.G., Erina O.A.
Abstract
Modern approaches to topical treatment of atopic dermatitis patients with calcineurin inhibitor - pimecrolimus are presented in the review.
Russian Journal of Allergy. 2015;12(6):84-93
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Congresses, Conferences
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Russian Journal of Allergy. 2015;12(6):94-102
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